|We are looking for Healthy Women to participate in a research study on.....Females, Aging, Metabolism, and Exercise (FAME)|
To examine the role that female sex hormones play in metabolism, energy expenditure, physical activity and chronic disease.
Healthy women 40-60 who have regular menstrual cycles and using no hormonal contraceptives
|Do you have Diabetes?|
To find the best combination drug treatment for type 2 diabetes
Persons who have had diabetes for less than 5 years and metformin is the only diabetes medication you are taking.
|Type 1 Diabetes Research Study|
To study the effects of an FDA-approved medication on metabolism and blood vessel function.
Person 25-50 with type 1 diabetes who exercise vigorously less than four times per week and have normal blood pressure
|Just received VARIVAX, the chickenpox vaccine?|
Research study looking at the immune response to chickenpox vaccine
Age 12 months to 50 years; able to enroll in study within 10 days of vaccination.
|Healthy Hispanic Female Needed|
For brain imaging research study on how the brain works with we taste sweets. Your participation could help us to develop treatments and preventive measures for anorexia nervosa and obesity
Healthy females 22 to 29 who are right-handed, free of medication with no serious medical conditions, permanent metal implants or braces/retainers, and are at a healthy body weight.
|Looking for HIV-positive individuals to participate in a research study on Lipodystrophy Syndrome|
We are conducting a study of the relationship of bacteria in the gut to HIV
infection. We are interested in finding out whether people who have
metabolic diseases such as lipodystrophy (loss of fat tissue) as complications of
long term antiretroviral therapy have a different makeup of their gut bacteria.
We are therefore seeking volunteers with HIV infection to participate in a study
of bacteria in the stool.
-Non-obese HIV positive individuals who are 18-65 years old
-Either not currently on antiretroviral therapy (ART naïve or off therapy for 6
months or greater) or on effective ART with documented suppression for 6
months or greater.
-We are particularly interested in enrolling subjects with lipodystrophy, but
would also like to enroll individuals without lipodystrophy as controls.
|Looking for HIV-positive and HIV-negative men to participate in a research study on smoking and lung disease|
We are conducting a study to look at lung complications and disease in
-Between 30 and 70 years old
-Both HIV-positive and HIV-negative individuals with and without chronic
obstructive pulmonary disease (COPD)
-If HIV-positive, on a stable three-drug ART regimen with undetectable viral
load for past 6 months
The GENETIC-AF is a trial that will investigate the safety and effectiveness of an investigational drug on the recurrence of symptomatic atrial fibrillation in people who have heart failure. The investigational drug will be studied versus an approved drug after patients receive an electrical cardioversion.
Adults who have symptomatic atrial fibrillation may be eligible.
|2/22/2017||Heart and Blood Diseases
|Healthy Volunteers Needed|
To examine the differences in two subtypes of Parkinson Disease compared to health controls. This study involves an MRI.
- Between the ages of 50-80
- No metal in your body
- In general good health
|2/22/2017||Nervous System Diseases
|Information for patients. Living with diabetes is complicated.|
The FREEDOM-3S Study is a clinical research study that will involve approximately 126 patients in the United States. It will look at a potential new treatment option, the ITCA 650,for people with type 2 diabetes. The ITCA 650 is a small metal cylinder (about the size of a matchstick) that is placed under the skin of the abdomen (belly) to slowly release the study medication – exenatide. The FREEDOM-3S Study is looking at how safe and well tolerated two different doses of the ITCA 650 are in people with type 2 diabetes who are already taking liraglutide (also known as Victoza injections, and metformin.
You may be eligible to take part if you:
• are 18–80 years of age
• have been diagnosed with type 2 diabetes for at least 3 months
• have been taking liraglutide (Victoza) injections and metformin every day for at least 3 months.
|2/22/2017||Gland and Hormone Related Diseases
|Controlling blood glucose levels. Can be a real balancing act.|
The EASE-3 clinical research study is a study in which doctors hope to learn:
• Whether the investigational medicine is safe to use in treating type 1 diabetes.
