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Areas of Research

Gene Expression: RNA Transcription, mRNA Translation, Epigenetics

Gene Expression
Faculty study the regulation of the flow of genetic information from the DNA to RNA to proteins and to important cellular structures.
Associated Faculty Members
 Results From Molecular Biology : Selected site and subsites
Faculty NameResearch Description
Bates, Emily
The use of genetics to determine the molecular mechanisms of pediatric disorders.
Bentley, David
Eukaryotic mRNA biogenesis: transcription and RNA processing.
Churchill, Mair
Structural biology of gene regulatory mechanisms
Davis, Richard
Programmed DNA elimination, novel RNAs, and RNA metabolism.
Ernst, Patricia
Hematopoietic Stem Cell Development and Maintenance: The Role of the "Mixed Lineage Leukemia" Gene in Normal Blood Cell Development, Differentiation and Leukemia.
Evans, Thomas
The control of embryonic polarity.
Ford, Heide
The SIX family of homeobox genes and their role in development, cell cycle control and tumorigenesis.
Gerber, Anthony
The inter-relationship of glucocorticoid receptor signaling, inflammatory response, and lung function.
Gutierrez-Hartmann, Arthur
My laboratory focuses on two main projects: (1) elucidating the molecular mechanisms governing pituitary-specific gene expression; and, (2) determining the role of Ets transcription factors in breast cancer.
Hagman, James
Regulation of B lymphocyte - specific transcription and differentiation
Hesselberth, Jay

Genomics of DNA and RNA Repair

Hooper, Joan

Cell and tissue interactions that control development and tissue homeostasis.

Hu, Cheng-Jun
Role of hypoxic response in tumor progression and metastasis
Johnson, Aaron
Our work focuses on the formation and regulation of chromatin domains and their ultimate roles in the nucleus. We are particularly interested in the mechanisms of heterochromatin establishment and function.
Johnston, Mark
Functional genomics, glucose sensing and signaling.
Jones, David
How the three-dimensional structure of proteins and nucleic acids controls their biological function. NMR is used to study the structure and dynamics of biological molecules implicated in the development and progression of disease.
Kieft, Jeffrey
RNA structure and plasticity, viral RNA manipulation of host cell machines and enzymes, RNA-protein interactions, ribosome structure and function, use of RNA in engineered nanomachines, development of new tools for structural biology.
Kutateladze, Tatiana
Biochemistry and Structural Biology; determination of the three-dimensional structures of proteins implicated in cancer by NMR spectroscopy and X-ray crystallography; the study of epigenetics and deciphering the histone code; molecular mechanisms of protein-phospholipid interactions; structure-based drug design.
Martin, Sandy
Mechanism of LINE-1 retrotransposition. Differential gene expression during hibernation.
VanDyk, Linda
Control of growth regulation and differentiation of host cells in viral infection and persistence.
Vasil, Michael
Molecular mechanisms of bacterial pathogenesis and gene regulation in procaryotes, including Mycobacteria tuberculosis and Pseudomonas aeruginosa.
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer.
Zhao, Rui
Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer