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Dongying Li

CSD Graduate Student

CSD Graduate Student - Donying Li

E-Mail: Dongying Li

Lab Phone: 303-724-3410

First Year Lab Rotations:

Rotation 1: Rytis Prekeris Lab (2008): I investigated the role of Kinesin 1 and FIP3 in cytokinesis.

Rotation 2: Karen King Lab (2009): I tested the effect of different osteogenic component compounds on osteoblast growth.

Rotation 3: Dennis Roop Lab (2009): I investigated the role of K75 in hair follicle development and regeneration.

Thesis Advisor:   Rytis Prekeris

Current Research:

The plasma membrane in polarized epithelial cells are divided into two domains: the apical and basolateral. Different compositions of proteins in these two domains require the proper endosome-dependent protein transport to their specific membrane compartment. I am interested in the apical protein recycling in which the components internalized from the apical plasma membrane are transported back to the apical domain. The Rab11 small GTPase interacting with its binding partner Rip11 is known to regulate this process in polarized MDCK epithelial cells. It has also been shown that Rip11 binds to the motor protein Kinesin 2 mediating the endosomal recycling in non-polarized HeLa cells. I am characterizing the interaction between Rip11 and Kinesin 2, and also investigating how this interaction mediates the delivery of the cargo-carrying endosomes to the apical plasma membrane.

Selected Presentations:

  • Comprehensive Exam Presentation, September 21, 2010:
  • "The Role of FIP5/Rip11 and Kinesin II in Epithelial Protein Trafficking"

    Undergraduate Education:

    Bachelor of Science, Biological Sciences, Nankai University, China, 2008.

    Undergraduate Research: I was working on how the HIV Tat protein interacting with Aurora-B kinsase in the host cells promotes cell proliferation and induces cancer.

    Why did you decide to pursue a PhD in Cell Biology, Stem Cells & Development?

    My major in college was Biological Science which is a very broad field. My favorite course was Cell Biology and the textbook cover was an image of a metaphase cell stained for spindle microtubules and chromosomes. To me, that is the most beautiful image in the world. I was, and still am, amazed by the fact that cell, such a small unit, is so well organized and that the underlying mechanisms are so sophisticated. I knew there was still a lot to learn, and to explore. That is why I decided to pursue a PhD in cell biology.

    Why did you choose CU's Anschutz Medical Campus?

    UCD-AMC campus is newly built and well equipped. We do not have to teach which helps focus on research. I like the city of Denver. It is not as big as the New York city where it is hard to find a piece of quiet when you want to. Nor is it a small town where you are probably too easy to get bored. Denver is just right! There are a lot of outdoor activities one can have, such as hiking, camping and skiing. So here we get to work hard and play hard.

    What has been most suprising to you since you started graduate school?

    People here are nice and willing to help, which makes life easier in graduate school.

    Where did you grow up?

    Hohhot, China.

    When did you start the graduate program at Anschutz Medical Campus?

    Fall, 2008.

    What do you do for fun?

    Swimming, ice-skating, skiing.

    What do you like about living in Colorado?

    300+ sunny days in a year helps keep me in a good mood.