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Clinical Trials

Volunteer to Be Part of a Research Study


You can search for specific diseases or conditions in our Clinical Trials list (the page takes a few seconds to load due to the quantity of trials).

Page through all School of Medicine clinical and research trials below, or click here to look for specific types of trials.
(It will take a few seconds to load) There are two categories: 

  • Detailed Trial Descriptions, submitted by researchers, includes trial specifics and contact information.

  • Additional Clinical Trials, which include basic study details. To contact the researcher either Google the PI (primary investigator) name or use our campus directory.

If you are a researcher seeking volunteers and your study is not posted, please submit your Web ad here.  

Detailed Trial Descriptions

 Results From Research and Clinical Trials : Selected site
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COMIRB Approved Advertisement TitleStudy GoalsEligibility CriteriaDate Posted
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Brown Adipose Tissue and Estrogen (BATE Study)
To investigate whether estrogen influences the activity of brown adipose tissue.
Healthy non-smoking women 20-40 who have regular menstrual cycles and are not on hormonal contraceptives and exercise more than once per week
4/15/2014
Is your asthma well controlled?
Comparison study involving three FDA approved medications for asthma
Asthmatics 12 and over with symptoms that are well controlled and do not smoke.
4/15/2014
Do you have asthma?
Effects of a CPAP machine on asthma symptoms
Asthmatics 15-90 who do not smoke
4/15/2014
Type 2 Diabetes and Exercise Research Study
Perceived exertion during exercise
Person 50-70 with or without Type 2 diabetes who exercise vigorously less than one hour per week and have normal blood pressure.  You should have a BMI between 25-35 and have not smoked for a least one year.
4/15/2014
Is your child 6-18 years old and interested in participating in a research study?
To study the effects of polycystic kidney disease (PKD) on blood vessel function
Children 6-22 free from kidney disease and other chronic diseases
4/15/2014
Evaluation of Glucose Sensor and Insulin Infusion Set Failures: Lipohypertrophy Study
This study is looking at evaluating Insulin Pump Infusion sites and Continuous Glucose Monitoring sites in tissue with Lipohypertrophy. We will also be looking at using the sites for a longer duration.
Lipohypertrophy site of 3 cm or greater in diameter Ages 12-45 inclusive A1C Value of < 10% Insulin pump use of at least 3 month duration Pump use with Medtronic, Animas or T-slim Willing to wear two CGM's during the 4 weeks of the study
4/15/2014
Healthy subjects needed for high altitude research study
For a research study on how intracranial pressure is related to acute mountain sickness
Between the ages of 18-40 years old - Do not smoke - Engage in regular physical exercise - Willing and able to engage in moderate physical activities in a simulated high altitude environment
4/15/2014
Are you trying to lose weight?
Volunteers needed for a research study about the weight loss medication Phentermine  
Healthy and between 30-45 years of age •Have a BMI between 30 and 40 (calculate your BMI at http://www.nhlbisupport.com/bmi/) •Willing to take the weight loss medication Phentermine for a period of 8 weeks (but not currently taking any approved or investigational medication for weight loss)
4/15/2014
Help us learn about Schizophrenia!
Help us learn more about a new drug that may improve thinking and concentration in people with schizophrenia.
Healthy male and female adults, 18-50 years old with no previous or current mental illness. No drug use. Nonsmokers. If female, willing to use birth control.
4/15/2014
Volunteers With Neck Pain Needed for Research Study
The purpose of the study is to evaluate the effect of mental concentration on nerve and muscle excitability.
Men and women aged 21-50 years with a history of neck pain that is worsened by work or other stressful activities.
4/15/2014
Shingles Vaccine Clinical Research Trial
This study will compare responses to two shingles vaccines - the current FDA approved shingles vaccine and an investigational shingles vaccine - in younger and older people.
