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Down syndrome,
or Trisomy 21, is:

  • A condition whereby there are three copies of the 21st chromosome instead of two.
  • One of the leading clinical causes of cognitive delay in the world.
  • The most frequently occurring chromosomal condition, affecting approximately 1 in every 700 births in the United States.

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New Leadership at the Linda Crnic Institute for Down Syndrome





Tom Blumenthal has served as Executive Director for the pas​t five years is excited to pass the baton to another brilliant scientific mind, Joaquin Espinosa.  Dr. Espinosa accepted the task effective July 2017.  He is also a Professor in the Department of Pharmacology at the University of Colorado Denver School of Medicine, the co-Leader of the Molecular Oncology program at the University of Colorado Cancer Center, and the founding Director of the Functional Genomics Facility at the University of Colorado. Dr. Espinosa is also the leader of the Human Trisome Project (Crnic HTP) which is the largest and most comprehensive study of its kind. Crnic HTP will help us understand why individuals with Down syndrome (trisomy 21) are protected from some medical conditions, such as cancer, while highly predisposed to others, such as Alzheimer's disease.  This research will serve the population with Down syndrome, but also the millions of individuals without Down syndrome who are affected by the many medical conditions modulated by trisomy 21.​