• Whether adding the investigational medicine is more effective in controlling blood glucose than insulin alone.
You may be able to join this study if you:
• Are 18 years of age or older and you have had insulin-dependent type 1 diabetes for at least a year.
• Are willing to take a study medicine in addition to your insulin therapy.
• Have an HbA1c level that falls within the range required by the study.
• Have a good understanding of your disease and the ability to manage it and are willing to undergo study assessments.
|2/22/2017||Gland and Hormone Related Diseases
|Do you have headaches?|
The University of Colorado is participating in a research study to determine if thoracic spine thrust manipulation alone is beneficial in the treatment of cervicogenic headaches. This project will see if this treatment can aid in reducing pain from these headaches.
You may be eligible to participate in this study if you answer yes to the following questions:
- Do you have headaches that are mostly on one side which are associated with neck pain?
- Are these headaches worse with movement or certain neck positions?
- Do you have these headaches at least once a week for at least the last 2 months?
- Are you between 18-60 years of age?
- Can you come to physical therapy up to 6 times within a 30 day period?
You may be ineligible to participate in this study if you have:
- Rheumatoid arthritis
- Broken bones in your neck or shoulder
- A prolonged history of steroid use
- A history of whiplash injury within the past six weeks
|2/22/2017||Muscle, Bone, and Cartilage Diseases
|Rotator Cuff Clinical Research Study|
The InSpace device is a balloon shaped implant made from a polymer, which is widely used material in the medical industry. The material is biodegradable meaning that following surgery it will gradually dissolve until it is completely absorbed at approximately one year following the implantation. During this time, the device is intended to support your shoulder healing allowing frictionless gliding between the shoulder bones which may improve shoulder muscle activity.
In order to participate, you must:
Be 40 years of age or over and in general good health.
Experiencing persisting shoulder pain for at least four (4) months which failed non-operative treatments such as:
• Physical therapy
• Activity modification
• Rest (sling)
• Anti-inflammatory medication
Have had an MRI within 9 months that confirms a full thickness rotator cuff tear.
Fulfill all study criteria as assessed by your surgeon and be willing to return for all follow-up visits.
|2/22/2017||--Select a Category--
|EFFECTS OF TESTOSTERONE THERAPY IN YOUNG ADOLESCENTS WITH KLINEFELTER SNDROME (47.XXY)|
This study will study the effects of testosterone therapy on behavior, mood, problem solving, attention span, and motor skills in adolescent males with Klinefelter syndrome in early puberty. During this period in early puberty there is a lot of variability in how and when doctors start testosterone therapy. This study will evaluate if there are benefits to starting testosterone therapy in early puberty.
Participants with Klinefelter syndrome in early puberty (around age 10-15).
|MS Volunteers Needed for Research Study|
Looking to see if there is a cognitive improvement with the treatment of oral estriol as compared to oral placebo
We are looking for: • Women 18-50 years old • Diagnosed with definite relapsing-remitting, secondary-progressive multiple sclerosis or primary-progressive multiple sclerosis • MS disease duration of 15 years or less • On stable dose of standard MS treatment with Copaxone®, Betaseron® (or Extavia®), Rebif®,Avonex®, Gilenya®, Aubagio®, Tecfidera®, or no treatment ----You are not eligible for the study if you are pregnant, breast-feeding, smoke, or have other serious medical conditions.
|Volunteers with Alzheimer’s Disease Needed for Memory Study|
To examine the safety and efficacy of the study drug, Sargramostim (Leukine®), on memory in adults with Mild-to-Moderate Alzheimer’s Disease.