50-59 years of age or 70-85 years of age; General good health; No prior history of shingles; Have never received the shingles vaccine; although... a subset of 70-85 year olds who DID receive the shingles vaccine at least 5 years previously is also needed (must be able to provide documentation of vaccination)
4/15/2014
Volunteers needed for a research study of men who are carriers of the Fragile X gene
Study the effects of the Fragile X Tremor-Ataxia Syndrome (FXTAS) on mental abilities and brain functioning.  A better understanding of FXTAS should lead to improved diagnosis, and eventually to means of treating both the symptoms and the disease.
Men age 62 or above who have a least 12 years of education and who have no neurological disorders.
4/14/2014
Are you stopping your birth control because you want to become pregnant?
To look at contraception rates after birth control discontinuation.
Women 18-35 who are planning to, or have recently stopped their birth control because they want to become pregnant.
4/14/2014
Healthy Postmenopausal Women needed to participate in a research study
To test whether estrogen has different effects on blood sugar early in menopause compared to many years after menopause​.​
Women 45-70 who have gone through menopause within the past 6 years or are more than 10 years past menopause, never used hormone therapy for more than 6 months and are willing to use estrogen patches for 1 week.  Must be a non-smoker and sedentary to moderately active.
4/14/2014
Type 1 Diabetes Research Study
To study the effects of a medication on metabolism and blood vessel function.
Persons 25-50 years old with or without type 1 diabetes with normal blood pressure and exercise vigorously no greater than 3 times per week.
4/14/2014
JUST DIAGNOSED WITH SHINGLES?
This study will look at the body's immune response (how the body fights infection) to the onset of shingles. 1-2 study visits for blood draws, over the course of 3 months.
18+ years of age; NO PRIOR HISTORY of shingles; have NEVER received the shingles vaccine; have DEVELOPED SHINGLES within the last 10 days.
4/14/2014
Diabetic Male and Female Volunteers Needed for Exercise Research Study
Evaluate exercise function during single leg calf exercise in people with or without type 2 diabetes
Healthy Adults 30-70 with Type 2 diabetes but not using insulin.  Must be a non-smoker who exercise no more than one time per week and have a BMI of 25-40
4/11/2014
Trouble Controlling your Type 2 Diabetes?
Investigational non-surgical device that may help decrease blood sugar.
Adults 21-65 with type 2 Diabetes and not on oral medication, not taking insulin. Must have an A1C level of 8-10%, be overweight or obese and willing to attend study visits
4/11/2014
Problems with Schizophrenia and Cocaine?
determine whether a medication may help reduce or eliminate cocaine use in people diagnosed with schizophrenia.
Persons who have been diagnosed with schizophrenia and use cocaine.
4/11/2014
Project Safe - THE IMPACT OF MEDICAL MARIJUANA IN METROPOLITAN DENVER
To learn more about the medical marijuana industry in Colorado and its relationship to health risk behaviors and healthcare.
Persons 18+ currently a medical marijuana patient or currently using non-medical marijuana
4/11/2014
Persons with active, moderate to severe ulcerative colitis needed
This study is being conducted to investigate the efficacy of methotrexate in treating ulcerative colitis in patients that have active, moderate to severe colitis and have failed other types of therapies.
Inclusion: Ages 18-70 Ulcerative colitis has been diagnoses by routine criteria At least one of the following applies: steroid dependent failed 5-ASA (mesalamine) therapy, such as Asacol Failed/lost response to infliximab (Remicade) Intolerant/unresponsive to azathioprine (Imuran) or 6-MP (purinethol) therapy Exclusion (partial): Existing pregnancy, lactation, or planned pregnancy (men and women)
4/11/2014
3D Gait Analysis Participants Needed
Research study investigating the coordination of walking
