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Clinical Trials

Volunteer to be part of a research study


Researchers at the University of Colorado School of Medicine conduct hundreds of clinical trials and studies each year to help find ways to cure disease and improve quality of life. Some trials investigate the use of drugs, devices or therapies. Others emphasize behavioral changes.

All research projects comply with the Colorado Multiple Institutional Review Board (COMIRB) to ensure that federal, state and institutional policies are followed. This ensures that participants will be protected and treated ethically and with dignity, as well as safeguarding study outcomes.

If you would like to participate in a study, click on the Who Can Participate category for details.

If you are a researcher seeking volunteers and your study is not posted here, please email the Research Affairs office. These postings will be deleted two months after their announcement unless we are otherwise notified.

 

​Who Can Participate ​Goal of the Study ​Posted
​​Healthy, overweight women 25-40 with a BMI between 27-35 and skip breakfast on a regular basis (>5X a week) ​​To learn more about the health effects of skipping breakfast. ​6/18/13
Highly motivated women 18-35 who are 10-14 weeks pregnant with single fetus normal or overweight
and willing to complete 5 visits during pregnancy
​​
​​To learn how a mother's metabolism is connected to her baby's. ​6/18/13
​​Mothers of infants 9-24 months that is breastfed or has not received formula in 3 months, not iron deficient ​​To screen for iron deficiency and find ways to improve treatment. ​6/18/13
​​People who have had type 2 diabetes less than five years and only take Metformin​ ​To evaluate the relative long-term metabolic and clinical effects of four classes of drugs in combination with Metformin for the treatment of Type 2 diabetes​. ​6/18/13
Children 7-18 have been diagnosed w/schizophrenia, schizoaffective disorder or have been diagnosed w/ADHD or no psychiatric history​​​ ​To measure the structural and functional brain differences between children who have Schizophrenia or Bipolar Disorder and those w/no history of mental illness.​ ​6/18/13
​​Children 8-17 ​​To test 2 medicines for migraine prevention in children and teens. ​6/18/13
​​People with celiac disease ​​To test a new survey system while eating food with or without a small amount of gluten.​ ​6/17/13
​​Persons 45-70 (women must be post-menopausal) w/Type 2 Diabetes, non-smoking, exercise less than 1 hour a week and BMI of less than 35 ​​To test 3 months of treatment with Exenatide or a placebo to control Type 2 Diabetes.​ ​6/17/13
Pregnant women with 23 weeks or less of gestation and who are planning to deliver at University of Colorado Hospital ​​The goal of Healthy Start is to understand what factors during pregnancy and early life influence a child's healthy growth and risk for obesity and future diseases.​ ​6/17/13
Persons 45 or older who are non-smokers and have been diagnosed with COPD, Emphysema, or Chronic Bronchitis ​​Study participation involves pulmonary function testing, blood draw, possible bronchoscopy, and free study medication (Spiriva) provided​.​ ​6/17/13
People between 45-89 w/Parkinson's Disease on stable doses of medications and healthy controls. No metal in the body​​​ ​To study the use of simultaneous brain scans and memory tasks to see if stimulating certain areas of the brain improves thinking and memory.​ ​6/17/13
Persons 19-65 w/BMI of between 25-45 and start the day by 9a.m. at least 5 days a week​​ ​To compare the effectiveness of different dietary recommendations on weight status.​ ​6/17/13
Healthy, participants 9-18 w/no history of seizures, seizure like episodes, neurological diseases or a loss of consciousness greater than 5 minutes in their immediate family ​​To examine how children with epilepsy compare to healthy children in areas such as behavior, neuropsychological skills and quality of life. ​6/10/13
Youth with a family history of bipolar disorder​​ ​To help youth and their families understand and cope with mood swings, develop plans for preventing moods from getting worse, communicate more effectively and solve family problems.​ ​6/5/13
