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Title

Pseudomonas aeruginosa drug efflux pump and metabolism

Project Description

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that can infect almost any site of the body and is highly resistant to antibiotics. The organism is most infamous for chronic pneumonia of patients afflicted with cystic fibrosis and the third leading cause of hospital-acquired infections. The microorganism is quite adaptable to several different environmental conditions. We have been studying its ability to adapt to the lung environment by dissecting a signal transduction system, called AlgZR, that controls many different phenotypes that are required for virulence. Recently, we have discovered that the organism's ability to efflux drugs is linked to fatty acid metabolism through a membrane-bound drug efflux pump. We will be testing the hypothesis that growth on fatty acids induces P. aeruginosa resistance to fluoroquinolones through the control of the MexEF oprN drug efflux pump.

Area of Study

Immunology and Autoimmune Diseases; Microbiology and Infectious Diseases

Populations

 

Method

Biomolecular Structure and Biochemistry; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Immune Related Disease; Infection; Lung Disease

Department

Immunology and Microbiology

Mentor Location

RC1North, lab room 9400A, office 9113

Mentor Contact Number

303.724.4221

Mentor Email

michael.schurr@ucdenver.edu

Website

 

Mentor Name

Schurr, Michael

Funding Department/Program

Immunology and Microbiology

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/5/2018 2:59 PM by Hom, Patrick H
Last modified at 8/5/2018 2:59 PM by Hom, Patrick H