Subject with Spastic Cerebral Palsy Inclusion Criteria: ● Males and females between the ages of 7 and 100 years of age. ● Retrospective gait data must contain a complete lower body marker set and valid kinetic data. ● Only gait data trials of the subject walking unassisted will be used. ● Diagnosis of spastic cerebral palsy. ● Exhibits either stiff knee gait pattern, characterized by insufficient and delayed peak knee flexion during swing (less than 45), or crouch gait pattern, characterized by excessive hip flexion and knee flexion (greater than 30 throughout stance). Cerebellar Ataxic Gait Subject Inclusion Criteria: ● Males and females between the ages of 7 and 100 years of age. ● Ability to walk continuously and unassisted for 3 minutes. ● If under the age of 18, parent consent and subject assent. ● Diagnosis of either Friedreich's or spinocerebellar ataxia. Subject with Lower Limb Amputation Inclusion Criteria: ● Males and females between the ages of 7 and 100 years of age. ● Ability to walk continuously and unassisted for 3 minutes. ● If under the age of 18, parent consent and subject assent. ● Has been using the prosthetic limb for at least 6 months for independent ambulation prior to gait analysis at CGMA. ● Below knee or above knee amputation.
4/11/2014
Help us learn about a new investigational basal insulin!
You or your child may be eligible to participate in a research study at the Barbara Davis Center to learn more about a investigational new basal insulin.
1 - Have Type 1 Diabetes
2 - Are between 1 and 17 years old
3 - Have been using insulin for at least 3 months
4 - Are willing to participate in a 18 week study
4/11/2014
Be Influential - Influenza Study
Doctors at the National Institutes of Health are conducting a research study (IRC-003) to investigate whether treating the influenza virus (flu) with a combination of drugs is better than the standard therapy with one drug.
Volunteers may be male or female and must: -be at least 18 years old -have a history of an influenza-like illness (typically this would consist of a fever, cough, and aches) -have an onset of illness within the past 96 hours -have a medical condition(s) that has been associated with increased risk of complications from influenza
4/11/2014
Would you like to participate in a study to improve the understanding of how emotions and symptom distress affect adherence to hormonal therapy in breast cancer?
The purpose of this study is to understand how emotional factors and symptom distress affect adherence to hormonal therapy in women that have completed all other treatment for breast cancer.   
Women Breast Cancer Survivor Age 21-70 years old Within 24 months of starting hormonal therapy: Aromatase Inhibitors or Tamoxifen (Aromatase Inhibitors, Exemestane (aromasin), Letrolzole (Femara), Anastrozole (Arimidex).
4/11/2014
Seeking Healthy Women Ages 18-35 for Birth Control Study
The University of Colorado School of Medicine is Seeking generally healthy women for a research study of a new birth control pill.
Generally healthy women ages 18-35
4/11/2014
Are you a Woman with PCOS?
To examine health related quality of life issues and coping strategies in women w/polycystic ovary syndrome.
Women 18-40 diagnosed with PCOS and not pregnant
4/10/2014
Women needed for Research Study
To examine how BMI affects fertility
Healthy women 18-39 with a BMI greater than 30 with regular menstrual cycles and not pregnant or trying to conceive and not on any hormones (like birth control).  Must be willing to collect your first morning urine daily for one menstrual cycle and provide blood samples.
4/10/2014
Are you taking medications for diabetes and resulting kidney complications?
To evaluate a new investigational drug for people with Type 2 diabetes and kidney disease.
Person 18+ who are not of child bearing potential (f female) with type 2 diabetes and currently taking medication for kidney disease. You must be able to attend at least 6 office visits over 16 weeks.
4/10/2014
Apoyo con Cariño: Improving Palliative Care for Latinos with Cancer
We want to understand if a patient navigator can help Latino patients and their family caregivers deal with cancer. Our project hopes to improve palliative or comfort care to patients with advanced cancer. The goal is to prevent or relieve suffering for people facing serious illness. Research is needed to find out if a patient navigator can help patients and family caregivers.
Adults (18 years and older) who self-identify as Latino and have Stage III-IV cancer.
4/10/2014

