Mammary gland development and tumorigenesis.
Development and repair of the vertebrate nervous system
Patterning of the early spinal cord (neural plate) during vertebrate embryogenesis.
Cryo-EM of macromolecular machines
Enterovirus RNA replication.
Molecular mechanisms of pediatric disorders
Molecular memory and synaptic plasticity
Eukaryotic mRNA biogenesis
Regulation of genome stability
Regulation of tissue specific gene expression in response to hormonal and growth factor stimuli, characterization of fibroblast growth factor signaling in the pituitary, and the role of protein kinase C in endometrial cancer.
Molecular mechanisms of virus development
Structural biology of gene regulatory mechanisms
Epithelial and endothelial cells in inflammatory bowel disease.
Systemic responses to acute or chronic hypoxia.
Programmed DNA elimination, novel RNAs, and RNA metabolism.
Cancer evolution and dependencies.
Human diseases of the hemostatic system
My lab studies bacterial viruses (known as bacteriophages) and their interactions with their hosts. We aim to understand 1) how intestinal bacteriophages contribute to host-microbe interactions and their overall impact on human health and 2) the molecular mechanisms of bacteriophage infection of multidrug resistant bacteria.
Viral protein/host protein interactions and enzyme motions.
Hematopoietic Stem Cell Development and Maintenance
Regulation of respiratory health and disease by airway mucins
The control of embryonic polarity.
Receptor tyrosine kinase signaling in mammalian craniofacial development
SIX family homeobox genes in development, cell cycle control and tumorigenesis.
Glucocorticoid receptor signaling, inflammatory response, and lung function.
Role of Ets transcription factors in breast cancer.
Regulation of B lymphocyte specific transcription and differentiation
Nucleic acid damage and repair
Complement receptor signal transduction
Role of hypoxic response in tumor progression and metastasis
Function and regulation of the DNA damage response.
Oligodendrocytes and their Precursors in the Adult Central Nervous System.
mRNA surveillance in health and disease
Formation and regulation of chromatin domains and their roles in the nucleus.
Functional genomics, glucose sensing and signaling.
Proteins and nucleic acids structure-function
The characterization and targeting of leukemia stem cells.
RNA structure and plasticity
Structural biology of epigenetics and deciphering the histone code
The ubiquitin proteasome pathway.
Oligodendrocyte Differentiation and Myelination in the Central Nervous System
Differential gene expression during hibernation.
Lactation and Lipid secretion.
Assembly and inheritance of dynamic macromolecular structures
Molecular regulation of the microtubule network in cell division and disease
Systems Biology of Human RNA Regulatory Networks
Skeletal development and variability.
Centriole assembly and function
Inflammation and hematopoiesis
Neurodegenerative diseases and Down Syndrome
Regulation of cell division, cell polarity and cell migration
Nucleosome structure and dynamics in cells
Obesity and Neuronal Control of Energy Balance
Regulation of apoptosis in epithelial cells by signal transduction pathways.
Estrogen and progesterone receptors in breast and gynecological cancers
RNA post-transcriptional, decay and mechanisms of translational regulation.
Functional human pancreatic and thymic cells to understand autoimmune diabetes.
Response and resistance to steroid hormones and anti-estrogen therapies in breast cancer.
Transcriptional networks that regulate pancreas development and differentiation
Spatial regulation of genetic information
Lymphatic endothelial cells.
|Tucker, Chandra L.|
Protein engineering and optogenetics
Regulation of growthand host cell differentiation in viral infection and persistence.
Host response to intracellular pathogenic microorganisms
Development, regeneration, and diseases of multiciliated airway epithelia
Mycobacterium tuberculosis survival during latent disease.
Genomic instability and cancer development
Head, Neck, and Skin Cancer Research
Transcriptional regulation of mouse embryonic development
Molecular mechanism of pre-mRNA splicing