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Faculty and Research

Bruce Appel, PhD

Professor
Director, Cell Biology, Stem Cells and Development Program
Contact Bruce Appel

Elizabeth Wethington

Program Administrator
Cell Biology, Stem Cells and Development
Contact Elizabeth

We are an interactive group, with a strong emphasis on collaboration and cooperation. Faculty are deeply engaged in student mentoring; they provide both oversight and support as students work toward their doctoral degree. The intent is to train students as future academic peers, and provide a rigorous and engaging intellectual environment for all program members.

Members of the CSD Program currently include:

  • 34 full time PhD students
  • 51 faculty from 16 academic and clinical departments

Faculty

Faculty participating in the CSD Program hail from 8 diverse biomedical departments, yet are intellectually linked through our graduate program by their common research interests. Moreover, our 43 faculty members and their labs further align themselves with, but are not restricted to, 1 or more of 6 research sub-areas under the umbrella of our CSD Program:

  • Anesthesiology
  • Biochemistry and Molecular Genetics
  • Cardiovascular and Pulmonary
  • Cell & Developmental Biology
  • Craniofacial Biology
  • Dermatology
  • Endocrinology
  • Gastroenterology
  • Immunology
  • Medical Oncology
  • Obstetrics and Gynecology
  • Orthopedics
  • Otolaryngology
  • Pathology
  • Pediatrics

Faculty List

Cell Biology
Research
Stem Cells
Research
Development
Research
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Development and repair of the vertebrate nervous systemNoYesNo
Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesisNoNoNo
Developmental neurobiology; patterning and formation of sensory organsNoYesYes
Mechanisms underlying developmental signaling in mice and in fruit flies and genetic modeling of human disordersNoYesNo
Molecular mechanisms underlying bone resorption by osteoclasts and the mechanism/s mediating pathological bone loss following Spinal Cord Injury (SCI).YesNoNo
Structural analysis of protein glycosylation using NMR and mass spectrometryYesNoNo
Cellular heterogeneity and electrical synapse plasticity in pancreatic islet function, and dysfunction in diabetes, ageing and therapeutic treatmentsYesNoNo
Clinical interventions combined with mechanistic investigations by using primary human cell culture modelsNoYesNo
Development of the mammalian retinaNoYesNo
Functional regulation of ion channels in plasma membranes and Golgi membranes using electrophysiology and molecular biologyYesNoNo
Signaling pathways regulating craniofacial and cardiovascular developmentNoYesNo
Programmed DNA elimination, novel RNAs, and RNA metabolismYesNoNo
Cancer Evolution and Cancer Signaling PathwaysYesNoNo
Extracellular Signals in Intestinal Stem Cell NicheNoNoYes
The role of circadian rhythm proteins in cellular adaptation to hypoxia and ischemiaYesNoNo
Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approachesYesYesNo
Receptor tyrosine kinase signaling in mammalian craniofacial developmentYesNoNo
Development and organization of taste and smellNoYesNo
Neural stem cell fate-specification, neurogenesis, cell migration and circuit formation in the developing CNSNoYesNo
Cell determination, developmental patterning and hedgehog signaling in drosophilaYesYesNo
Oligodendrocytes and their Precursors in the Adult Central Nervous SystemNoNoNo
mRNA surveillance in health and diseaseYesNoNo
Cell adhesion molecules in embryonic development and diseasesNoYesYes
Seek to understand how the lung repairs itself, and to create new approaches to repairing and regenerating lung tissueNoYesYes
Signaling pathways that control epidermal development and differentiationNoNoYes
Molecular, cellular and genetic basis of neurodevelopmental mechanisms involved in risk for schizophrenia and other psychiatric disordersYesYesNo
Molecular mechanisms and targeted therapies for squamous cell carcinomasYesNoNo
Mechanisms of lymphatic mediated metastasis of breast cancer.NoYesNo
Oligodendrocyte development and diseaseYesYesNo
Mammary gland development and functionYesNoNo
Mechanisms of assembly and inheritance of dynamic macromolecular structures: Higher-order septin assemblies in budding yeastYesNoNo
Molecular regulation of the microtubule network in cell division and diseaseYesNoNo
Skeletal development and variabilityNoYesNo
Genetic mechanisms of limb, lung, and neural developmentNoNoNo
The therapeutic potential of bone marrow stem cells and induced pluripotent stem cells.NoNoNo
Cell biology of the cytoskeleton: Centriole assembly and functionYesNoNo
Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neuronsYesYesNo
The role of MYC in the regulation of hematopoietic stem cell self-renewal, proliferation, differentiation and survivalNoNoYes
The Genetic Basis of Obesity and Neuronal Control of Energy Balance in Drosophila melanogasterYesYesNo
Olfactory signal transduction and olfactory sensory coding using electrophysiological, morphological and molecular techniquesYesYesNo
Role of protein kinase C delta signaling in apoptosis and cancerYesNoNo
Post-transcriptional gene regulation; mRNA decay; translationYesNoNo
Skin development and diseaseNoYesYes
Our laboratory is interested in insulin-producing pancreatic beta cells in health and disease.YesNoNo
CNS vascular development and stabilityNoYesNo
Mechanisms governing cardiomyocyte lineage commitment and pathogenesis of cardiomyopathiesYesYesNo
Our lab is primarily focused on molecular mechanisms underlying abnormal placental blood flow and function.YesYesNo
The main focus of our research is to understand the complex transcriptional networks that regulate development, differentiation and function of the pancreasNoYesNo
Gene expression; subcellular RNA localization; localized translation in neurons; high-throughput screening; RNA-seqYesNoNo
The study and manipulation of protein interactions and pathways, including protein homeostasis and signaling pathways; developing novel technologies that allow use of light for photocontrol of protein function.YesNoNo
Pediatric Oncology & Neuro-Oncology with an emphasis on medulloblastoma.YesNoNo
How multiciliated cells adopt their cell fate, build cilia and orient the cilia for directional clearance during normal development, regeneration and human disease.YesNoNo
TGFbeta signaling in cancer and skin developmentYesYesYes
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancerNoYesNo

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