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Systems Genetics and Bioinformatics

Recent Publications


Systems genetics

  • Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 Oct;27(9-10):469-84.
  • Saba LM, Flink SL, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome, its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep;282(18):3556-78.
  • Bennett B, Larson C, Richmond P, Odell A, Saba L, Tabakoff B, Dowell R, Radcliffe R. QTL Mapping of Acute Functional Tolerance in the LXS Recombinant Inbred Strains. Alcohol Clin Exp Res. 2015 Apr;39(4):611-20.
  • Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff B. Influence of sex on genetic regulation of “drinking in the dark” alcohol consumption. Mamm Genome. 2015 Feb;26(1-2):43-56.
  • Hoffman PL, Saba LM, Flink S, Grahame NJ, Kechris K, Tabakoff B. Genetics of gene expression characterizes response to selective breeding for alcohol preference. Genes Brain Behav. 2014 Nov;13(8):743-57.
  • Vanderlinden L, Saba L, Printz, M, Flodman P, Koob G, Richardson H, Hoffman P, Tabakoff B. Is the Alcohol Deprivation Effect Genetically Mediated? Studies with HXB/BXH Recombinant Inbred Rat Strains. Alcohol Clin Exp Res 2014 Jul;38(7):2148-57.
  • Vanderlinden LA, Saba LM, Kechris K, Hoffman PL, Tabakoff B. Gene co-expression networks provide insight into genetic determinants of alcohol consumption. PLoS One 2013 Jul 23;8(7):e68878. *This publication is a result of a student’s thesis work.

Pathway analysis in proteomics analysis of protein modifications

  • Shearn CT, Orlicky DJ, Saba LM, Shearn AH, Petersen DR. Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis. Free Radic Biol Med. 2015 Oct 27. pii: S0891-5849(15)01089-8.
  • Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr;7:68-77.
  • Coughlan C, Walker DI, Lohr K, Lazo CR, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative proteomic analysis of carbonylated proteins from the striatum and cortex of pesticide treated mice. Parkinsons Dis. 2015;2015:812532.

Human gene association studies

  • Zuo L, Saba L, Zhang X-Y, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians. Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):544-56.
  • Zuo L, Saba L, Wang K, Zhang XY, Krystal JH, Tabakoff B, Luo X. Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. J Stud Alcohol Drugs. 2013 Jul;74(4):622-5.
  • Procopio D, Saba L, Walter H, Lesch O, Skala K, Schlaff G, Vanderlinden L, Clapp P, Hoffman P, Tabakoff B. Genetic Markers of Co-Morbid Depression and Alcoholism in Women. Alcohol Clin Exp Res. 2013 Jun;37(6):896-904.

Biomarkers

  • Snell LD, Ramchandani VA, Saba L, Herion D, Heilig M, George DT, Pridzun L, Helander A, Schwandt ML, Phillips MJ, Hoffman PL, Tabakoff B; and the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence Investigators. The Biometric Measurement of Alcohol Consumption. Alcohol Clin Exp Res 2012 Feb;36(2):332-41.

View a full list of publications.

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