The High Throughput and High Content Screening (HTS/HCS) Core Facility specializes in chemical biology as it relates to drug discovery, biological probe discovery, and phenotypic characterization of small-molecule effects on cellular systems. In addition to housing the instrumentation and robotics required for traditional HTS, the Core houses a cutting-edge High Content image-based system for next-generation small-molecule discovery research and analysis in fixed or live cells and cellular systems.
The HTS/HCS Core is designed as a resource for the screening of small-molecule compound libraries in any cellular or biochemical assay system. For a detailed summary of the steps in a typical screening campaign, please see HTS and HCS information and resources. In addition to small-molecule screening, the instrumentation in the HTS/HCS Core is available on an hourly basis with nominal charges. A small fee is charged for training on each instrument (see costs and authorship for details).
The HTS/HCS Core Facility is located on the Anschutz Medical Campus of the University of Colorado, in the new Pharmacy and Pharmaceutical Sciences building. Startup funding for the HTS/HCS Core Facility has been provided by the Colorado Office of Economic Development and International Trade (COEDIT), through the Bioscience Discovery Evaluation Grant Program (BDEGP).
HTS Assay Technologies
HCS Assay Technologies
HTS and HCS Information and Resources
Costs and Authorship