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University of Colorado Denver

 

Mechanisms and Barriers in Nanomedicine

Breckenridge, CO, July 14-16, 2016


There is a growing sentiment in the field that in order to increase the availability of nanodrugs for patients, the biological, pathophysiological, immunological and manufacturing/regulatory barriers to effective translation need to be addressed.

The goals of the two-day Mechanisms and Barriers in Nanomedicine workshop are to: 

  • provide an educational forum on the barriers to nanoparticle translation; 
  • provide a paradigm shift to overcome these problems; and
  • allow for open discussion among faculty, postdocs and graduate students, to trigger new ideas and concepts.

The workshop will consist of informal, non-concurrent sessions, followed by discussion. Talks will focus on mechanisms, problems, and solutions of the following aspects of nanomedicine:

  • bio-nano interface, immune recognition, and toxicity
  • complement
  • ​in vitro and in vivo barriers
  • no-engineering and design
  • ​metastatic cells, stem cells, and relevance of mouse models
  • regulatory/industrial hurdles

Discussions will focus on questions suggested by the audience.

Submit an Abstract, Topic, or Question

Students, faculty, and postdocs are invited to submit abstracts for posters on mechanistic studies focused on problems in nanomedicine. Of those, one poster abstract will be selected for a brief oral presentation. The remaining abstracts will be presented as posters, with the best poster receiving a prize. The deadline has been extended for post-docs and graduate students through June 30, 2016. To submit and abstract, email dmitri.simberg@ucdenver.edu​.

Attendees are also welcome to submit a provocative topic/question for the discussion session to the organizers via email​.

An informal atmosphere, wine, and food are guaranteed. To register, please click on the "Registration" tab below. See you in beautiful Colorado!


Thursday, July 14



Arrival and registration

Aerial gondola tour and mountain hike for early arrivers

7-10 pm Welcome reception (wine and hors d'oeuvres) 

Friday, July 15



7-8:30 am Breakfast

​8:30 am 8:35 am​ Welcome from organizers​ Anchordoquy/Farhangrazi/Moghimi/Simberg​
​8:35 am 8:45 am​ ​Fundamental issues in nanomedicine Anchordoquy​
 

Morning session 1: Immunological barriers, macrophages and toxicity (Chair: D. Peer)

​8:45 am 9:10 am​ Nanosafety: No small issue​ Moien Moghimi​
​9:15 am 9:40 am​ Macrophage reprogramming with nanoparticles​ Diana Boraschi​
​9:45 am 10:05 am​ Complement and immune uptake of nanomedicines: Lessons from iron oxide nanworms​ Dmitri Simberg​

10:10-10:30 am Coffee break and poster viewing

Morning session 2: Tumor barriers and targets (Chair: P. Decuzzi)

​10:30 am 11:05 am​ Keynote: Tumor-penetrating peptides in nanoparticle targeting​ Erkki Ruoslahti​
11:10 am​ 11:40 am​ Where the wild things are: Perivascular regulation of tumor cell dormancy and drug resistance​ Cyrus Ghajar​
11:45 am​ 12:05 pm​ ​Immunotherapy targeting tumor microenvironment and opportunities for nanomedicine Stephen Dow​

12:10-2:10 pm Lunch

Afternoon session 1: Targeting tumor microenvironment (Chair: SM. Moghimi)

​2:10 pm 2:40 pm​ Improving nano-drugs' therapeutic efficacy through their interaction with tumor microenvironment​ Chezy Barenholz​
2:45 pm​ 3:05 pm​ Nanobioconjugates delivered through multiple biobarriers regulate laminin-411 - Notch pathways​ Julia Ljubimova​
3:10 pm​ 3:30 pm​ Exploting cells in the tumor microenvironment for nanovector based therapy​ Biana Godin​

3:35-3:55 pm Coffee break and poster viewing

Afternoon session 2: Formulation barriers (Chair: H. Haas)

​3:55 pm ​4:20 pm The 4S parameters in the rational design of nanomedicines​ Paolo Decuzzi​
4:25 pm​ 4:50 pm​ Overcoming barriers for nanoparticle delivery using circulatory cells​ ​Samir Mitragotri
​4:55 pm 5:20 pm​ Biologics and peptides by a novel encapsulation process​ Robert Prud'homme​

5:25-6:25 pm Discussion and snacks

Dinner in Breckenridge on your own 

Saturday, July 16



7-8:30 am Breakfast

Morning session 1: Clinical aspects of nanomedicine (Chair: D. Simberg)

​8:30 am ​9 am Optimizing nanoparticle delivery of chemotherapeutics - The clinical challenge​ Alberto Gabizon​
9:05 am​ 9:30 am​ Impact of nanoparticles on the tumor immunologic millieu: Promise and peril​ Irene La-Beck​
9:35 am​ 9:55 am​ Nanoparticle-based MRI on tumor associated macrophages: Preclinical and clinical utility​ Natalie Serkova​

10-10:20 am Coffee break and poster viewing

Morning session 2: Manufacturing and regulatory/funding hurdles (Chair: S. Farhangrazi)

​10:20 am ​10:30 am Challenges and opportunities in Nano-commercialization​ Shadi Farhangrazi​
10:35 am​ 11:05 am​ Translation of a cancer nanotherapeutic into the clinic: A view from the trenches​ Len Pagliaro​
11:10 am​ 11:30 am​ Preclinical immunotoxicity studies of nanotechnolog​y-formulated drugs​ Marina Dobrovolskaia​
11:35 am​ 11:50 am​ Perspective on nanomedicine climate and the science advances​ Dorothy Farrell​

11:55-1:55 pm Lunch 

Afternoon session 1: Organ/tissue/cell-specific barriers (Chair: H. Ghandehari)