1. Age 55 to 85 years;
2. Should have a mild-to-moderate Alzheimer's Disease diagnosis (Mini-Mental State Examination 10-26 inclusive);
3. If on anti-dementia treatment should be on stable treatment for at least 2 months (i.e. cholinesterase inhibitor and/or Memantine or Axona);
4. Stable on all other medications for at least 30 days prior to screen;
5. Should be fluent in English;
6. Should be physically able to participate by medical history, clinical exam and tests;
7. Should have a study partner to accompany them to scheduled visits.
|T•A•C•I•T - Therapy After Cochlear Implants Using Telemedicine |
This research plans to learn more about the use of telemedicine as a means of providing therapy to children who have a cochlear implant(s). While Auditory-Verbal Therapy has typically been delivered in person, many people are starting to access therapy over the internet. We are conducting this research to determine if the outcomes of therapy are the same when AVT is delivered in person and via telemedicine.
The T•A•C•I•T team is looking for children ages 6 mos.-6 yrs. old who were implanted with cochlear implant(s) before age 3 ½.. Each child will spend nine months in both the in-person and telemedicine condition. The therapist will remain the same throughout the study. Total participation will last 18 months. The child will be tested three times: once when the study starts, and every nine months after that. A qualified study team member will administer speech, listening, and language tests to the child. They will also receive tests to identify how well their auditory area of the brain is developing.
|Participants with Chronic Kidney Disease Needed for a Research Study about Phosphate|
We are looking for men and women to participate in a research study examining whether
lowering blood levels of phosphate will improve blood vessel function.
We need men and women who:
-are age 40-79 years old; women must be post-menopausal;
-have chronic kidney disease stage 3b or 4 (estimated GFR 15-45 ml/min);
-are not taking phosphate binders;
-do not have high blood phosphate (>5.5 mg/dL).
|Volunteers Needed for Cardiovascular Research Study at the Division of Renal Diseases and Hypertension Clinical Research Unit|
This research study will compare blood vessel function in healthy adults to adults with two different types of kidney disease. The testing visit will include non-invasive testing of blood vessel function and collection of blood and cells from an IV. As a volunteer, you will receive the following information about your health: resting EKG; blood cholesterol screening, blood sugar screening, blood pressure screening, and physical Exam.
We are looking for men and women, aged 18-80 years, non-smokers, generally healthy, and free from hypertension. Women must not be pregnant of trying to become pregnant
|2/21/2017||--Select a Category--
|Do you have insomnia or Use cannabis to help you sleep?|
We are interested in learning more about the effects of cannabis use for insomnia and how it may or may not affect your sleep
Adults 21-80 years old
cannabis use for sleep
|2/21/2017||--Select a Category--
|Healthy Women Needed|
This study plans to research how metabolic challenges of increased insulin and increased fats affect reproductive hormones.
In order to be eligible you must: Be a healthy woman age 18-38, have a BMI between 18 and 25, have regular menstrual cycles (25-35 days), not be currently using hormones (like birth control medication), not be pregnant or planning to become pregnant. In order to enroll all participants must meet specific criteria. The criteria listed above is only a partial list of all the requirements. Only a clinical research staff member can determine eligibility.
|2/21/2017||--Select a Category--
|Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease?|
This study plans to learn more about the effect of palliative care on patients and caregivers affected by Parkinson’s disease or related disorders including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA) or Lewy Body Dementia (LBD). Palliative care is a treatment approach focused on improving quality of life by relieving suffering in the areas of physical symptoms such as pain, psychiatric symptoms such as depression, psychosocial issues and spiritual needs.
Over the age of 40 and have been diagnosed with Parkinson's disease (PD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), or Lewy Body Dementia (LBD); and have unmet needs, such as poorly controlled non-motor symptoms, psychological issues, spiritual challenges or caregiver distress.
|2/21/2017||Nervous System Diseases
|Volunteers Needed for a Research Study about Rheumatoid Arthritis|
The purpose of this study is to learn more about how rheumatoid arthritis
develops even before the first joint symptoms appear.