Persons 18+ with Type 2 Diabetes, and take no more than 3 diabetes medications (click here for more details) ​To look at the use of an extended release formula of Exenatide compared to a placebo to maintain normal glucose levels. Ultimately to see better control of diabetes and a decrease in cardiovascular disease events.​ ​6/5/13
Persons 30-60 who have Type 2 Diabetes, normal blood pressure, have not smoked for at least a year, and have a BMI 25-39.9 ​To research the effects of an investigational drug on
exercise capacity and blood vessel function​.​
​6/5/13
Persons 40 and over who have Parkinson's Disease, are stable on medications for at least 30 days, not experiencing dementia, and who are highly fatigued​​ ​Determine the effect of acupuncture on fatigue, mood, motor severity and quality of life with Parkinson's 
Disease.​
​6/5/13
Persons 18+ currently a medical marijuana patient using medical or non-medical marijuana ​To learn more about the medical marijuana industry in Colorado and its relationship to health risk behaviors and healthcare. ​6/5/13
Children 10-17 of normal weight and no medical issues​​​ ​​To learn if obstructive sleep apnea and low oxygen levels have a role in developing Non-Alcoholic Fatty Liver Disease (NAFLD).​​​ ​6/5/13
Persons 21+ who have trouble falling or staying asleep ​​Study the effects of two different study drugs, one or two non-drug interventions and/or a combination of both to treat insomnia.​ ​6/4/13
​​Persons 40-80 have been diagnosed with Parkinson's Disease but have not begun taking medication and do not plan to start within the next 6 months ​To explore the effects of different doses of endurance exercise for people who have Parkinson's Disease.​ ​6/4/13
Persons under age 21 w/Type 2 Diabetes ​​Build the largest Type 2 Diabetes registry in the country.​ ​6/4/13
​​Adolescents 13-18 w/out serious medical conditions, who have been diagnosed w/either anxiety disorder or cyclical vomiting​​​ ​To learn more about risk factors for anxiety in adolescents with cyclic vomiting syndrome. ​6/4/13
Persons 3-80 who have atopic dermatitis or 8 months to 80 years who have a history of or an active case of eczema herpeticum​​​ ​This is a study on eczema​.​ 6/4/13​
Persons 18+ diagnosed w/asthma, non-smoking, currently on inhaled steroid or other daily controller medication. Willing to undergo bronchopscopy ​​Test pulmonary function.​ ​6/4/13
​Persons 21-65, non-smoking, non-diabetic, exercise no more than
1 time per week while maintaining 
current weight for at least 6 months, BMI between 30-40
​To learn more about how exercise helps people keep weight off after losing weight with a diet only intervention. ​6/3/13
Persons 18+ healthy with plantar warts on the feet, who are not pregnant, have no history of kidney disease and no reaction to Drysol​​​ ​To evaluate whether treatment of sweating on the feet improves the efficacy of standard therapy for plantar warts (warts on the feet).​​​ ​6/3/13
Women 40-52 who have regular periods and any of the following: hot flashes, cyclical bloating, mood change, headache, and/or trouble sleeping ​​To study the effects of medication on perimenopausal symptoms.​ ​6/3/13
People between 18-30 or 65-80 years of age, must be right handed, have no significant prior head injury or medical, neurological or psychiatric disease ​To investigate how cognitive fatigue impacts quality of life and activity levels in healthy older adults. ​6/3/13
​​Volunteers with moderate Chronic Kidney Disease (CKD) 18+ years of age ​​To understand the effect of lowering serum uric acid levels on vascular function in individuals with CKD by comparing Allopurinol therapy and a placebo.​ ​6/3/13
​​Adolescents between 12-17 w/at least 15 headaches a month for 6 months. No previous BOTOX treatments and no prophylactic medication ​To evaluate the efficacy and safety of a single treatment cycle with 2 dosages of intra-muscular (IM) injected BOTOX in adolescents with chronic migraine. ​6/3/13
Persons w/Down Syndrome between 19-30 years of age​​​ ​​To examine visual brain function in people with mild memory impairments to detect early signs of Alzheimer's Disease.​ ​5/30/13
​​Healthy female adolescents 11-17, not obese, and with no serious medical conditions, are right-handed and have no metal in their bodies ​​To examine brain imaging research to study how the brain works when we taste sweets or receive money. ​5/30/13
