Signal Transduction by cytokine receptors, breast cancer.
Development and repair of the vertebrate nervous system
Molecular, genetic, and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis.
Enterovirus RNA replication.
Molecular memory and synaptic plasticity, cellular signal transduction and neuronal function, CaMKII and Ca2+ signaling.
Eukaryotic mRNA biogenesis: transcription and RNA processing.
Regulation of tissue specific gene expression in response to hormonal and growth factor stimuli, characterization of fibroblast growth factor signaling in the pituitary, and the role of protein kinase C in endometrial cancer.
Visual system development and function using molecular-genetic approaches in Drosophila.
Structural biology of gene regulatory mechanisms
Understanding how epithelial and endothelial cells coordinate inflammatory bowel disease.
Novel forms of RNA, RNA metabolism, and chromatin diminution.
Leukemia initiation and maintenance
Viral protein/host protein interactions and enzyme motions
The control of embryonic polarity.
The SIX family of homeobox genes and their role in development, cell cycle control and tumorigenesis.
Forward genetics of mouse & human retinal diseases; functional studies of identified genes
TAM family of Receptor Tyrosine Kinases (RTKs) and how these RTKs contribute to the development and progression of human cancer
My laboratory focuses on two main projects: (1) elucidating the molecular mechanisms governing pituitary-specific gene expression; and, (2) determining the role of Ets transcription factors in breast cancer.
Regulation of B lymphocyte - specific transcription and differentiation
Genomics of gene regulation.
Signal transduction through complement receptors.
Virus receptors and their roles in virus pathogenesis and evolution.
Molecular characterization of bacterial toxins - gene regulation in pathogenic bacteria.
Molecular genetics of pattern formation -- Drosophila segmentation
Membrane traffic in both exocytic and endocytic pathways.
Role of hypoxic response in tumor progression and metastasis
Function and regulation of the DNA damage response.
Estrogen actions , Endometrial Cancer
Mechanisms of chromatin-mediated gene silencing.
Functional genomics, glucose sensing and signaling.
How the three-dimensional structure of proteins and nucleic acids controls their biological function. NMR is used to study the structure and dynamics of biological molecules implicated in the development and progression of disease.
Control of translation by RNA structure. RNA-protein interactions.
Biochemistry and Structural Biology; determination of the three-dimensional structures of proteins implicated in cancer by NMR spectroscopy and X-ray crystallography; the study of epigenetics and deciphering the histone code; molecular mechanisms of protein-phospholipid interactions; structure-based drug design.
The ubiquitin proteasome pathway.
Replication of mammalian mitochondrial (mt) DNA.
Biochemical and molecular basis of the control of cell division.
Mechanism of LINE-1 retrotransposition. Differential gene expression during hibernation.
Lactation and Lipid secretion.
Mechanisms of assembly and inheritance of dynamic macromolecular structures: Higher-order septin assemblies in budding yeast
Molecular basis of sister chromatid cohesion and chromosome segregation.
Research description: Molecular regulation of the microtubule network in cell division and disease
Genetic and Cellular Control of Vertebrate Embryonic Development
Molecular mechanisms of steroid receptor mediated regulation of gene expression. Regulation of oncogene and mammary tumor virus transcription.
Centriole assembly and function
Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons.
Human Papillomaviruses (HPVs)
The Genetic Basis of Obesity and Neuronal Control of Energy Balance in Drosophila melanogaster
Regulation of apoptosis in epithelial cells by signal transduction pathways.
Skin development and disease.
Gene therapy vectors; adenovirus preterminal protein function in the regulation of the infectious cycle
The regulation of the eukaryotic cell cycle.
Apoptosis regulation in cancer development and treatment.
|Tucker, Chandra L.|
Study and manipulation of protein homeostasis and signaling pathways in live cells, optogenetic tools for controlling protein interactions, synthetic biology, cytosolic protein misfolding, yeast genetics/genomics
Control of growth regulation and differentiation of host cells in viral infection and persistence.
Molecular mechanisms of bacterial pathogenesis and gene regulation in procaryotes, including Mycobacteria tuberculosis and Pseudomonas aeruginosa.
Understanding the role that mononuclear phagocytes play in the host response to intracellular pathogenic microorganisms
Mechanisms of Mycobacterium tuberculosis for survival during latent disease.
Genomic instability and cancer development; molecular mechanisms of somatic hypermutation and class switch recombination; metastasis and genomic instability.
Head, Neck, and Skin Cancer Research
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer.
Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer