Skip to main content
Sign In

University of Colorado Denver

​​​​​​​​​ ​
 

Rajesh Agarwal, PhD

Professor, Department of Pharmaceutical Sciences


Mailing address:

University of Colorado
Skaggs Sc​hool of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-2118
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2118

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2430/2440

Contact:

Training and Education:

  • BS (1975)-Chemistry, Biology - Lucknow University, India
  • MS (1977)-Organic Chemistry - Lucknow University, India
  • PhD (1981) Bio-Organic Chemistry - Lucknow University, India

Research Interest:

  • Prevention and Therapy of cancer: Dietary and synthetic agents - cellular, biochemical and molecular mechanisms employing biochemical and molecular
    biological techniques.  Evaluation of cancer chemopreventive potential of dietary constituents employing several long-term animal tumor bioassay protocols, and short-term animal and cell culture assays.  Models include skin, prostate, colon, bladder, ovarian and lung cancers.
  • Mechanism of cancer prevention and therapy: Oncogenes and suppressor genes, cell cycle modulation, p53, cyclins, cyclin dependent kinases, cyclin dependent kinase inhibitors, apoptosis, and mitogenic and anti-apoptotic signaling pathways.
  • Carcinogenesis - causation and mechanistic studies employing enzyme bioassay and molecular biology approaches, cell culture technique and long-term animal tumor studies.

Representative Publications:

  • Raina, R., Ravichandran, K., Rajamanickam, S., Huber, K.M., Serkova, N.J. and Agarwal, R.: Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study. Cancer Prev. Res., 6: 40-50, 2013. PMCID: PMC3662486. January 2013 Cancer Prev Res Journal Cover Page Coverage.
  • Matten, S., Raina, K., Agarwal, C., Chan, D. and Agarwal, R.: Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells. J. Pharmacol. Exptl. Ther., 345: 206-214, 2013. May 2013 J. Pharmacol. Exptl. Ther. Journal Cover Page Coverage. PMCID: PMC3629797
  • Tewari-Singh, N., Jain, A.K., Inturi, S., White, C.W. and Agarwal, R.: Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice. PLoS ONE 8(6): e67557. doi:10.1371/journal.pone.0067557, 2013. PMCID: PMC 3691145.
  • Deep, G. and Agarwal, R.: Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy. Current Cancer Drug Targets, 13:486-499, 2013. PMCID: PMC3924886
  • Deep, G., Jain, A.K., Ramteke, A., Ting, H., Vijendra, K.C., Gangar, S.C., Agarwal, C. and Agarwal, R.: SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin. Molecular Cancer, 13: 37, 2014. PMCID: PMC3937432

Keywords:

Cancer chemoprevention, phytochemicals, skin cancer, prostate cancer, silibinin, silymarin, grape seed extract, phytic acid, IP6.​