Children ages 1-20 diagnosed w/Multiple Sclerosis (MS)  before age 19 and healthy controls w/out MS ​To learn more about Multiple Schlerosis among the pediatric population. ​5/30/13
Asthmatics 12+, non-smoking and asthma is well controlled​​ ​​A comparison study of previously approved FDA medications for asthma. ​5/29/13
​​Persons 18-80 who have chronic kidney disease stage 3B or 4, have vitamin D deficiency/insufficiency, and women must not be pregnant or breastfeeding ​This study will examine whether nutritional or active
vitamin D supplementation will improve blood vessel
function​.
​5/29/13
Asthmatics 15-60, not current smokers​​ ​To see if the CPAP helps asthmatics breathe better. ​5/29/13
Persons 50-70 who exercise less than 1 hour a week, have normal blood pressure, w/BMI of between 25-35 and have not smoked in a year ​​To learn more about how different levels of exercise feel to people w/Type 2 Diabetes and those without. ​5/29/13
Persons +18 needed for Type 2 Diabetes Research ​This is a long-term outcomes study for a diabetes drug. ​5/28/13
Healthy normal weight girl 10-15 who have not started their menstrual cycle, is not taking hormones, does not exercise more than 4 hours a week ​To investigate the changes a young girl's body goes through prior to menstruation. ​5/28/13
Healthy persons between 30-55, w/ and w/out Type 2 Diabetes (not using insulin), non-smoking, currently exercise no more than once per week, and BMI less than 32 ​To evaluate exercise function during single leg calf exercise in people w/ and w/out type 2 diabetes.​ ​5/28/13
Persons +50​ w/Type 2 Diabetes or Heart Disease able to attend clinic for 3 years ​To test new medication for Type 2 Diabetes.​ ​5/28/13
Persons 18+ diagnosed w/asthma that is well controlled by daily medication, non-smoking and seasonal allergies ​To test pulmonary function with study medications.​ ​5/28/13
Overweight persons taking oral medication for Type 2 Diabetes​​​ ​To evaluate an investigational non-surgical medical device for the treatment of Type 2 Diabetes.​ ​5/28/13
Women who are pregnant or nursing willing to donate a one time breast biopsy, blood and urine samples and have not been diagnosed w/breast cancer or immune disease​​ ​To collect breast tissue of healthy women to use in a comparison study of women with breast cancer.​ ​5/24/13
Women 18-40 diagnosed w/poly cystic ovary syndrome and not pregnant ​​To examine health related quality of life issues and coping strategies in women w/polycystic ovary syndrome. ​5/23/13
Persons 30-60 who are lean - have a BMI below 25​​​ ​Investigate how fat stored in your muscle affects
insulin activity​.
​5/23/13
Persons 30-60 who are overweight - have a BMI above 30​​​ ​Investigate how fat stored in your muscle affects
insulin activity​.​
​5/23/13
Adolescents w/Type I diabetes, ages 12-19 and BMI percentage between 5-100 ​To determine the effects of Metformin on Cardiovascular Function in Adolescents with Type 1 Diabetes. ​5/22/13
Persons 25-50 w/Type 1 diabetes, normal blood pressure and exercise less than 4 times per week ​To understand how taking Metformin effects the
vasculature and mitochondrial function of people w/Type 1 diabetes.
​5/22/13
Healthy boys 11-13 and girls ages 9-11​​​ ​To study changes in blood sugar during puberty. ​5/22/13
Persons 40+ with leg pain that goes away with rest​​​ ​To examine the effects of exercise training for treating people with peripheral artery disease.​ ​5/21/13
Pregnant women, at least 28 weeks, age 20-35 who are planning to exclusively breastfeed and deliver at University of Colorado Hospital​​​ ​To find out how maternal size and diabetes status affect women's breast milk.​ ​5/21/13
Healthy non-smoking women 18-49 who have regular menstrual cycles and are not currently using hormonal contraceptives ​We are looking for healthy young women to participate in a research study on Prevention of Obesity in Women via Estradiol Regulation (POWER)​. ​5/20/13
Non-smoking postmenopausal women 45-70 who went through menopause within the past 6 years or are more than 10 years past menopause (Click here for more details) ​To test whether estrogen has different effects on
blood sugar early in menopause compared to many
years after menopause​.​
​5/20/13
Non-smoking adults w/persistent asthma who have not taken inhaled steroid medication in the past 30 days ​Learn biofeedback, to take charge of asthma. ​5/17/13
