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Translational Bio-Nanosciences Laboratory



1.  James I. Griffin, Siu Kit (Kevin) Cheng, Tomoko Hayashi, Dennis Carson, Manju Saraswathy, Devatha P. Nair and Dmitri Simberg. Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. In revision.

2.  SM Moghimi and Dmitri Simberg: Nanoparticle-blood interface dynamics: changeable complement activation through surface absorbed proteins.  Perspective. Nano Today.

3.  Wang, F. Chen, L. Wu, M. Moghimi, D. Simberg. In vitro and in vivo differences in murine third complement component (C3) opsonization and macrophage/leukocyte responses to antibody-functionalized iron oxide nanoworms. Accepted (Frontiers Immunol) 2017.

4.  James I. Griffin, Michael J. Benchimol and Dmitri Simberg. Longitudinal monitoring of accumulation of drug carriers and biologicals in the skin by non-invasive near-infrared fluorescence spectroscopy. J Control Release 2017.

5.  Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D. Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano 2017


1.  Fangfang Chen, Guankui Wang, James I. Griffin, Barbara Brenneman, Nirmal K. Banda, V. Michael Holers, Donald S. Backos, LinPing Wu, Seyed Moein Moghimi and Dmitri Simberg.  Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nature Nanotechnology 2016

2. Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D. Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking. Front Immunol. 2016 Oct 10;7:418

3. Simberg D. Iron oxide nanoparticles and the mechanisms of immune recognition of nanomedicines. Nanomedicine 2016


1.   Inturi, S.; Wang, G.; Chen, F.; Banda, N. K.; Holers, V. M.; Wu, L.; Moghimi, S. M.; Simberg, D., Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms on Complement Opsonization and Leukocyte Uptake. ACS Nano 2015

2.  Simberg D. Opening Windows into tumors. ACS Nano 2015


  1. Ibsen, S.; Shi, G.; Schutt, C.; Shi, L.; Suico, K. D.; Benchimol, M.; Serra, V.; Simberg, D.; Berns, M.; Esener, S., The Behavior of Lipid Debris Left on Cell Surfaces from Microbubble Based Ultrasound Molecular Imaging. Ultrasonics 2014, 54, 2090-8.
  2. Wang, G.; Inturi, S.; Serkova, N. J.; Merkulov, S.; McCrae, K.; Russek, S. E.; Banda, N. K.; Simberg, D., High-Relaxivity Superparamagnetic Iron Oxide Nanoworms with Decreased Immune Recognition and Long-Circulating Properties. ACS Nano 2014.
  3. Banda, N. K.; Mehta, G.; Chao, Y.; Wang, G.; Inturi, S.; Fossati-Jimack, L.; Botto, M.; Wu, L.; Moghimi, S.; Simberg, D., Mechanisms of Complement Activation by Dextran-Coated Superparamagnetic Iron Oxide (Spio) Nanoworms in Mouse Versus Human Serum. Particle and fibre toxicology 2014, 11, 64.
  4. Ortac, I.; Simberg, D.; Yeh, Y. S.; Yang, J.; Messmer, B.; Trogler, W. C.; Tsien, R. Y.; Esener, S., Dual-Porosity Hollow Nanoparticles for the Immunoprotection and Delivery of Nonhuman Enzymes. Nano letters 2014, 14, 3023-32.
  5. Mukthavaram, R.; Shi, G.; Kesari, S.; Simberg, D., Targeting and Depletion of Circulating Leukocytes and Cancer Cells by Lipophilic Antibody-Modified Erythrocytes. Journal of controlled release 2014, 183, 146-53.
  6. Simberg, D.; Tsigelny, I., On the Importance of Understanding Biointeractions of Nanomaterials with the Immune System. International Journal of Nano Studies & Technology 2014, Editorial.
  7. Shi, G.; Mukthavaram, R.; Kesari, S.; Simberg, D., Distearoyl Anchor-Painted Erythrocytes with Prolonged Ligand Retention and Circulation Properties in Vivo. Advanced healthcare materials 2014, 3, 142-8.
  8. Moghimi, S. M.; Trippler, K. C.; Simberg, D., The Art of Complement: Complement Sensing of Nanoparticles and Consequences. In Nanomedicine : Nanotechnology, Biology, and Medicine, Vorup-Jensen, T.; Howard, K.; Peer, D., Eds. Springer: 2014.


  1. Mukthavaram, R.; Jiang, P.; Saklecha, R.; Simberg, D.; Bharati, I. S.; Nomura, N.; Chao, Y.; Pastorino, S.; Pingle, S. C.; Fogal, V.; Wrasidlo, W.; Makale, M.; Kesari, S., High-Efficiency Liposomal Encapsulation of a Tyrosine Kinase Inhibitor Leads to Improved in Vivo Toxicity and Tumor Response Profile. International journal of nanomedicine 2013, 8, 3991-4006.
  2. Shi, G.; Cui, W.; Mukthavaram, R.; Liu, Y. T.; Simberg, D., Binding and Isolation of Tumor Cells in Biological Media with Perfluorocarbon Microbubbles. Methods 2013, 64, 102-7.
  3. Chao Y, Karmali P, Mukthavaram R, Kesari S, Kouznetsova V, Tsigelny I, Simberg D. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano, 2013, 7, 4289-4298.
  4. Shi, G., Cui, W., Benchimol, M., Liu, Y.-T., Mattrey, R., Kesari, S., Esener, S.C., and Simberg, D. (2013). Isolation of rare tumor cells from blood cells with buoyant perfluorocarbon immuno-microbubbles. PLoS One, 2013, 8, e58017.


  1. Chao Y, Makale M, Karmali P, Tsigelny I, Merkulov S, Ruoslahti E, Simberg D. Recognition of dextran-coated superparamagnetic iron oxide nanoparticles (Feridex) by charged domains of macrophage scavenger receptors. Bioconjugate Chemistry, 2012, 23 (5), 1003–1009.
  2. Karmali P, Chao Y, Park J-H, Sailor M, Ruoslahti E, Esener S, Simberg D. Different effect of hydrogelation on anti-fouling and circulation properties of iron oxide nanoparticles. Mol Pharmaceutics, 2012, 9 (3), pp 539–545.
  3. Karmali P, Chao Y, Merkulov S, Ruoslahti E, Simberg D. Role of carbohydrate (lectin) receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles. Adv Exp Med Biol. 2012;733:115-23.
  4. Ibsen S, Benchimol M, Simberg D, Esener S. Ultrasound mediated localized drug delivery. Adv Exp Med Biol. 2012;733:145-53.


  1. Ibsen S, Benchimol M, Simberg D, Steiner J, Esener S. A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. J. Control Release 2011: 155(3):358-66.
  2. Simberg D and Tsigelny I. Has the time for in silico design of nanomedicines finally arrived? Editorial in J Nanomedic Biotherapeu Discover 2011; 1:104e. doi:10.4172/2155-983X.1000104e
  3. Karmali, PP. and Simberg D. Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems. Expert Opinion Drug Delivery 2011 8(3): 343-357. Invited review.