You may be able to participate in the study if:
You are at least 18 years old
You do NOT have rheumatoid arthritis (RA)
|2/21/2017||Immune System Diseases
|Heart Sounds at Home: Prospective Maternal Surveillance of SSA Positive Pregnancies using a Hand-held Fetal Heart Rate Monitor|
The purpose of the research study is for pregnant SSA positive mothers, using a home Doppler fetal heart rate monitor, to detect abnormal heart rates and rhythms in their babies before they are both
Exclusion criteria are:
1. If you are less than 16 weeks or > 18 6/7 th weeks pregnant
2. If you do not have SSA antibodies
|2/21/2017||Diseases and Abnormalities at or before Birth
|CGMA Needs Children and Adults with Cerebral Palsy for a Walking Study|
Looking for children with Cerebral Palsy to participate in research study that will evaluate and develop wearable technologies that quantify human movement.
Cerebral Palsy Group - Inclusion criteria: Clinical diagnosis of cerebral palsy (spastic diplegia or hemiplegia); GMFCS level of I-III; Age Range: 7 - 25 years; Able to walk continuously for 2 minutes; Provide informed consent or assent; Follow directions and otherwise comply with testing instructions. Exclusion criteria: Additional clinical diagnosis other than CP; GMFCS level IV, V; Endurance limitations that would prevent the subject from
completing all trials; Recent surgical or medical interventions that may have altered
their gait at the time of the analysis; Recent injury that alters their gait at the time of analysis.
Control Group - Inclusion criteria: Age and gender matched to Cerebral Palsy participant; No diagnosis of Cerebral Palsy; Typical development and typical gait. Exclusion criteria:
Neuromuscular diagnosis or other condition affecting walking ability; Recent surgical or medical interventions that may have altered their gait at the time of the analysis; Recent injury that alters their gait at the time of analysis.
|2/21/2017||Nervous System Diseases
|Smokers Wanted for Brain Research Study|
We want to know if magnetic stimulation of the brain can reduce cigarette cravings. We will do an MRI of your brain before and after the magnetic stimulation. This study takes 3 hours of your time in one single visit.
We want to know if transcranial magnetic stimulation of the brain can reduce cigarette cravings. We will do an MRI of your brain before and after the magnetic stimulation. This study takes 3 hours of your time in one single visit. This study is funded by the NIH (F32 DA 041011).
You may qualify if you:
• Smoke at least 10 cigarettes per day (on average)
• Are 18-55 years old
• Have no metal implants
• Have no history of seizures
• Are able to not smoke for 3 hours
|2/21/2017||Behaviors and Mental Disorders
|Are you interested in learning about how your breast milk helps your baby grow?|
To find out how maternal size and diabetes status affect her breast milk
To find out what unique parts of breast milk may affect how infants grow.
To learn how to ensure infants receive the best nutrition possible
Women 20-35 who are at least 28 weeks into their pregnancy and planning on exclusively breastfeeding their infant for at least 4 months and delivering at University of Colorado Hospital.
|Free Family Therapy for Youth with Mood Problems|
Helping youth and their families understand and cope with mood swings, develop plans for preventing moods from getting worse, communicate more effectively and solve family problems
- Youth between 9-17 who has recently had significant mood swings, has at least one parent with bipolar disorder and does not abuse alcohol or substances.
- Must agree not to participate in family therapy with another provider for the first year.
This study will look at the body's immune response (how the body fights infection) to the onset of genital herpes. 1-2 study visits for blood draws over the course of 3 months.
- 18+ years of age
- Have developed an outbreak of genital herpes within the last 10 days.
|Healthy Males needed for a research study of drug levels in blood and hair.|
This study plans to learn more about how tenofovir and emtricitabine (Truvada) build up in cells in blood and hair. Participation will include two 12 week dosing periods separated by a 12 week washout period (total duration is 36 weeks). Eligible participants will be given the supply of medications for the study.
- Must be age 18 to 50 years
- Must own smartphone
- Subject has a minimum scalp hair length of 2 cm in the occipital region.
- Have a low risk for HIV-1 infection