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University of Colorado Denver

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Richard Radcliffe, PhD

Professor of Pharmacology, Department of Pharmaceutical Sciences


Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-3124
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Third Floor
Room 3124

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Third Floor
Rooms 3124, 3263, 3460-D, 3460-F, 3460-G, 3460-H

Contact:

Affiliation:

  • Human Medical Genetics and Genomics Program
  • Toxicology Program
  • Faculty Fellow, Institute for Behavioral Genetics

Training and Education:

  • BS, Virginia Tech. Blacksburg, Virginia
  • PhD, University of Colorado Denver, Denver, Colorado (Pharmaceutical Sciences, Dr. V. Gene Erwin)
  • Post-doctoral training, Behavior Genetics, University of Colorado Anschutz Medical Campus (Dr. Richard Deitrich)
  • Sabbatical training, Deep Sequencing Computation and Analysis, BioFrontiers Institute (Dr. Robin Dowell)

Research Interests:

The basic goal of the lab is to map out neuronal pathways that influence behavior related to drug and alcohol abuse with an emphasis on the role of genetics. We use a wide variety of methods including quantitative trait loci (QTL) mapping, gene expression microarray analysis, Next Generation sequencing methods such as RNA-seq, various neurochemical assays, and behavioral testing.

The work is conducted primarily in genetically defined strains of mice and rats. A major focus of the lab is in defining the role of CNS gene expression in genetic differences in acute alcohol sensitivity and tolerance, and how that contributes to pathological alcohol-seeking behavior.

Teaching:

  • Professional Program: Physiology, Pharmacology
  • Graduate Program: Neurotoxicology, Drug Metabolism, Pharmacogenetics

Representative Publications:

  • Radcliffe RA, Lee MJ, Williams RW (2006) Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mamm Genome 17:629-642. 
  • Radcliffe RA, Floyd KL, Lee MJ (2006) Rapid ethanol tolerance mediated by adaptations in acute tolerance in inbred mouse strains. Pharmacol Biochem Behav 84:524-534.  
  • Bowers BJ, Radcliffe RA, Smith AM, Wehner JM (2006) Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCγ mice. Alcohol 40:19-33.   
  • Botta P, Mameli M, Floyd KL, Radcliffe RA, Valenzuela CF (2007) Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not affected by a single amino acid change (R100Q) in the α6 GABAA receptor subunit. J Pharmacol  Exp Ther 323:684-691. 
  • Radcliffe RA, Erwin VG, Bludeau P, Deng X-S, Fay T, Floyd KL, Deitrich RA (2009) A major QTL for acute ethanol sensitivity in the Alcohol Tolerant and Non-Tolerant selected rat lines. Genes Brain Behav 8:611-625.
  • Good RL, Radcliffe RA (2011) Methamphetamine-induced locomotor changes are dependent on age, dose and genotype. Pharmacol Biochem Behav 98:101-111.
  • Phang TL, Feng W, Radcliffe RA, Kechris KJ (2011) Post-processing multi-treatment time-course microarray studies using the Johnson-Neyman procedure. BioSIM  2:107-126.
  • Darlington TM, Ehringer MA, Larson C, Phang TL, Radcliffe RA (2013) Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice. Genes Brain Behav 12:263-274.
  • Gritz SM, Radcliffe RA (2013) Genetic Effects of ATP1A2 in Familial Hemiplegic Migraine Type II and Animal Models. Human Genomics 7:8.
  • Radcliffe RA, Bennett B, Larson C (2013) Genetic studies of acute tolerance, rapid tolerance, and drinking in the dark in the LXS recombinant inbred strains. Alcohol Clin Exp Res 37:2019-2018.