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Molecular Biology Faculty

The research interests of the more than forty program faculty include structure and function of nucleic acids, mechanisms of DNA replication, RNA transcription and mRNA translation, the structure and function of viruses, genes and gene products controlling cell cycle progression, cell death and development, protein trafficking, signal transduction, hormone receptors, and structural biology. To study these important and exciting fields, our faculty employ experimental systems such as bacteria, viruses, yeast cells, Xenopus oocytes, Drosophila, C. elegans, human tissue culture cells, and genetically engineered mice. Our faculty also provide training in high resolution structure of proteins and RNA/DNA by x-ray crystallography and NMR. Because of the solid funding record of all participating faculty, graduate students find unlimited opportunities to perform research in an atmosphere of both guidance and freedom.

Research Description
Anderson, Steven
Mammary gland development and tumorigenesis.
Appel, Bruce
Development and repair of the vertebrate nervous system
Artinger, Kristin
Patterning of the early spinal cord (neural plate) during vertebrate embryogenesis.
Asturias, Francisco
Cryo-EM of macromolecular machines
Barton, David
Enterovirus RNA replication.
Bates, Emily
Molecular mechanisms of pediatric disorders
Bayer, Ulli
Molecular memory and synaptic plasticity
Bentley, David
Eukaryotic mRNA biogenesis
Black, Joshua
Regulation of genome stability
Bradford, Andrew
Regulation of tissue specific gene expression in response to hormonal and growth factor stimuli, characterization of fibroblast growth factor signaling in the pituitary, and the role of protein kinase C in endometrial cancer.
Catalano, Carlos
Molecular mechanisms of virus development
Churchill, Mair
Structural biology of gene regulatory mechanisms
Colgan, Sean
Epithelial and endothelial cells in inflammatory bowel disease.
D'Alessandro, Angelo
Systemic responses to acute or chronic hypoxia.
Davis, Richard
Programmed DNA elimination, novel RNAs, and RNA metabolism.
DeGregori, James
Cancer evolution and dependencies.
DiPaola, Jorge
Human diseases of the hemostatic system
Duerkop, Breck
My lab studies bacterial viruses (known as bacteriophages) and their interactions with their hosts. We aim to understand 1) how intestinal bacteriophages contribute to host-microbe interactions and their overall impact on human health and 2) the molecular mechanisms of bacteriophage infection of multidrug resistant bacteria.
Eisenmesser, Elan
Viral protein/host protein interactions and enzyme motions.
Ernst, Patricia
Hematopoietic Stem Cell Development and Maintenance
Evans, Chris
Regulation of respiratory health and disease by airway mucins
Evans, Thomas
The control of embryonic polarity.
Fantauzzo, Katherine
Receptor tyrosine kinase signaling in mammalian craniofacial development
Ford, Heide
SIX family homeobox genes in development, cell cycle control and tumorigenesis.
Gerber, Anthony
Glucocorticoid receptor signaling, inflammatory response, and lung function.
Gutierrez-Hartmann, Arthur
Role of Ets transcription factors in breast cancer.
Hagman, James
Regulation of B lymphocyte specific transcription and differentiation
Hesselberth, Jay
Nucleic acid damage and repair
Holers, Michael
Complement receptor signal transduction
Hu, Cheng-Jun
Role of hypoxic response in tumor progression and metastasis
Huang, Mingxia
Function and regulation of the DNA damage response.
Hughes, Ethan
Oligodendrocytes and their Precursors in the Adult Central Nervous System.
Jagannathan, Sujatha
mRNA surveillance in health and disease
Johnson, Aaron
Formation and regulation of chromatin domains and their roles in the nucleus.
Johnston, Mark
Functional genomics, glucose sensing and signaling.
Jones, David
Proteins and nucleic acids structure-function
Jordan, Craig
The characterization and targeting of leukemia stem cells.
Kieft, Jeffrey
RNA structure and plasticity
Kutateladze, Tatiana
Structural biology of epigenetics and deciphering the histone code
Liu, Changwei
The ubiquitin proteasome pathway.
Macklin, Wendy
Oligodendrocyte Differentiation and Myelination in the Central Nervous System
Martin, Sandy*
Differential gene expression during hibernation.
McManaman, James
Lactation and Lipid secretion.
McMurray, Michael
Assembly and inheritance of dynamic macromolecular structures
Moore, Jeff
Molecular regulation of the microtubule network in cell division and disease
Mukherjee, Neelanjan
Systems Biology of Human RNA Regulatory Networks
Nichols, James
Skeletal development and variability.
Pearson, Chad
Centriole assembly and function
Pietras, Eric
Inflammation and hematopoiesis
Potter, Huntington
Neurodegenerative diseases and Down Syndrome
Prekeris, Rytis
Regulation of cell division, cell polarity and cell migration
Ramanchandran, Srinivas
Nucleosome structure and dynamics in cells
Reis, Tânia
Obesity and Neuronal Control of Energy Balance
Reyland, Mary
Regulation of apoptosis in epithelial cells by signal transduction pathways.
Richer, Jennifer
Estrogen and progesterone receptors in breast and gynecological cancers
Rissland, Olivia
RNA post-transcriptional, decay and mechanisms of translational regulation.
Russ, Holger
Functional human pancreatic and thymic cells to understand autoimmune diabetes.
Sikora, Matthew
Response and resistance to steroid hormones and anti-estrogen therapies in breast cancer.
Sussel, Lori
Transcriptional networks that regulate pancreas development and differentiation
Taliaferro, Matt
Spatial regulation of genetic information
Tamburini, Beth
Lymphatic endothelial cells.
Tucker, Chandra L.
Protein engineering and optogenetics
VanDyk, Linda
Regulation of growthand host cell differentiation in viral infection and persistence.
Vázquez-Torres, Andrés
Host response to intracellular pathogenic microorganisms
Vladar, Eszter
Development, regeneration, and diseases of multiciliated airway epithelia
Voskuil, Martin
Mycobacterium tuberculosis survival during latent disease.
Wang, Jing
Genomic instability and cancer development
Wang, Xiao-Jing
Head, Neck, and Skin Cancer Research
Transcriptional regulation of mouse embryonic development
Zhao, Rui
Molecular mechanism of pre-mRNA splicing
​* Non-training faculty member

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