Skip to main content
Sign In
 

Tom Anchordoquy, PhD

Professor, Department of Pharmaceutical Sciences


Mailing address:

University of Colorado School of Pharmacy
Mail Stop C238
12850 E. Montview Blvd. V20-4120
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4120

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4440A

Contact:

Affiliations:

  • Member, Center for Pharmaceutical Biotechnology
  • Member, University of Colorado Cancer Center

Training and Education:

  • BS, Oregon State University (Biology)
  • MA, PhD, University of California at Davis (Zoology)
  • Postdoctoral Fellow, University of Colorado at Boulder and University of Colorado Denver.

Research Interest:

My laboratory focuses on the development of synthetic delivery systems for use in nucleic acids-based therapies (e.g., gene, siRNA, antisense, aptamers).  Our most recent work focuses on understanding the immune responses elicited after intravenous administration of different nanoparticle formulations. Ultimately, the goal of these studies is to develop lipid-based delivery systems that elicit minimal immune responses upon repeat administration and preferentially target tumors.

Another major focus in the lab is the use of exosomes and the exosomal pathway for drug delivery. We recently began a project in which exosomes from cow milk are used to orally administer chemotherapeutics that typically require intravenous infusion. Studies on our delivery systems include biophysical characterization, pharmaceutical optimization, cell culture assessment, and ultimately testing in animal models.

In addition, we have conducted many studies on the stability of delivery systems during physical stresses, e.g., freezing and drying. The goal of this research is to develop formulations for therapeutic use that will be stable on a pharmaceutically-relevant timescale (~ 2 years). While many of our previous studies have involved acute stresses, our more recent work has focused on prolonged storage of polynucleotides and delivery systems in the dried state.

Our laboratory also conducts traditional pharmaceutical research involving the formulation and delivery of small molecule therapeutics. This latter research is very translational in nature, and our efforts have led to a commercially-available topical formulation (Difinsa53®) used to protect skin during radiation therapy.

Teaching:

  • Professional Program: Pharmaceutics, Compounding
  • Graduate Program: Liposome-based Drug Delivery, Drug Development

Representative Publications:

  • Betker JL, Angle BM, Graner MW, Anchordoquy TJ.  The Potential of Exosomes from Cow Milk for Oral Delivery. J. Pharm. Sci. (in press).
  • Betker JL, Jones D, Childs CR, Helm KM, Terrell K, Nagel MA, Anchordoquy TJ. Nanoparticle uptake by circulating leukocytes: A major barrier to tumor delivery. J. Cont. Rel. 286:85-93 (2018).
  • Anchordoquy TJ and Simberg D. Watching the Gorilla and Questioning Delivery Dogma. J. Cont. Release 262:87-90 (2017).
  • Betker JL, Anchordoquy TJ. Non-Additive Effects of Repetitive Administration of Lipoplexes in Immunocompetent Mice. J. Pharm. Sci. 106(3):872-881 (2017)  doi: 10.1016/j.xphs.2016.11.013
  • Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes.  J. Cont. Release 199:145-155 (2015).
  • Betker JL, Anchordoquy TJ. Relating Toxicity to Transfection: Using Sphingosine to Maintain Prolonged Expression In Vitro. Mol. Pharm. 12:264-73 (2015) PMID: 25418523 PMCID# PMC4291780
  • Payton, NM, Wempe MF, Xu Y, Anchordoquy TJ. Long Term Storage of Lyophilized Liposomal Formulations. J. Pharm. Sci. 103:3869–3878 (2014).
  • Verhoef JJF and Anchordoquy TJ. Questioning the Use of PEGylation for Drug Delivery. Drug Delivery and Translational Res. 3:499-503 (2013).

​​​​​​