Skip to main content
Sign In
 

Crnic Grand Challenge Grants Program

Proposals


Purpose of the Crnic Seed Grant

 
 

The Linda Crnic Institute for Down Syndrome, a unit of the University of Colorado housed on both the Anschutz Medical and Boulder campuses, is working to eliminate the ill effects of Down syndrome.  The Institute plans to accomplish this goal by supporting research likely to aid in the understanding of the syndrome and in reducing its adverse consequences.  Exciting new technologies in genomics, proteomics, transcriptomics, genetics, stem cell biology, gene knockouts, microscopy, etc. are enabling novel and powerful approaches to age-old and important questions, and are enabling our Down syndrome community to make significant strides towards these goals.

 
 

Generous gifts from the Anna and John J. Sie Foundation and donors to the Global Down Syndrome Foundation, as well as significant support from the CU-Boulder and CU-Denver Chancellors’ Offices, provide funding for grants to initiate research projects on the mechanisms whereby three copies of chromosome 21 lead to Down syndrome and on ways to ameliorate the ill effects in those who currently have Down syndrome. These research grants are available to University of Colorado faculty on either campus who now study Down syndrome or who are interested in initiating projects to do so.  Each laboratory is limited to a total $100,000 annually from this program.  Our purpose is to create a vibrant, exciting and active research community dedicated to solving the key DS-related issues outlined on pages 3 - 5 in the Application and Overview Requirements. The members of the Crnic Institute and our grantees are working together, making the University of Colorado a powerhouse in this area.

 

Grand Challenge Grant Program Leadership and Management

For questions or assistance with the Grand Challenge Grants Proposals, please contact:

           303-724-6599

 

 

 Grand Challenge Grantees

 
Attachments
  
  
  
  
Body
  
Yes1
Bettcher, Brianne.jpg
2016 Grantee
​Denver
Alzheimer's and Down syndrome
  
Yes
Bilousova, Ganna.jpg
2016 Grantee
Denver
Down syndrome stem cells
  
Yes
Chen, Zhe.jpg
​2014 Grantee
Boulder
Trisomy 21 effectove on neural path finding
  
Yes

​2013 & 2014 Grantee
Denver
Leukemia in Down syndrome

  
Yes
dellacquaMark.jpg
​2014 Grantee
Denver
Synaptic transmission in trisomic cells
  
Yes
​2013 & 2014  Grantee
Boulder
Gene expression in Down syndrome
  
Yes
Espinosa - Headshot.jpg
​2013 Grantee
Denver
Altered cell signaling in Down syndrome
  
Yes
Hansen, Kirk.jpg
2016 Grantee
Denver
Proteomics of Down syndrome
  
Yes
​2013 Grantee
Denver
Anesthesia sensitivity in Down syndrome
  
Yes
Charles Hoeffer.jpg
​2015 Grantee
Boulder
Effect of trisomy on behavior in Down syndrome mice
  
Yes
Johnson, Aaron.jpg
2014 Grantee
Denver
Structure and function of chromosome 21
  
Yes
​2013 & 2015 Grantee
Boulder
Rescue of Down syndrome mice by BDNF overexpression
  
Yes
Junge, Harald.jpg
2014 Grantee
Boulder
Optic development in Down syndrome
  
Yes
Matthew Kennedy.jpg
2015 Grantee
Denver
Neurotransmission in Down syndrome
  
Yes
Klymkowsky, Michael.jpg
2016 Grantee
Boulder
Neurodevelopment in Down syndrome
  
Yes
2013 & ​2014 Grantee
Boulder
Gene expression in Down syndrome iPSCs
  
Yes
Liu, Changwei.JPG
2015 & 2016 Grantee
Denver
Effect of USP16 overexpression on protein degradation
  
Yes
Ken Maclean.jpg
2015 Grantee
Denver
Does Down syndrome induce the unfolded protein response?
  
Yes
Maier, Steven.JPG
​2014 & 2016 Grantee
Boulder
Neuroinflammation in Down syndrome mice
  
Yes
William Old.jpg
2015 & 2016 Grantee
Boulder
Effect of DYRK1A overexpression in Down syndrome
  
Yes
​2014 & 2015 Grantee
Boulder
Effective of trisomy on muscle stem cells
  
Yes
Pearson, Chad.jpg
​2016 Grantee
Denver
Cell signaling in Down syndrome
  
Yes
2014 & 2015 Grantee
Denver
Immune dysfunction in Down syndrome
  
Yes
​2013 & 2014 Grantee
Denver
APP mis-expression in Down syndrome
  
Yes
Porter, Chris.jpg
2016 Grantee
Denver
Immune system in Down syndrome cells
  
Yes
​2013 & 2014 Grantee
Denver
Autisum and Down syndrome
  
Yes
​2013 Grantee
Denver
Autoimmune disorders in Down syndrome
  
Yes
Jerry Stitzel.jpg
2015 Grantee
Boulder
Alzheimer's symptoms in Down syndrome mice
  
Yes
Sullivan, Kelly.jpg
​2016 Grantee
Denver
Interferon signaling in Down syndrome
  
Yes
​2013 Grantee
Boulder
Cell death in Down syndrome
1 - 30Next