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Neuroscience Program Faculty


Areas of Research

Developmental Neuroscience
Down’s Syndrome and Alzheimer’s Research
Epilepsy
Fly Research Group
Ion Channels and Biophysics
Motor and Cognitive Disorders
Neurobiology of Stroke
Neuroendocrinology
Neuroengineering
Neuroimmunology
Neuropharmacology
Neurovirology
Optogenetics
Other Developmental Disorders
Psychiatric Disorders & Functional Imaging
Sensory Systems
Synaptic Signaling and Plasticity
Systems
Show All
Faculty
Aviva  Abosch
Medicine
We are interested in understanding neural circuits in movement disorders, epilepsy, and the neuropsychiatric disorders. We use intraoperative and extra-operative neurophysiological recordings and stimulation, in addition to functional imaging, in human subjects to look for biomarkers of disease that will inform the next generation of therapeutics.
Jason  Aoto
Pharmacology
The Aoto Lab is interested in dissecting the distinct functions of synaptic cell-adhesion molecules implicated in neuropsychiatric disorders, neurodevelopmental disorders and addiction. We are interested in dissecting the role of these essential molecules by using in vitro (primary neuron cultures, induced pluripotent stem cell (iPSC) derived neurons) and circuit-level in vivo approaches. Using cutting-edge multidisciplinary techniques, we are able to interrogate these molecules with cell-type and synapse-specific resolution.
optogenetics; psychiatric; synaptic;
Bruce  Appel
Pediatrics
Development and repair of the vertebrate nervous system
developmental;
Kristin  Artinger
Craniofacial Biology
Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis
developmental;
Roger  Bannister
Cardiology
Development of therapeutic strategies to slow or even halt the progression of muscle deterioration and motor neuron death in aging and neuromuscular disease (e.g., ALS).
ion; motor;
Linda  Barlow
Cell and Developmental Biology
Developmental neurobiology; patterning and formation of sensory organs
developmental; sensory;
Emily  Bates
Pediatrics
Roles of ion channels in regulating developmental signaling in fruit flies and mice. A second project focuses on the regulation of the actin cytoskeleton in autism
developmental; disorders;
Ulli  Bayer
Pharmacology
Molecular memory mechanisms in cellular signal transduction and neuronal function; CaMKII and Ca2+ signaling
alzheimer; ion; motor; stroke; neuropharmacology; synaptic;
Kurt  Beam
Physiology and Biophysics
Ion channels and calcium signaling in nerve and muscle cells. Excitation-contraction coupling in muscle cells
ion;
Tim  Benke
Pediatrics, Neurology and Pharmacology
Mechanisms of synaptic plasticity, autism, intellectual disability, development and seizures
developmental; epilepsy; ion; neuropharmacology; disorders; synaptic;
Jeff  Bennett
Neurology
Neuro-immunology; mechanisms of neural and glial responses to me neuro-inflammatory disease
neuroimmunology;
Amy  Brooks-Kayal
Pediatrics
Mechanisms of epilepsy; new therapies for prevention and disease modification for epilepsy; regulation of GABA(A) receptors
epilepsy;
Joe  Brzezinski
Ophthalmology
Development of the mammalian retina
developmental; sensory;
John  Caldwell
Cell and Developmental Biology
Functional regulation of ion channels in plasma membranes and Golgi membranes using electrophysiology and molecular biology
ion; neuroengineering; optogenetics;
Mark  Dell
Pharmacology
Organization of signaling complexes by protein kinase and phosphatase anchoring proteins; mechanisms regulating neuronal second messenger signaling in synaptic plasticity.
alzheimer; ion; motor; neuropharmacology; synaptic;
Robert  Eckel
Endocrinology, Metabolism and Diabetes
The role of lipoprotein-derived lipids in regulating energy balance, body weight, insulin action, learning and memory
Gidon  Felsen
Physiology and Biophysics
Neural bases of sensorimotor decision making
motor; neuroengineering; optogenetics; systems;
Tom  Finger
Cell and Developmental Biology
Development and organization of taste and smell.
