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CFReT Focus


CFReT Focus Figure 

Existing Strengths

Investigators in the CFReT possess significant strengths and unique capabilities for discovering novel mechanisms that govern pathological fibrosis, and for the treatment of patients with diverse fibrotic diseases. 


  • Expertise in the treatment of patients with fibrotic disorders and in clinical trial design
  • Expansive bank of fibrotic human tissues and normal controls
  • Injectable hydrogels for sustained delivery of anti-fibrotic therapies
  • State-of-the-art rodent models of fibrosis in diverse tissues
  • Multi-pronged approach for fibrosis quantification
  • Induced pluripotent stem (iPS) cells to unravel molecular mechanisms of fibrosis
  • Expertise in signaling and gene regulatory mechanisms controlling fibrosis
  • Computational biology and whole-genome/proteome analyses
  • Tunable hydrogels for assessing the impact of tensile strength on fibroblast phenotype
  • Small molecule drug discovery
  • High content imaging for chemical biology and whole-genome screening


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