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University of Colorado Denver

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Translational Bio-Nanosciences Laboratory



  1. Ortac I, Simberg D, Yeh Y-S, Yang J, Messmer B, Trogler WC, Tsien RY, Esener S. Dual-Porosity Hollow Nanoparticles for the Immunoprotection and Delivery of Nonhuman Enzymes. Accepted in NanoLetters.


  1. Mukthavaram R, Jiang P, Saklecha R, Bharati I, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Majeti B, Simberg D, Makale M, Kesari S. (2013). Liposomal encapsulation of staurosporine reduces in vivo toxicity and enhances tumor response. Intl Journal of Nanomedicine (In press).
  2. Shi, G.; Cui, W.; Mukthavaram, R.; Liu, Y. T.; Simberg, D., Binding and Isolation of Tumor Cells in Biological Media with Perfluorocarbon Microbubbles. Methods 2013. In press.
  3. Shi G, Mukthavaram R, Kesari S, Simberg D. Distearoyl anchor-painted erythrocytes with prolonged ligand retention and circulation properties in vivo. Adv. Healthcare Mater, 2013.
  4. Chao Y, Karmali P, Mukthavaram R, Kesari S, Kouznetsova V, Tsigelny I, Simberg D. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano, 2013, 7, 4289-4298.
  5. Shi, G., Cui, W., Benchimol, M., Liu, Y.-T., Mattrey, R., Kesari, S., Esener, S.C., and Simberg, D. (2013). Isolation of rare tumor cells from blood cells with buoyant perfluorocarbon immuno-microbubbles. PLoS One, 2013, 8, e58017.


  1. Chao Y, Makale M, Karmali P, Tsigelny I, Merkulov S, Ruoslahti E, Simberg D. Recognition of dextran-coated superparamagnetic iron oxide nanoparticles (Feridex) by charged domains of macrophage scavenger receptors. Bioconjugate Chemistry, 2012, 23 (5), 1003–1009.
  2. Karmali P, Chao Y, Park J-H, Sailor M, Ruoslahti E, Esener S, Simberg D. Different effect of hydrogelation on anti-fouling and circulation properties of iron oxide nanoparticles. Mol Pharmaceutics, 2012, 9 (3), pp 539–545.
  3. Karmali P, Chao Y, Merkulov S, Ruoslahti E, Simberg D. Role of carbohydrate (lectin) receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles. Adv Exp Med Biol. 2012;733:115-23.
  4. Ibsen S, Benchimol M, Simberg D, Esener S. Ultrasound mediated localized drug delivery. Adv Exp Med Biol. 2012;733:145-53.


  1. Ibsen S, Benchimol M, Simberg D, Steiner J, Esener S. A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. J. Control Release 2011: 155(3):358-66.
  2. Simberg D and Tsigelny I. Has the time for in silico design of nanomedicines finally arrived? Editorial in J Nanomedic Biotherapeu Discover 2011; 1:104e. doi:10.4172/2155-983X.1000104e.
  3. Karmali, PP. and Simberg D. Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems. Expert Opinion Drug Delivery 2011 8(3): 343-357. Invited review.