Dr. Manisha Patel is a Professor in the Department of Pharmaceutical Sciences at the University of Colorado Anschutz Medical Campus. The primary theme of her laboratory’s research is to understand the redox and metabolic basis of neuronal disorders such as epilepsy and develop metabolism-based therapeutic strategies for their treatment. Her early research demonstrated a role for superoxide radicals in excitotoxic cell death and its amelioration by a metalloporphyrin antioxidant. She is actively engaged in preclinical development of neuroprotective therapeutic entities that target reactive oxygen species. She has authored more than 100 scientific publications including articles in the journals Neuron, Journal of Neuroscience, Journal of Biological Chemistry and Proceedings in the National Academy of Sciences. She has been the recipient of numerous grants from the National Institutes of Health, CURE, Michael J. Fox Foundation and the Epilepsy Foundation of America and serves on the editorial boards for FRBM, Redox Biology and Epilepsia Open. She has received the CURE Innovator Award, Shell Prize for Research and Graduate Education and American Epilepsy Society’s Distinguished Service Award. She is a member of the American Epilepsy Society’s board of directors and has chaired its Research and Training Council, Basic Science Committee and Scientific Program Committee. She is the co-chair of the Oxygen Radicals Gordon Research Conference (2020) and serves on scientific advisory boards for CURE and the Epilepsy Foundation’s Innovation Institute (Ei2).
Laboratory training environment: The Patel laboratory has received 20 years of continuous NIH funding as well as funding from research organizations. Dr. Patel is a member of the MSTP, Toxicology and Neuroscience Graduate Training Programs. She served as Chair of the Graduate Training Committee for the UCD Neuroscience Training Program. She has ~18 years of experience in training postdoctoral fellows and graduate students including three underrepresented minorities (URMs). Trainees in the laboratory receive rigorous and comprehensive training in neurochemistry, metabolism, mitochondrial biology, neuroprotection, whole animal and cell culture studies, analytical methods including HPLC-UV/EC, enzymology, free radical methods, drug discovery, statistical analysis and manuscript/grant-writing/presentations. Dr. Patel is committed to training graduate students and postdoctoral researchers in basic and translational neuroscience.
Journal of Neuroscience
Vol. 32, Issue 33
15 Aug 2012
Cover legend: The hydrophilic domain of rat mitochondrial electron transport chain complex I is involved in the production of cellular ATP. During epileptogenesis, arginine 76 (orange spheres) of the 75 kDa subunit (purple ribbon) is irreversibly modified by carbonylation, leading to decreased complex I activity. This residue is located at the interaction interface between the 75 kDa subunit and the 51 kDa subunit (green ribbons), proximal to the NADH binding site (red sticks) and the sulfur-iron center involved in the initial transfer of electrons into the chain (yellow and purple sticks). For more information, see the article by Ryan et al. (pages 11250–11258).