​Additional Clinical Trails

 Results From Research : Selected site
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Engineering Clinical Evaluation of Philips Medical's Modified CX50 with Revision MI 3 Software and Q-Station Software with new Release 9.0.Sponsor Protocol Philips Medical. WIRB Protocol No. 20110948
Salcedo, Ernesto11-0797
Adult Congenital Heart Disease Quality Enhancement Research Initiative (ACHD QuERI). Sponsor Protocol CHRC2011-ACHD001. WIRB Protocol No. 20111582
Kay, Joseph12-1161
The Targeting Acute Congestion with Tolvaptan in Congesting Heart Failure Study (Tactics-HF). WIRB Protocol No. 20121793
Shakar, Simon13-0112
ASPIRE Early Ablation Therapy for the Treatment of Ischemic Ventricular Tachycardia in Patients with Implantable Cardioverter Defibrillators. WIRB Protocol No.20121193
Tzou, Wendy13-0280
A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL STUDY TO COMPARE THE EFFICACY AND SAFETY OF POMALIDOMIDE, BORTEZOMIB AND LOW-DOSE DEXAMETHASONE VERSUS BORTEZOMIB AND LOW-DOSE DEXAMETHASONE IN SUBJECTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA. Sponsor Protocol # CC-4047-MM-007. WIRB Protocol # 20121754
Smith, Clayton13-2056
Exhibit B-14 Specific Research Plan for Voyager 1.0. WIRB Protocol # 20131141
Salcedo, Ernesto13-2062
A Single-arm Study to Assess the Efficacy and Safety of Oral Rigosertib in Transfusion-dependent, Low or Intermediate-1, Myelodysplastic Syndrome Patients Based on the International Prognostic Scoring System. Sponsor Protocol # 09-07. WIRB Protocol # 20131128
Pollyea, Daniel13-2064
COMBI-AD: A phase III randomized double blind study of dabrafenib (GSK2118436) in COMBInation with trametinib (GSK1120212) versus two placebos in the ADjuvant treatment of high-risk BRAF V600 mutation-positive melanoma after surgical resection. Sponsor Protocol # BRF115532. WIRB Protocol # 20130566
Gonzalez, Rene13-2093
A PROSPECTIVE, RANDOMIZED, CONTROLLED, PARALLEL GROUPS, MULTICENTER POST-APPROVAL STUDY OF THE GLAUKOS® ISTENT® TRABECULAR MICRO-BYPASS STENT SYSTEM IN CONJUNCTION WITH CATARACT SURGERY. SPONSOR PROTOCOL # GTS100-PAS2. WIRB PROTOCOL # 20130739
Seibold, Leonard13-2098
A randomized, double blind, placebo-controlled, multicenter phase III study of regorafenib in patients with hepatocellular carcinoma (HCC) after sorafenib. Sponsor Protocol No. BAY 73-4506 / 15982. WIRB Protocol No. 20121899
Purcell, William13-2135
A Phase I Dose Escalation Open-Label Safety, Pharmacokinetic and Pharmacodynamic Study to Determine the Recommended Phase II Dose of GSK1120212 Dosed in Combination with GSK2141795. Sponsor Protocol No. TAC113886. WIRB Protocol No. 20130890
Gonzalez, Rene13-2146
A Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Vilazodone in Adolescent Patients with Major Depressive Disorder. Sponsor Protocol No. VLZ-MD-21. WIRB Protocol No. 20130945
Wamboldt, Marianne13-2149
A Phase 2, Randomized, Multicenter Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Combined with nab-Paclitaxel Plus Gemcitabine Compared With nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Previously Untreated Pancreatic Cancer. Sponsor Protocol No. HALO-109-202. WIRB Protocol No. 20130824
Weekes, Colin13-2161
A PHASE IB OPEN-LABEL STUDY OF THE SAFETY AND PHARMACOKINETICS OF MEHD7945A IN COMBINATION WITH EITHER CISPLATIN AND 5-FU OR PACLITAXEL AND CARBOPLATIN IN PATIENTS WITH RECURRENT/METASTATIC SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK. Sponsor Protocol No. GO28909. WIRB Protocol No. 20131256
Jimeno, Antonio13-2170
A PHASE II, MULTICENTER, SINGLE-ARM STUDY OF MPDL3280A IN PATIENTS WITH PD-L1-POSITIVE LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER. Sponsor Protocol No. GO28625. WIRB Protocol No. 20130654
Camidge, David13-2173
A Multi-Center, Dose Finding, Open Label, Phase 1 Study of RX-5902 in Subjects with Advanced or Metastatic Solid Tumors. Sponsor Protocol No. RX-5902-P1-01. WIRB Protocol No. 20131320
Eckhardt, Sue13-2176