developmental; sensory; sensory; systems;
Santos  Franco
Pediatrics
Development of neural circuits in the cerebral cortex
developmental;
Guido  Frank
Psychiatry
Neurobiology of Eating Disorders; brain imaging; reward processing; translational research
psychiatric;
Curt  Freed
Clinical Pharmacology and Toxicology
The dynamic role of dopamine in movement; neural transplantation for Parkinson’s disease
motor;
Robert  Freedman
Psychiatry
Central nervous system physiology and pharmacology and its application to clinical psychiatry
Katheleen  Gardiner
Pediatrics
Molecular basis of cognitive deficits in Down syndrome and other intellectual disabilities
alzheimer; motor;
Marco  Gonzalez
Pediatrics
We are interested in finding out what are the molecular events that transform a normal brain into an epileptic one. This process of transformation, also known as epileptogenesis, involves a plethora of molecular, biochemical and structural changes
Paco  Herson
Anesthesiology
Neurodegeneration and neuroplasticity following cerebral ischemia
stroke; neuropharmacology; synaptic;
Ethan  Hughes
Cell and Developmental Biology
Oligodendrocytes and their Precursors in the Adult Central Nervous System
synaptic; motor; optogenetics;
Molly M. Huntsman
Pharmaceutical Sciences
identifying synaptic neurotransmission defects in Fragile X Syndrome (FXS) and pediatric epilepsy
epilepsy; disorders; synaptic;
Matthew  Kennedy
Pharmacology
Molecular mechanisms of activity-triggered synaptic remodeling.
alzheimer; neuroengineering; neuropharmacology; optogenetics; synaptic;
Sue  Kinnamon
Otolaryngology
molecular mechanisms of taste transduction and afferent signaling
sensory;
Achim  Klug
Physiology and Biophysics
Cellular and systems neurobiology approaches in combination with optogenetics to study the mammalian sound localization pathway and the role it plays in helping us function in a crowded bar on a Friday night.
neuroengineering; optogenetics; sensory; systems;
Benzi  Kluger
Nuerology
Neuroimaging and noninvasive brain stimulation for clinical research of non-motor symptoms in Parkinson's disease
motor;
T. Rajendra  Kumar
Department of Obstetrics and Gynecology
neuroendocrinology;
Tatiana  Kutateladze
Pharmacology
Biochemistry and structural biology, NMR and crystal structures of proteins implicated in cancer, structure based drug design
ion;
Psychiatry and Cell and Developmental Biology
Neuromolecular, cellular and genetic basis of schizophrenia and other neurodevelopmental disorders
Rock  Levinson
Physiology and Biophysics
Dan  Linseman
Biological Sciences
Wendy  Macklin
Cell and Developmental Biology
Oligodendrocyte Differentiation and Myelination in the Central Nervous System
developmental; motor;
Anna  Malykhina
Surgery
Neural mechanisms of pelvic organ cross-sensitization, neurogenic bladder dysfunction in neurological disorders, mechanosensitivity and mechanotransduction in the human detrusor, effects of partial bladder obstruction on bladder development and function, stretch-activated and voltage-gated ion channels in visceral smooth muscle, altered contractility of the detrusor muscle in diabetes, role of pro-inflammatory neuropeptides in the development of neurogenic inflammation in the pelvis and neuropathic pain, and modulation of pelvic pain by ovarian hormones.
ion; sensory;
Manisha  Patel
Pharmacuetical Sciences
Oxidative stress and mitochondrial dysfunction in neuronal disorders
epilepsy; motor; neuropharmacology;
Anthony  Peng
Physiology and Biophysics
We study the molecular mechanisms of the mechanotransduction process in the auditory and vestibular system. We use patch clamp electrophysiology paired with mechanical stimulation and high-speed video recordings.
sensory; ion
Anne-Laure  Perraud
Immunology
Calcium signaling, ion homeostasis regulation, and ion channel function in the immune system
Abigail  Person
Physiology and Biophysics
Cerebellar circuit physiology and function
motor; optogenetics; systems;
Huntington  Potter
Neurology
Translational research in neurodegenerative diseases and Down syndrome, especially the roles of inflammation and cell cycle defects
alzheimer; motor;
Cathy  Proenza
Physiology and Biophysics
Molecular physiology of cardiac pacemaking. HCN ion channel biophysics. Intracellular cAMP signaling microdomains. Autonomic nervous system innervation of the heart.
ion;
Subbiah  Pugazhenthi
Endocrinology, Metabolism and Diabetes
alzheimer;
Nidia  Quillinan
Anesthesiology
The Quillinan Lab uses animal models of cerebral ischemia to examine mechanisms of injury and repair in the cerebellum. We use a combination of electrophysiology, neurobehavior and histology to identify targets for neuroprotective and neuro-restorative strategies to improve motor and cognitive function after cerebellar ischemia.
synaptic; stroke;
Yogendra  Raol
Pediatrics
My laboratory focuses on studying changes in the brain following injury to the brain caused by seizures, neonatal hypoxia-ischemia, and trauma, and identifying a treatment that can prevent or reverse these changes and improve neurologic outcome. We use a wide variety of methods, including video-EEG monitoring, MRI, immunohistochemistry, western blotting and behavioral tests to investigate these effects.
