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Interdisciplinary Transcranial Magnetic Stimulation (TMS) Lab

Director: Dr. Benzi Kluger, MD

Steering Committee: Marshall Thomas, MD; Margaret Schenkman, PhD

The UCD Interdisciplinary TMS Laboratory is dedicated to improving our understanding of diseases affecting the central nervous system and developing treatments for these conditions. Our associated faculty includes members of the Departments of Neurology, Psychiatry, Physical Medicine and Rehabilitation, Orthopedics, Internal Medicine, Psychology and Speech, Language and Hearing Sciences. Areas of research interest include the treatment of psychiatric disorders, improving rehabilitation and speech therapy outcomes, investigating the neurophysiology of movement disorders and integrating TMS with other imaging modalities (MRI, MEG and EEG).

Transcranial Magnetic Stimulation (TMS) is rapidly becoming one of the most important research tools in clinical neuroscience. TMS utilizes rapid magnetic pulses applied over the scalp with a small hand-held coil to induce precisely timed and localized electrical currents within the cortex of human subjects. TMS is also being used in clinical research in the diagnosis of diseases affecting the corticospinal tract, the planning of neurosurgical procedures and the treatment of many conditions, including depression, hallucinations, pain, tinnitus, Parkinson’s disease and stroke rehabilitation.

 

TMS set up 

Effects of Mental Concentration on the Responsiveness of Intra-cortical and Corticospinal Pathways
Katrina Maluf, PT, PhD

Mental concentration can increase trapezius muscle activity in some, but not all, individuals. This project uses transcranial magnetic stimulation (TMS) to investigate individual differences in the effects of mental concentration on the responsiveness of intra-cortical and corticospinal pathways in subjects with and without chronic neck pain and cervical dystonia.

 

 

Optimizing Lower Extremity Muscle Function after Total Knee Arthroplasty
Jennifer Stevens-Lapsley, PT, PhD

The goal of this study is to investigate quadriceps force and reflex inhibition after TKA and explore rehabilitation strategies to minimize these deficits after TKA.

 

 

 

 

Study of the Neurophysiology of Central Fatigue
Benzi Kluger, MD, MS

The goal of this study is to determine how changes in tasks demands affect the neurophysiology of motor fatigability and to measure how changes in cortical excitability correlate with cognitive fatigability.

 

 

 

 

A Novel Approach to Cognitive Dysfunction in Parkinson's Disease
Benzi Kluger, MD, MS

This study combines rTMS and magnetoencephalography to investigate the etiology of cognitive dysfunction in Parkinson's disease as well as the potential of rTMS to ameliorate these symptoms.

 

 

 

Director: Dr. Benzi Kluger

LAB MEMBERS

 

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Lab Director
Steering Committee
Affiliated Departments/Programs and Investigators

ACTIVE GRANTS

Department of Defense (ARO #56700-LS) 
Study of the Neurophysiology of Central Fatigue  
PI, Kluger B.
$325,000

NIH/NCRR Colorado CTSI (KL2 RR025779) 
Novel Approach to Cognitive Dysfunction in Parkinson’s Disease  
PI, Kluger B.
$338,700

NIH (R01-HD065900) 
Progressive Rehabilitation for Total Knee Arthroplasty 
PI: Stevens-Lapsley, Co-investigator: Kluger B.
$2,469,362

RECENTLY COMPLETED GRANTS

Michael J. Fox Foundation (R01-AR056704) 
Repetitive Transcranial Magnetic Stimulation for the Treatment of Apathy in Parkinson’s Disease (The ReStore Study) 
Fernandez HH, Principal Investigator; Co-investigator: Kluger B.
$400,000

Academy of Neurology Foundation (R01-AR056704) 
Study of the Neurophysiology of Central Fatigue in Parkinson’s disease and Stroke. 
PI, Kluger B.
$130,000

RECENT PUBLICATIONS

Kluger BM, Triggs WJ. Use of transcranial magnetic stimulation to influence behavior. Curr Neurol Neurosci Rep. 2007 Nov;7(6):491-7.

Triggs WJ, Ricciuti N, Ward HE, Cheng J, Bowers D, Goodman WK, Kluger BM, Nadeau SE. rTMS Treatment of refractory depression: Stimulus laterality effect exceeds rTMS effect. Psychiatry Res. In Press.

LABORATORY EQUIPMENT

The TMS Lab is equipped with Magstim standard figure of eight coils as well as specialized coils for repetitive applications and targeting of deeper cortical structures. Our stimulators are capable of delivering single pulse, paired pulse, and repetitive stimulation. Our Brainsight neuronavigation system allows stereotactic delivery of TMS pulses based on neuroimaging (MRI). We also have an advanced electromyography (EMG) system and Signal software for research applications.

The TMS facility, like MRI and MEG, is available as a fee for service. Basic service includes preparatory time and TMS stimulation time and is billed based on time of use. Training in the application of TMS paradigms and a TMS technician are also available for an additional fee. Investigators interested in using TMS will need to submit a Study Protocol Request (see link below) which will be reviewed by the steering committee. TMS faculty may also be consulted regarding aspects of experimental design and/or data analysis.

Services:

Review of proposals using TMS, assistance with preparation of IRB materials for TMS projects, training in the use of TMS and stereotactically guided TMS, performance of TMS on human subjects for research and therapeutic purposes. Download a brochure about TMS

Fees:

TMS conducted on human subjects will be $200/hour for internal users and $400/hour for investigators outside of the University of Colorado. Other services and discounts for collection of pilot data or junior investigators may be discussed with Dr. Kluger and the steering committee.

FREQUENTLY ASKED QUESTIONS

 

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How is the quality of your measurements evaluated – quality control?
What is the turn-a-round time for the service you provide?
Who documents the data provided and signs off on the data?
Have you had experience providing data for industry?
Do you have a standard operating procedure manual?
How will you track billing and financial aspects of your core?

LAB CONTACT INFORMATION 

Lab Address:

Anschutz Medical Campus
Bldg 500, Rm EG305
13001 E. 17th Place         
Aurora, CO 80045
 
Phone:
303-724-5470 Office
303-724-0863 Fax 
 
Email: TMS.Lab@ucdenver.edu
   

MAP and DIRECTIONS to find the TMS lab on the Anschutz Medical Campus

EMPLOYMENT AND TRAINING OPPORTUNITIES