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Title

The role of voltage-gated calcium channels in pain and anesthesia

Project Description

Our studies investigate how modulation of T-type calcium channels in peripheral sensory and CNS neurons affects their function and how different anesthetic and analgesic agents selectively target particular classes of voltage-gated ion channels. In particular, we are interested in testing new selective T-type channel blockers such as neuroactive steroids using functional studies of nociception and anesthetic end points in vivo. In these studies we will use mice lacking particular isoforms of T-type calcium channels, namely CaV3.1, Cav3.2 and Cav3.3 and our established animal models of painful diabetic neuropathy.

Area of Study

Neuroscience, Brain and Behavior - Adult; Pharmacology and Physiology

Populations

 

Method

Animal Models; Behavioral

Disease or Symptom

Diabetes; Pain

Department

Anesthesiology

Mentor Location

room L18-4100 RC1 south

Mentor Contact Number

303-724-9122

Mentor Email

slobodan.todorovic@ucdenver.edu

Website

 

Mentor Name

Todorovic, Slobodan

Funding Department/Program

Anesthesiology

Status

Current

Display on public listing?

No

Upload Date

5/25/2016 9:45

Attachments

Created at 5/25/2016 3:53 PM by Ross, Randy
Last modified at 8/4/2018 3:45 PM by Hom, Patrick H