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New sleep study findings fueled by CCTSI

Patient with Nurse
A recently published study in the journal Current Biology, finds that insufficient sleep reduces the body’s sensitivity to insulin, impairing the ability to regulate blood sugar and increasing the risk of diabetes, according to CCTSI-affiliated researchers at the University of Colorado Anschutz Medical Campus and the University of Colorado Boulder.

The new study adds to a growing body of information linking a lack of sleep to a range of ailments including obesity, metabolic syndrome, mood disorders, cognitive impairment and accidents.

​The Colorado Clinical and Translational Sciences Institute collaborated with the co-leaders of the study, Kenneth Wright, PhD, professor of integrative physiology at CU-Boulder and professor of medicine at the University of Colorado School of Medicine along with Robert Eckel, MD, endocrinologist and professor of medicine at CU Anschutz.

"CCTSI’s laboratory, physician and nursing staff, nutritionists, technicians and the Clinical and Translational Research Center were essential to the success of this study," said Wright. "CU as an institution is incredibly lucky to have the CCTSI and all of its affiliated resources and expertise."​

The CCTSI was created in 2008 to transform the clinical and translational research and training efforts across the state. The CCTSI includes the University of Colorado Denver, the University of Colorado Boulder, Colorado State University, six major hospitals, health care organizations and local communities.

Wright and Eckel looked at 16 healthy men and women in their study. Half of the test subjects initially slept for up to five hours a night for five days to simulate a regular work week.

Then they slept for up to nine hours a night for five days. The other half completed the sleep conditions in the opposite order.

"We found that when people get too little sleep it leaves them awake at a time when their body clock is telling them they should be asleep,” said Wright, the study’s lead author. “And when they eat something in the morning, it impairs their ability to regulate their blood sugar levels."

Blood tests later showed that those who slept five hours a night had a reduced sensitivity to insulin, which in time could increase the risk of getting diabetes.

But when they slept nine hours a night, oral insulin sensitivity returned to normal. Still, it wasn’t enough time to restore intravenous insulin sensitivity to baseline levels.

"We did a study last year showing weight gain is caused by a lack of sleep and now we find that there could also be a risk of diabetes," said Eckel, an expert in diabetes, cardiology and atherosclerosis. "While the exact mechanisms are unknown, it’s clear that a lack of sleep causes metabolic stress."

Wright, director of the Sleep and Chronobiology Laboratory, believes the answer could lay in our body clock.

"We have a clock in our brain which controls 24-hour patterns in our physiology and behavior. It also controls the release of the hormone melatonin which signals our body that it’s night time," Wright said. "High melatonin levels at night tell us to sleep."

But if a person eats instead of sleeps during this time, it may alter the way the body responds to the food, impairing insulin sensitivity, he said.

"The body has to release more insulin to keep blood sugar levels normal," Wright said. "Our bodies can adapt initially but over the long term they may not be able to sustain it."

Diabetes rates are skyrocketing nationwide, said Eckel. By 2050, he noted, as many as 33 percent of all Americans may have Type 2 diabetes.

"In this study we are dealing with healthy individuals," Eckel said. "I think the next step is to test those at a higher risk of diabetes."

Both researchers said the study involved a unique level of collaboration.

"Bob is a diabetes expert and I’m a sleep expert and we brought our expertise together here," Wright said. "This is a great example of collaborative science."

The study was funded by the National Institutes of Health and the Howard Hughes Medical Institute with the Biological Sciences 

Initiative/Undergraduate Research Opportunities Program at CU-Boulder. CCTSI is supported in part by Colorado CTSA Grant UL1TR001082 from the National Center for Advancing Translational Sciences/National Institutes of Health.

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