Tania  Reis
Cell Biology, Stem Cells and Development
Genetic and Neuronal Basis of Obesity
fly; disorders; systems;
Katie  Rennie
Otolaryngology
vestibular hair cell function
sensory; synaptic; systems;
Diego  Restrepo
Cell and Developmental Biology
Olfactory signal processing in health and disease studied using advanced cellular and systems neurobiology
neuroengineering; optogenetics; sensory; systems;
Angie  Ribera
Physiology and Biophysics
Activity-dependent neuronal development; ion channel expression and function in the embryonic spinal cord
developmental;
Bill  Sather
Pharmacology
Signaling through calcium channels in neurons
ion; neuropharmacology;
Carsten  Schmitz
Immunology
Nathan  Schoppa
Physiology and Biophysics
Mechanisms of olfactory signal processing
ion; optogenetics; sensory; synaptic;
Tamim  Shaikh
Pediatrics
Genetic and Genomic basis of Neurodevelopmental and Neuropsychiatric Disorders
alzheimer; motor; disorders;
Julie  Siegenthaler
Pediatrics
The molecular mechanisms that govern vascular growth and maturation in the developing CNS, specifically the forebrain region (cerebral cortex) and in the retina
developmental;
James  Sikela
Biochemistry and Molecular Genetics
Neurogenomics; human genome evolution and variation; genomic studies of autism and schizophrenia
disorders;
Katharine  Smith
Pharmacology
Molecular mechanisms underlying disrupted Excitatory/Inhibitory (E/I) balance and relevance to neuropsychiatric disease.
neuropharmacology; ion; psychiatric; synaptic; motor; stroke;
John  Swallow
Integrative Biology
Behavioral neuroscience; Animal Behavior; Evolutionary Physiology; Sexual selection
fly;
Matthew  Taylor
Cardiology
Genetic basis of dilated and hypertrophic cardiomyopathies as well as arrhythmogenic right ventricular dysplasia/cardiomyopathy
Slobodan  Todorovic
Anesthesiology
We are interested in deciphering the roles of voltage-gated calcium channels (VGCC) in molecular mechanisms of anesthesia and pain processing. We use sophisticated biophysical techniques to measure membrane currents from acutely dissociated sensory neurons and intact brain and spinal cord slices. We also have cell lines available that express recombinant ion channel proteins which allow studies of the relationship between structure and function. At the system level, we use virally-mediated knockdown and pharmacological blockers to establish the role of various subtypes of VGCCs on pain sensation and anesthetic endpoints using behavioral assays and electroencephalographic (EEG) recordings.
ion; neuropharmacology; sensory;
Dan  Tollin
Physiology and Biophysics
The role of auditory environmental experience, both normal and abnormal, on the development and maintenance of auditory function
developmental; neuroengineering; disorders; sensory; systems;
Richard  Traystman
Pharmacology
Neuroscience, cerebrovascular physiology, stroke, cardiac arrest/CPR, respiration, cardiopulmonary physiology
stroke;
Jason  Tregellas
Psychiatry
Schizophrenia and obesity involving mechanisms of inhibitory dysfunction
Ken  Tyler
Neurology
Molecular and genetic basis for the pathogenesis of viral infections of the CNS
neurovirology;
Sukumar  Vijayaraghavan
Physiology and Biophysics
Brain Cholinergic Signaling
ion; neuropharmacology; optogenetics; sensory; synaptic;
Tim  Vollmer
Neurology
Neuroimmunology, MRI quantitative imaging, Correlations between brain volume loss in MS and Patient Reported Outcomes. Biomarkers in MS
neuroimmunology;
Cristin  Welle
Neurosurgery
neuroengineering; systems; optogenetics; motor;
Maggie  Wierman
Endocrinology, Metabolism and Diabetes
GnRH neuronal migration
developmental; neuroendocrinology;
Wenbo  Zhou
Clinical Pharmacology and Toxicology
Joel  Zylberberg
Physiology and Biophysics
How does the brain represent information about the outside world? How are those representations learned through experience? My lab aims to answer these questions, and to use that knowledge to develop next-generation sensory prosthetic devices
systems; sensory