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University of Colorado Denver

 

Daniel V. LaBarbera, PhD

Associate Professor of Drug Discovery and Medicinal Chemistry and Director of the High-Throughput Screening and Chemical Biology Core Facility


CU AMC Affiliations

Adjunct Faculty, Department of Ophthalmology, School of Medicine
Full Member, CU Cancer Center, Developmental Therapeutics Program
Faculty Member, Structural Biology and Biochemistry Graduate Program
Faculty Member, University of Colorado Denver, Chemistry Graduate Program

Mailing Address and Contact Information

University of Colorado Anschutz Medical Campus
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd.
Office Location: V20-2101
Aurora, CO 80045
Office Phone: 303-724-4116
Fax: 303-724-7266
E-Mail: Daniel.LaBarbera@ucdenver.edu

Lab Locations and Contact Information

LaBarbera Lab Location: V20-2420B
LaBarbera Lab Phone: 303-724-4166

HTS Lab Location: V20-2211
HTS Lab Phone: 303-724-4166

Websites

LaBarbera Lab (Under Construction)
High-Throughput Screening and Chemical Biology Core Facility

Training and Education

Dr. LaBarbera received his bachelor’s degree in biochemistry from Arizona State University (ASU). As an undergraduate he received a grant from the Howard Hughes Medical Institute to conduct undergraduate research in the laboratory of Edward B. Skibo focused on medicinal chemistry (1999-2001). In 2001, he continued his education at ASU as a graduate student with Professor Skibo focused on the synthesis and mechanistic studies of antitumor agents from nature. After completing his PhD in 2005, he moved to the University of Utah (U) where he trained in the laboratory of Professor Chris M. Ireland in natural products drug discovery. While at the U he received a National Research Service Award (NRSA) postdoctoral fellowship from the National Institutes of Health (NIH) to conduct multidisciplinary cancer research through the Huntsman Cancer Institute. This diversified training focused on medicinal chemistry and cancer biology, including: high-throughput screening (HTS) assay development, 3D tissue culture models, in vitro and in vivo mechanism of action studies, total synthesis of natural products, and isolation and structure elucidation of natural products. In 2008, he joined the faculty at the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Research Overview

Dr. LaBarbera’s laboratory is engaged in preclinical drug discovery and development aimed at translating effective therapies targeting cancer, diabetes, and microbial infection. A major focus is to identify novel therapeutics that specifically target the mechanisms controlling aberrant epithelial-mesenchymal transition (EMT). EMT is linked to the pathology of the most prominent human diseases, including: fibrosis, diabetes, and cancer progression and metastasis. The LaBarbera lab uses a multidisciplinary approach to accomplish encompassing high-throughput and high-content screening (HTS/HCS) to identify small molecule probes or lead therapeutic agents; 3D tissue culture models for HTS/HCS discovery, natural products small molecule library development, medicinal chemistry, pharmacology, and mechanism of action studies with lead compounds. Please visit the LaBarbera lab website (currently under construction) to learn more about ongoing research projects and collaborations, lab members, and other opportunities for students and fellows.

Publications on PubMed Central

Teaching

Dr. LaBarbera teaches in both the professional and graduate student curriculum offered at the SSPPS. He is the director of PHRD 5915 modern drug design and drug action course required for P1 students in the pharmacy curriculum. In addition, he is a faculty member of the Structural Biology and Biochemistry Program through the University of Colorado AMC Graduate School. He also has an appointment as a graduate faculty in the Department of Chemistry, the University of Colorado Denver Auraria Campus.