​1:55 pm ​2:20 pm Biophysical barriers in respiratory drug delivery​ Hugh Smyth​
2:25 pm​ 2:50 pm​ To target or not to target: Lessons from RNAi-based targeted lipid-based nanoparticles​ Dan Peer​
2:55 pm​ 3:20 pm​ Physical and chemical mechanisms of targeting selectivity for mRNA nanomedicines for tumor immunotherapy​ Heinrich Haas​

3:25-3:45 pm Coffee break and poster viewing

Afternoon session 2: Innovative approaches and formulations (Chair: R. Prud'homme)

​3:45 pm ​4:05 pm Hyperthermia approaches for enhanced delivery of polymer therapeutics​ Hamid Ghandehari​
​4:10 pm 4:30 pm​ Extracellular vesicles-mediated penetration of therapeutic compounds in solid tumors​ Ji Ho (Joe) Park​
4:35 pm​ 4:55 pm​ Nanoparticle-prodrug combination approach for treating neuroblastoma ​ Michael Chorny​
5:00 pm​ 5:20 pm​ Nanoghosts as a natural nonviral gene delivery platform for targeting cancers​ Marcelle Machlouf​
 

5:25-6:25 pm Discussion and snacks

6:35 pm Farewell dinner

Adjourn 

​​​

Registration fee includes coffee breaks, reception, farewell dinner, and all meals, with the exception of dinner on July 15.

Registration Fees:

​Delegate Early Bird (April 30, 2016)​ After April 30, 2016​
Students/Postdocs ​$350* ​$450
Regular Attendee  ​ ​$560 ​$660
 

*Student early bird deadline extended to June 30, 2016.

**Meals for accompanying family members to be announced.

Register now

Cancellations:

  • Before May 1, 2016: Full Refund minus $30 processing fee
  • May 1-June 15, 2016: 50% Refund
  • After June 15, 2016: No Refund
The organizers are offering reduced rates to students and postdocs. Room reservation is separate from the conference reservation. After completing the registration, please vist the Travel and Accommodation tab for information on hotel reservations. 

Accommodations

The workshop will be held at the Beaver ​Run Resort and Conference Center in Breckenridge, Colorado – a beautiful ski resort town in the Rocky Mountains.

Beaver Run Resort and Conference Center is a full-service property featuring over 500 unique lodging units (individually owned and decorated, from single rooms to family suites). It is the largest conference center in Breckenridge a​nd offers a variety of resort amenities including a swimming pool and spas.

A block of rooms for the workshop has been reserved at a discounted rate. 

  • Make an online reservation. On the left side of the reservation screen, under "Select Your Dates," you will see the group name: Mechanisms & Barriers. 

If you need a special accommodation (condo, family, disability, etc.), please call (800) 525-2253 and reference the "Mechanisms and Barriers in Nanomedicine Conference" to receive the group rate.

Travel

Typical driving distance from the Denver International Airport (DIA) to Breckenridge, Colorado, is about 1 hour and 45 minutes. There are many shuttle services offering routes from DIA to Breckenridge ranging in rates from $45-$65. Here are a few:

Organizers will reserve a disounted rate for the shuttle returning to the airport on Sunday. 

Venue

The town of Breckenridge offers a variety of shops, historic sites, and over 150 restaurants and bars. With average daytime temperatures in the mid-70’s and 10% humidity, it is an ideal area for a variety of outdoor activities, including whitewater rafting, mountain or road cycling, jeep and ATV tours, zip line adventures, climbing 14ers or horseback riding. For a more relaxing day, there is a golf course, fly fishing, or hiking.

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For questions or to learn more about the workshop, contact Dmitri Simberg​, Thomas Anchordoquy​, Moien Moghimi, or Shadi Farhangrazi.  ​​​​​

Thomas Anchordoquy, University of Colorado, US
Chezy Barenholz, The Hebrew University of Jerusalem, Israel
Diana Boraschi, National Research Council, Italy
Michael Chorny, Children's Hospital of Philadelphia, US
Paolo Decuzzi, Italian Institute of Technology in Genoa, Italy
Marina Dobrovolskaia, Nanotechnology Characterization Laboratory, US
Stephen Dow, Colorado State University, US
​Shadi Farhangrazi, Biotrends International and University of Denver​, US
Dorothy Farrell, National Cancer Institute​, US
Alberto Gabizon, The Hebrew University of Jerusalem​, Israel
Cyrus Ghajar, Fred Hutchinson Cancer Research Center, US
Hamid Ghandehari, University of Utah, US
Heinrich Haas, BioNTech RNA Pharmaceuticals GmbH, Germany
Irene La-Beck, Texas Tech University, US
Julia Ljubimova, Cedars-Sinai Hospital, US
Gabriel Lopez-Berestein, MD Anderson Cancer Center, US
Marcelle Machlouf, Tel Aviv University, Israel
Samir Mitragotri, University of California, Santa Barbara, US
Moien Moghimi, Durham University, UK
Len Pagliaro, Siva Therapeutics, US
Ji Ho Park, Kaist, South Korea
Dan Peer, Tel Aviv University, Israel​
Robert Prud'homme, Princeton University, US
Erkki Ruoslahti, Prebys-Sanford-Burnham, US
Natalie Serkova, University of Colorado, US
Dmitri Simberg, University of Colorado, US
Hugh Smyth, University of Texas at Austin, US
Biana Godin Vilentchouk, Methodist Hospital​​​​​​, US



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Event Sponsors

CU School of Pharmacy     CU Cancer Center     Quidel     

The AAPS Rocky Mountain regional discussion group (RMDG) is also a sponsor.