A Phase 3, Randomized, Double-Blind Study of Nivolumab Monotherapy or Nivolumab Combined with ipilimumab Versus Ipilimumab Monotherapy in Subjects with Previously Untreated Unresectable or Metastatic Melanoma. Sponsor Protocol No. CA209067. WIRB Protocol No. 20130618
Gonzalez, Rene13-2193
A Double-Blind, Placebo-Controlled, Single Ascending Intravenous Infusion Study of rHIgM22 in Patients with Multiple Sclerosis. Sponsor Protocol No. IM22-MS-1004. WIRB Protocol No. 20130406
Vollmer, Timothy13-2203
A multinational, multicenter, randomized, double-blind, parallel-group, placebo-controlled study followed by an active treatment period, to evaluate the efficacy, safety and tolerability of two doses of oral administration of laquinimod (0.6 mg/day or 1.2 mg/day) in subjects with relapsing remitting multiple sclerosis (RRMS) Sponsor Protocol No. LAQ-MS-305 (CONCERTO). WIRB Protocol No. 20130631
Vollmer, Timothy13-2209
A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® (Part A) Followed by Open-Label, Multiple-Treatment with MYOBLOC® (Part B) in the Treatment of Troublesome Sialorrhea in Adult Subjects. Sponsor Protocol No. SN-SIAL-301. WIRB Protocol No. 20131152
Klepitskaya, Olga13-2237
Evaluation of Bimatoprost 0.01% and Bimatoprost 0.03% in Patients with Glaucoma or Ocular Hypertension. Sponsor Protocol No. 192024-081. WIRB Protocol No. 20131409
Kahook, Malik13-2240
A Phase 1/2, First-In-Human, Double-Masked, Placebo-Controlled, Dose-Escalation Study Evaluating the Safety, Tolerability, and Efficacy of RU-101 Ophthalmic Solution in Patients with Severe Dry Eye. Sponsor Protocol No. RU-101-C001. WIRB Protocol No. 20131219
Davidson, Richard13-2241
A Multicenter, Open-Label, Extension Study to Evaluate the Long-Term Safety and Efficacy of BIIB019, Daclizumab High Yield Process (DAC HYP), Monotherapy in Subjects With Multiple Sclerosis Who Have Completed Study 205MS301. Sponsor Protocol No. 205MS303. WIRB Protocol No. 20131532
Miravalle, Augusto13-2243
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING, MULTICENTER STUDY TO ASSESS THE EFFICACY AND SAFETY OF RIFAXIMIN SOLUBLE SOLID DISPERSION (SSD) TABLETS FOR THE PREVENTION OF COMPLICATIONS IN SUBJECTS WITH EARLY DECOMPENSATED LIVER CIRRHOSIS. Sponsor Protocol No. RNLC2131. WIRB Protocol No. 20131309
Forman, Lisa13-2245
A Follow-up Study to Assess Resistance and Durability of Response to AbbVie Direct-Acting Antiviral Agent (DAA) Therapy in Subjects Who Participated in Phase 2 or 3 Clinical Studies for the Treatment of Chronic Hepatitis C Virus (HCV) Infection. Sponsor Protocol No. M13-102. WIRB Protocol No. 20131190
Everson, Greg13-2249
A Multicenter, Open-label BMN 110 US Expanded Access Program (BMN 110 US EAP) to Provide BMN 110 to Patients Diagnosed with MPS IVA. Sponsor Protocol No. 110-503. WIRB Protocol No. 20130460
Thomas, Janet13-2262
Clinical Outcomes Assessment of the MitraClip Percutaneous Therapy for Extremely High Surgical Risk Patients (The COAPT Trial). Sponsor Protocol No. 11-512. WIRB Protocol No. 20120840
Brieke, Andreas13-2266
A Phase 2, Multicenter, Open-Label STudy to Investigate the Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose Combination + Ribavirin Administered in Subjects Infected with Chronic HCV who have Advanced Liver Disease or are Post-Liver Transplant. Sponsor Protocol No. GS-US-337-0123. WIRB Protocol No. 20131329
Everson, Greg13-2272
A multicenter, randomized, double-blind, parallel-group, placebo-controlled variable treatment duration study evaluating the efficacy and safety of Siponimod (BAF312) in patients with secondary progressive multiple sclerosis. Sponsor Protocol No. CBAF312A2304. WIRB Protocol No. 20130508
Corboy, John13-2286
AN OPEN-LABEL, MULTICENTER, FOLLOW-UP STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF BRIVARACETAM USED AS ADJUNCTIVE TREATMENT IN SUBJECTS AGED 16 YEARS OR OLDER WITH EPILEPSY. Sponsor Protocol No. 2010-020345-27. WIRB Protocol No. 20101907
Strom, Laura13-2308