Women 18-39 w/a BMI greater than 30, normal menstrual cycles, not currently using hormones and not pregnant or trying to conceive ​To examine how BMI affects fertility.​ ​5/15/13
Persons 25-50 who have Type I Diabetes, exercise no greater than 3X a week and normal blood pressure; normal controls needed as well​ ​To learn more about the function of the body's blood vessels and muscles and the body's ability to use insulin while taking a drug called Acipimox. ​5/15/13
Children 6-17 with skin rashes or allergies and those diagnosed contact dermatitis ​To test seven new antigens on the child and adolescent population to add to the current standard test.​ ​5/15/13
Women between the ages of 50-65 who experience hot flashes as a part of menopause ​To examine non-hormonal treatment for relief of hot flashes in menopausal women.​ ​5/14/13
Healthy persons 18+ with no history of neck pain who work at least 30 hours a week and within 3 months of hire at current job ​To identify risk factors for the development of chronic neck pain in healthy office workers.​ ​5/14/13
Persons between 35-55, smokers preferred or those who have recently quit, no history of alcohol or drug abuse, no chronic medical conditions ​To examine the effects of heavy alcohol drinking, with and without smoking, on the development of pneumonia and serious pulmonary disease.​ ​5/10/13
Women who are 36 or < weeks pregnant with a single baby, planning to deliver vaginally at University of Colorado Hospital ​To use and understand the STAN monitor during labor and delivery. ​5/10/13
Men age 62 or older, who have at least 12 years of education and no neurological disorders ​The purpose of this study is to study the effects of the Fragile X Tremor-Ataxia Syndrome (FXTAS) on mental abilities and brain function.​ ​5/10/13
Children ages 6-12 healthy, with no major psychological or medical illness and who take no medication ​To examine the movement and behavior patterns of children and adolescents who are healthy compared to children and adolescents with ADHD.​ ​5/9/13
Children ages 6-12 who have been diagnosed with ADHD, without serious medical conditions ​To examine the movement and behavior patterns of children and adolescents who are healthy compared to children and adolescents with ADHD.​ ​5/9/13
Healthy women 18-35 thinking about using long term, reversible birth control Study the effects of an investigational intrauterine system (IUS).​​​ 5/1/13​
Persons 18-55 w/and w/out a history of low back pain​ To investigate the basic science of spinal manipulation.​ 4/25/13​
Adolescents 13-17 who have no serious medical conditions and have 2-15 headaches per month​​​ This study will provide supplementary and/or additional treatments for children's headaches​.​ 4/24/13​
Healthy women 42-52, that have regular menstrual cycles, not currently using hormonal contraceptives​​ To examine the role that female sex hormones play in metabolism, energy expenditure, physical activity and chronic disease.​ 4/23/13​
Persons 18-65 with shoulder pain and able to come to physical therapy 8 times in a 30-day period To compare the effects of exercise versus exercise plus manual therapy to the neck and upper back on shoulder pain.​ 4/19/13​
Women 50-69 never told you have breast cancer, English speaking, non-Hispanic, have not had a mammogram in the last 2 years​​ To learn more about reasons some women do not have a yearly mammogram.​ 4/15/13​
Adult females 18-45 right-handed, free of medication, healthy weight, no series medical conditions and no permanent metal in your body​ To learn more about treatments and preventative measures for anorexia and bulimia.​ 4/10/13​
Healthy women 18+ willing to make a one time blood donation and have not been diagnosed w/an immune disease such as diabetes, hepatitis or rheumatoid arthritis Compare immune systems of healthy individuals to those with cancer.​ 4/9/13​
Healthy men 18+ willing to make a one time blood donation and have not been diagnosed w/an immune disease such as diabetes, hepatitis or rheumatoid arthritis Compare immune systems of healthy individuals to those with cancer.​ 4/9/13​
Healthy persons 30-45, have a BMI between 30-40 and willing to take Phentermine for 8 weeks To learn more about if hunger sensation, or the desire to eat food, predicts whether or not individuals respond to the drug Phentermine.​ 4/9/13​