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University of Colorado Denver

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Uday B. Kompella Profile

Learn more about Dr. Uday B. Kompella

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Kompella Research Lab

Lab Members


 

Current Lab Member Profiles

Click on the individuals name to learn more about each member’s research projects and roles.

Rinku Baid

Rinku Baid: Graduate Student
Phone: Phone: 303.724.4026
Rinku’s graduate research focuses on the development of novel protein delivery system that can be used for the treatment of retinal degenerative diseases.

Kristen Grompone

Kristen Grompone: Professional Research Assistant
Phone: Phone: 303.724.5288
Kristen’s research focuses on the use of noninvasive monitoring of therapeutics delivered to the eye. She is also responsible for maintaining the administrative aspects of the Kompella lab.

Gajanan Jadhav

Gajanan Jadhav: Visiting Research Associate
Phone: Phone: 303.724.4026
Gajanan’s research focuses on Ocular Drug Disposition.

Rajendra Kadam

Rajendra Kadam: Graduate Student
Phone: Phone: 303.724.4026
Rajendra’s research focuses on Ocular Drug Disposition.

Publications:

  1. Kadam, R.S. and Kompella, U.B.* Influence of lipophilicity on drug partitioning into sclera, choroid-RPE, retina, trabecular meshwork, and optic nerve. J. Pharmacol. Exp. Ther. 2009. PMID: 19926800.
  2. Kim, E.S., Durairaj, C., Kompella, U.B., Kadam, R.S., Lee, S.J., Mo, Y., Geroski, D.H., and Edelhauser, H.F. Human scleral diffusion of anticancer drugs from solution and nanoparticle formulations. Pharm. Res. 26(5):1155-1161 (2009).
  3. Sundaram, S., Durairaj, C., Kadam, R., and Kompella, U.B.* Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy. Mol. Cancer Ther. 8(6):1655-1665 (2009).
  4. Kadam, R. and Kompella, U.B.* Cassette analysis of eight beta-blockers in bovine eye sclera, choroid-RPE, retina and vitreous by liquid chromatography-tandem mass spectrometry. J. Chromat. B 877(3):253-260 (2009).
  5. Kratzer, A., Buchebner, M., Pfeifer, T., Becker, T.M., Uray, G., Miyazaki, M., Miyazaki-Anzai, S., Ebner, B., Chandak, P.G., Kadam, R.S., Calayir, E., Rathke, N., Ahammer, H., Radovic, B., Trauner, M., Hoefler, G., Kompella, U.B., Fauler, G., Levi, M., Levak-Frank, S., Kostner, G.M., Kratky, D. Synthetic LXR agonist attenuates plaque formation in apoE-deficient mice without inducing liver steatosis and hypertriglyceridemia. J Lipid Res. 50(2): 312-326 (2009).

Vidhya Rao

Vidhya Rao: Post Doctoral Fellow.
Phone: 303.724.4026
Vidhya’s research focuses on the development of therapeutics for diabetic retinopathy.

Publications

  1. Rao, V.R., Prescott, E., Shelke, N., Trivedi, R., Thomas, P., Struble, C., Gadek, T., O’Neill, C.A., Kompella, U.B.* Delivery of SAR 1118 to retina via ophthalmic drops and its effectiveness in reduction of retinal leukostasis and vascular leakiness in rat streptozotocin (STZ) model of diabetic retinopathy (DR). Invest. Ophthalmol. Vis. Sci. (submitted).

Sneha Sundaram

Sneha Sundaram: Post Doctoral Fellow
Phone: 303.724.5288
Sneha’s research focuses on the use of Deslorelin functionalized nanosystems for anti-cancer drug and gene delivery.

Publications

  1. Sundaram, S., Durairaj, C., Ambati, B.K., Rajagopal, R., and Kompella, U.B.* Targeted drug and gene delivery systems for lung cancer therapy. Clin. Cancer Res. 15(23):7299-7308 (2009). PMID: 19920099.
  2. Sundaram, S., Roy, S.K., Ambati, B.K., and Kompella, U.B.* Surface functionalized nanoparticles for targeted gene delivery across nasal respiratory epithelium. FASEB J. 23(11):3752-3765 (2009).
  3. Sundaram, S., Durairaj, C., Kadam, R., and Kompella, U.B.* Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy. Mol. Cancer Ther. 8(6):1655-1665 (2009).
  4. Sundaram, S., Roy, S.K., Kompella, U.B.* Differential expression of LHRH-receptor in bovine nasal tissue and its role in deslorelin delivery. Peptides. 30(2):351-358 (2009).
  5. Kompella, U.B.*, Sundaram, S., Raghava, S., and Escobar, E. Functionalizations enhance nanoparticles delivery in a novel bovine ex vivo eye model. Mol. Vis. 12: 1185-1198 (2006).
  6. Sundaram, S., Bontha, S. S., and Kompella, U.B.* Respiratory delivery of deslorelin, a peptide drug. Am. Pharm. Rev. 7(5):130-139 (2004).
  7. Amrite, A.A., Cheruvu, N.P.S., Sundaram, S., Aravalli, R.N., Cheng, P-W, and Kompella, U.B.* Lung Gene Therapy: Clinical and Regulatory Issues. Clin. Res. Reg. Affairs 21:1-28 (2004).

Ashish Thakur

Ashish Thakur: Research Staff
Phone: 303.724.4026
Ashish’s research focuses on the development of prodrugs for posterior ocular disorders.

Ruchit Trivedi

Ruchit Trivedi: Graduate Student
Phone: 303.724.4026
Ruchit’s research focuses on the development of nanosystems for drug delivery to the lungs for the treatment of cancer.

Publications

  1. Rao, V.R., Prescott, E., Shelke, N., Trivedi, R., Thomas, P., Struble, C., Gadek, T., O’Neill, C.A., Kompella, U.B.* Delivery of SAR 1118 to retina via ophthalmic drops and its effectiveness in reduction of retinal leukostasis and vascular leakiness in rat streptozotocin (STZ) model of diabetic retinopathy (DR). Invest. Ophthalmol. Vis. Sci. (submitted).
  2. Trivedi, R. and Kompella, U.B.* Nanomicellar formulations for sustained drug delivery: Strategies and underlying principles. Nanomedicine (submitted).
  3. Sundaram S, Trivedi R, Durairaj C, Ramesh R, Ambati BK, Kompella UB. Targeted drug and gene delivery systems for lung cancer therapy. Clin Cancer Res. 2009 Dec 1;15(23):7299-308. Epub 2009 Nov 17. PubMed PMID: 19920099; PubMed Central PMCID: PMC2787834.

Puneet Tyagi

Puneet Tyagi: Graduate Student
Phone: 303.724.4026
Puneet’s research focuses on the efficacy of Tumstatin in treating choroidal neovascularization of the eye.

Sunil Vooturi

Sunil Vooturi: Post Doctoral Fellow
Phone: 303.724.4026
Sunil’s research focuses on the development, design, and synthesis of prodrugs for improving the transport into the posterior region of the eye.