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University of Colorado Denver


Nanotoxicology Lab


Abdullah A. Aldossari, Jonathan H. Shannahan, Ramakrishna Podila, Jared M. Brown. Influence of Physicochemical Properties of Silver Nanoparticles on Mast Cell Activation and Degranulation. Toxicology In Vitro, 2014.

Jonathan H. Shannahan, Ramakrishna Podila, Abdullah A. Aldossari, Hilary Emerson, Brian Powell, Pu Chun Ke, Apparao M. Rao, Jared M. Brown.  Formation of a Protein Corona on Silver Nanoparticles Mediates Cellular Toxicity via Scavenger Receptors. Toxicological Sciences, 2014.

Achini K. Vidanapathirana, Leslie C. Thompson, Erin E. Mann, Jillian Odom, Nathan A. Holland, Susan J. Sumner, Li Han, Anita H. Lewin, Timothy R. Fennell, Jared M. Brown, Christopher J. Wingard.  PVP Formulated Fullerene (C60) Increases Rho-Kinase Dependent Vascular Tissue Contractility in Pregnant Sprague Dawley Rats.  Reproductive Toxicology, 2014.    

Slaven Radic, Praveen Nedumpully-Gavindan, Ran Chen, Emppu Salonen, Jared M. Brown, Pu Chun Ke, Feng Ding. The Effect of Fullerenol Surface Chemistry on Nanoparticle Binding-Induced Protein Misfolding. Nanoscale. 2014.

Achini K Vidanapathirana, Leslie C. Thompson, Jilliam Odom, Nathan A. Holland, Susan J. Sumner, Timothy R. Fennell, Jared M. Brown, Christopher J. Wingard. Vascular Tissue Contractility Changes Following Late Gestational Exposure to Multi-Walled Carbon Nanotubes or Their Dispersing Vehicle in Sprague Dawley Rats. Journal of Nanomedicine & Nanotechnology. 2014.

Donald S. Anderson, Esther S. Patchin, Rona M. Silva, Dale L. Uyeminami, Arjun Sharmah, Ting Guo, Gautom K. Das, Jared M. Brown, Jonathan Shannahan, Terry Gordon, Lung Chi Chen, Kent E. Pinkerton, Laura S. Van Winkle. Influence of Particle Size on Persistence and Clearance of Aerosolized Silver Nanoparticles in the Rat Lung. Toxicological Sciences. 2015.

Jonathan H. Shannahan and Jared M. Brown. Engineered Nanomaterial Exposure and the Risk of Allergic Disease. Current Opinion in Allergy and Clinical Immunology. 2014.

Matthew J. Smith, Jared M. Brown, William C. Zamboni, Nigel J. Walker. Symposium Overview: From Immunotoxicity to Nanotherapy: The Effects of Nanomaterials on the Immune System. Toxicological Sciences. 2014.

Xiaojia Wang, Jonathan H. Shannahan, Jared M. Brown. IL-33 Modulates Chronic Airway Resistance Changes Induced by Multi-Walled Carbon Nanotubes. Inhalation Toxicology. 2014

Leslie C. Thompson, Rakhee N. Urankar, Nathan A. Holland, Achini K. Vidanapathirana, Joshua E. Pitzer, Li Han, Susan J. Sumner, Anita H. Lewin, Timothy R. Fennell, Robert M. Lust, Jared M. Brown, Christopher J. Wingard. C60 Exposure Augments Cardiac Ischemia/Reperfusion Injury and Coronary Tone in Sprague-Dawley Rat. Toxicological Sciences. 2014.

Jonathan H. Shannahan, Xianyin Lai, Pu Chun Ke, Ramakrishna Podila, Jared M. Brown, Frank A. Witzmann.  Silver Nanoparticle Protein Corona Composition in Cell Culture Media.  In Press.  PLOS ONE, 2013. 

Feng Ding, Slavin Radic, Poonam Choudhary, Ran Chen, Jared M. Brown, Pu-Chun Ke.  Direct Observation of Silver Nanoparticle-Ubiquitin Corona Formation.  In Press.  Nanoscale, 2013.   

Xiaojia Wang, Ramakrishna Podila, Jonathan H. Shannahan, Jared M. Brown.  Intravenously Delivered Graphene Nanosheets and Multi-Walled Carbon Nanotubes Induce Site Specific Th2 Inflammatory Responses via the IL-33/ST2 Axis.  In Press.  International Journal of Nanomedicine,  2013.

Thomas Moore, Joshua E. Pitzer, Ramakrishna Podila, Xioajia Wang, Robert Lewis, James Wilson, Even Skjervold, Jared M. Brown, Apparao M. Rao, Frank Alexis.  Multifunctional Polymer Coated Carbon Nanotubes for Safe Drug Delivery.  Particle & Particle Systems Characterization,  2013.  30, 365-373. 

Jonathan Shannahan, Jared M. Brown, Ran Chen, Pu-Chun Ke, Xianyin Lai, Somenath Mitra, Frank A. Witzmann.  Comparison of Nanotube-Protein Corona Composition in Cell Culture Media.  Small,  2013. 

Mi-Yeon Jung, Daniel Smrz, Avanti Desai, Geethani Bandara, Tomonobu Ito, Shoko Iwaki, Jeong-Han Kang, Marcus Andrade, Susana C. Hilderbrand, Jared M. Brown, Michael A. Beaven, Dean D. Metcalfe, Alasdair M. Gilfillan.  IL-33 Induces a Hypo-Responsive Phenotype in Human and Mouse Mast Cells.   Journal of Immunology2013.  190(2).  531-538

Ramakrishna Podila, Ran Chen, Pu-Chun Ke, Jared M. Brown, Apparao M. Rao.  Effects of Surface Functional Groups on the Formation of Nanoparticle-Protein Corona.  Applied Physics Letters,  2012.  101(26).

Leslie C. Thompson, Chad R. Frasier, Ruben C. Sloan, Erin E. Mann, Benjamin S. Harrison, Jared M. Brown, David A. Brown, Christopher J. Wingard.  Pulmonary Instillation of Multi-Walled Carbon Nanotubes Promotes Coronary Vasoconstriction and Exacerbates Injury in Isolated Hearts.  Nanotoxicology,  2012.  1-44. 

James C. Bonner, Rona Silva, Alexia Taylor, Jared M. Brown, Susana C. Hilderbrand, Vincent Castranova, Dale Porter, Alison Elder, Gunter Oberdorster, Jack Harkema, Lori Bramble, Terrence Kavanagh, Dianne Botta, Andre Nel, Kent Pinkerton.  Interlaboratory In Vivo Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials.  In Press. Environmental Health Perspectives

Ramakrishna Podila, Pallavi Vedantam, Pu-Chun Ke, Jared M. Brown, Apparao M. Rao.  Evidences for Charge Transfer-Induced Conformational Changes in Carbon Nanostructure-Protein Corona.  Journal of Physical Chemistry C,  2012.  116(41). 22098-22103. 

Rahkee N. Urankar, Robert M. Lust, Erin Mann, Pranita Katwa, Xiaojia Wang, Benjamin S. Harrison, Pengyu Chen, Pu Chun Ke, Apparao M. Rao, Ramakrishna Podila, Jared M. Brown, Christoper J. Wingard.  Expansion of Cardiac Ischemia/Reperfusion Injury in Response to Three Forms of Instilled Multi-Walled Carbon Nanotubes.  Particle and Fibre Toxicology,  2012; 9:38. 

Ran Chen, Slaven Radic, Poonam Choudhary, Kimberley G. Ledwell, Jared M. Brown, Pu-Chun Ke.  Formation and Cell Translocation of Carbon Nanotube-Fibrinogen Protein Corona.  Applied Physics Letters2012. 101(13):133702. 

Achini K. Vidanapathirana, Xianyin Lai, Susana C. Hilderbrand, Josh E. Pitzer, Ramakrishna Podila, Susan J. Sumner, Timothy R. Fennell, Christopher J. Wingard, Frank A. Witzmann, Jared M. Brown.  Multi-Walled Carbon Nanotube Directed Gene and Protein Expression in Cultured Human Aortic Endothelial Cells is Influenced by Suspension Media.  Toxicology,  2012. 302:(2-3) 114-22. 

Priyanka Bhattacharya, Seung-Ha Kim, Pengyu Chen, Anne M. Spuches, Jared M. Brown, Monica H. Lamm, Pu Chun Ke.  Dendrimer-Fullerenol Soft-Condensed Nanoassembly.  Journal of Physical Chemistry C,  2012. 116(29) 15775-15781.

Pranita Katwa, Xiaojia Wang, Rakhee N. Urankar, Ramakrishna Podila, Susana C. Hilderbrand, Robert B. Fick, Apparao M. Rao, Pu-Chun Ke, Chistopher J. Wingard, Jared M. Brown.  A Novel Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL-33/ST2 Axis.  Small,  2012. 8:18.  2904-2912.

Ran Chen, Poonam Choudhary, Ryan N. Schurr, Priyanka Bhattacharya, Jared M. Brown, Pu Chun Ke.  Interaction of Lipid Vesicle with Silver Nanoparticle-HSA Protein Corona.  Applied Physics Letters,  2012. 100.  
Jonathan H. Shannahan, Urmila P. Kodavanti, Jared M. Brown.  Manufactured and Airborne Nanoparticle Cardiopulmonary Interactions: A Review of Mechanisms and the Possible Contribution of Mast Cells.  Inhalation Toxicology, 2012; 24(5): 320-339. 

Jonathan H. Shannahan, Wei Bai, Jared M. Brown. Implications of Scavenger Receptors in the Safe Development of Nanotherapeutics. Receptors and Clinical Investigation. 2015

Ramakrishna Podila and Jared M. Brown.  Toxicity of Engineered Nanomaterials:  A Physicochemical Perspective.  Journal of Biochemical and Molecular Toxicology.  2012. 

Xiaojia Wang, Shaun Reece, Jared M. Brown.  Immunotoxicological Impact of Engineered Nanomaterial Exposure:  Mechanisms of Immune Cell Modulation. Toxicology Mechanisms and Methods.  2012.  1-40. 

Xiaojia Wang, Pranita Katwa, Ramakrishna Podila, Pengyu Chen, Pu Chun Ke, Apparao M. Rao, Dianne M. Walters, Christopher J. Wingard, Jared M. Brown.  Multi-Walled Carbon Nanotube Instillation Impairs Pulmonary Function in C57BL/6 Mice.  Particle and Fibre Toxicology,  2011. 8:24. 

Christopher J. Wingard, Dianne M. Walters, Brook L. Cathey, Susana C. Hilderbrand, Pranita Katwa, Sijie Lin, Pu Chun Ke, Ramakrishna Podila, Apparao Rao, Robert M. Lust, Jared M. Brown.  Mast Cells Contribute to Alteration of Vascular Reactivity and Myocardial Ischemia/Reperfusion Injury Following Instillation of Cerium Oxide Nanoparticles.  Nanotoxicology.  2011. 5(4): 531-545.