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University of Colorado Denver


Translational Bio-Nanosciences Laboratory




1.    Wang G…. Simberg D. Rapid Harvesting of Highly Concentrated Tumor Cells from Bulk Human Blood with Buoyant Immuno-microbubbles

2.    Chen F…. Simberg D. Dynamic assembly of complement factors on the protein corona of core-shell nanoparticles


1.    Wang, G.; Simberg, D., Role of Scavenger Receptors in Immune Recognition and Targeting of Nanoparticles. Reviews in Cell Biology and Molecular Medicine 2015, 1, 166-189.

2.    Simberg, D., Opening Windows into Tumors. ACS Nano 2015, 9, 8647-8650.

3.    Inturi, S.; Wang, G.; Chen, F.; Banda, N. K.; Holers, V. M.; Wu, L.; Moghimi, S. M.; Simberg, D., Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. ACS Nano 2015, 9, 10758-10768., Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. ACS Nano 2015, 9, 10758-10768.


  1. Ibsen, S.; Shi, G.; Schutt, C.; Shi, L.; Suico, K. D.; Benchimol, M.; Serra, V.; Simberg, D.; Berns, M.; Esener, S., The Behavior of Lipid Debris Left on Cell Surfaces from Microbubble Based Ultrasound Molecular Imaging. Ultrasonics 2014, 54, 2090-8.
  2. Wang, G.; Inturi, S.; Serkova, N. J.; Merkulov, S.; McCrae, K.; Russek, S. E.; Banda, N. K.; Simberg, D., High-Relaxivity Superparamagnetic Iron Oxide Nanoworms with Decreased Immune Recognition and Long-Circulating Properties. ACS Nano 2014.
  3. Banda, N. K.; Mehta, G.; Chao, Y.; Wang, G.; Inturi, S.; Fossati-Jimack, L.; Botto, M.; Wu, L.; Moghimi, S.; Simberg, D., Mechanisms of Complement Activation by Dextran-Coated Superparamagnetic Iron Oxide (Spio) Nanoworms in Mouse Versus Human Serum. Particle and fibre toxicology 2014, 11, 64.
  4. Ortac, I.; Simberg, D.; Yeh, Y. S.; Yang, J.; Messmer, B.; Trogler, W. C.; Tsien, R. Y.; Esener, S., Dual-Porosity Hollow Nanoparticles for the Immunoprotection and Delivery of Nonhuman Enzymes. Nano letters 2014, 14, 3023-32.
  5. Mukthavaram, R.; Shi, G.; Kesari, S.; Simberg, D., Targeting and Depletion of Circulating Leukocytes and Cancer Cells by Lipophilic Antibody-Modified Erythrocytes. Journal of controlled release 2014, 183, 146-53.
  6. Simberg, D.; Tsigelny, I., On the Importance of Understanding Biointeractions of Nanomaterials with the Immune System. International Journal of Nano Studies & Technology 2014, Editorial.
  7. Shi, G.; Mukthavaram, R.; Kesari, S.; Simberg, D., Distearoyl Anchor-Painted Erythrocytes with Prolonged Ligand Retention and Circulation Properties in Vivo. Advanced healthcare materials 2014, 3, 142-8.
  8. Moghimi, S. M.; Trippler, K. C.; Simberg, D., The Art of Complement: Complement Sensing of Nanoparticles and Consequences. In Nanomedicine : Nanotechnology, Biology, and Medicine, Vorup-Jensen, T.; Howard, K.; Peer, D., Eds. Springer: 2014.


  1. Mukthavaram, R.; Jiang, P.; Saklecha, R.; Simberg, D.; Bharati, I. S.; Nomura, N.; Chao, Y.; Pastorino, S.; Pingle, S. C.; Fogal, V.; Wrasidlo, W.; Makale, M.; Kesari, S., High-Efficiency Liposomal Encapsulation of a Tyrosine Kinase Inhibitor Leads to Improved in Vivo Toxicity and Tumor Response Profile. International journal of nanomedicine 2013, 8, 3991-4006.
  2. Shi, G.; Cui, W.; Mukthavaram, R.; Liu, Y. T.; Simberg, D., Binding and Isolation of Tumor Cells in Biological Media with Perfluorocarbon Microbubbles. Methods 2013, 64, 102-7.
  3. Chao Y, Karmali P, Mukthavaram R, Kesari S, Kouznetsova V, Tsigelny I, Simberg D. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano, 2013, 7, 4289-4298.
  4. Shi, G., Cui, W., Benchimol, M., Liu, Y.-T., Mattrey, R., Kesari, S., Esener, S.C., and Simberg, D. (2013). Isolation of rare tumor cells from blood cells with buoyant perfluorocarbon immuno-microbubbles. PLoS One, 2013, 8, e58017.


  1. Chao Y, Makale M, Karmali P, Tsigelny I, Merkulov S, Ruoslahti E, Simberg D. Recognition of dextran-coated superparamagnetic iron oxide nanoparticles (Feridex) by charged domains of macrophage scavenger receptors. Bioconjugate Chemistry, 2012, 23 (5), 1003–1009.
  2. Karmali P, Chao Y, Park J-H, Sailor M, Ruoslahti E, Esener S, Simberg D. Different effect of hydrogelation on anti-fouling and circulation properties of iron oxide nanoparticles. Mol Pharmaceutics, 2012, 9 (3), pp 539–545.
  3. Karmali P, Chao Y, Merkulov S, Ruoslahti E, Simberg D. Role of carbohydrate (lectin) receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles. Adv Exp Med Biol. 2012;733:115-23.
  4. Ibsen S, Benchimol M, Simberg D, Esener S. Ultrasound mediated localized drug delivery. Adv Exp Med Biol. 2012;733:145-53.


  1. Ibsen S, Benchimol M, Simberg D, Steiner J, Esener S. A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. J. Control Release 2011: 155(3):358-66.
  2. Simberg D and Tsigelny I. Has the time for in silico design of nanomedicines finally arrived? Editorial in J Nanomedic Biotherapeu Discover 2011; 1:104e. doi:10.4172/2155-983X.1000104e
  3. Karmali, PP. and Simberg D. Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems. Expert Opinion Drug Delivery 2011 8(3): 343-357. Invited review.