Enterovirus RNA replication.
Structural biology of gene regulatory mechanisms
How the three-dimensional structure of proteins and nucleic acids controls their biological function. NMR is used to study the structure and dynamics of biological molecules implicated in the development and progression of disease.
RNA structure and plasticity, viral RNA manipulation of host cell machines and enzymes, RNA-protein interactions, ribosome structure and function, use of RNA in engineered nanomachines, development of new tools for structural biology.
Biochemistry and Structural Biology; determination of the three-dimensional structures of proteins implicated in cancer by NMR spectroscopy and X-ray crystallography; the study of epigenetics and deciphering the histone code; molecular mechanisms of protein-phospholipid interactions; structure-based drug design.
The ubiquitin proteasome pathway.
Mechanisms of assembly and inheritance of dynamic macromolecular structures: Higher-order septin assemblies in budding yeast
Centriole assembly and function
Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer