University of Colorado School of Pharmacy
Mail Stop C238
12850 E. Montview Blvd.
Aurora, CO 80045
Research 2 (P15)
Research 2 (P15)
- Faculty Fellow, Institute for Behavioral Genetics
Training and Education:
- BS, Virginia Tech. Blacksburg, Virginia
- PhD, University of Colorado Denver, Denver, Colorado (Pharmaceutical Sciences).
The basic goal of the lab is to map out neuronal pathways that influence behavior related to drug and alcohol abuse with an emphasis on the role of genetics. We use a wide variety of methods including quantitative trait loci (QTL) mapping, gene expression microarray analysis, Next Generation sequencing methods such as RNA-seq, various neurochemical assays, and behavioral testing.
The work is conducted primarily in genetically defined strains of mice and rats. A major focus of the lab is in defining the role of CNS gene expression in genetic differences in acute alcohol sensitivity and tolerance, and how that contributes to pathological alcohol-seeking behavior.
- Professional Program: Physiology, Pharmacology
- Graduate Program: Neurotoxicology, Drug Metabolism, Pharmacogenetics
- Radcliffe, R. A., Floyd, K. L., Drahnak, J. A., and Deitrich, R. A. Genetic dissociation between ethanol sensitivity and rapid tolerance in mouse and rat strains selectively bred for differential ethanol sensitivity. Alcohol Clin Exp Res 29:1580-1589, 2005.
- Radcliffe, R. A., Lee, M. J., and Williams, R. W. Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mamm Genome 17:629-642, 2006.
- Radcliffe, R. A., Floyd, K. L., and Lee, M. J. Rapid ethanol tolerance mediated by adaptations in acute tolerance in inbred mouse strains. Pharmacol Biochem Behav Pharmacol Biochem Behav 84:524-534, 2006.
- Radcliffe R. A., Erwin, V. G., Bludeau, P., Deng, X-S., Fay, T, Floyd, K. L., and Deitrich, R. A. A major QTL for acute ethanol sensitivity in the Alcohol Tolerant and Non-Tolerant selected rat lines. Genes Brain Behav 8:611-625, 2009.