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Title

Biomarkers of inflammation and oxidative stress in patients with kidney diseases

Project Description

Project 1. Our preliminary studies have shown that inflammation, oxidative stress, and endothelial dysfunction are evident in patients with chronic kidney dysfunction (CKD). At the current time, there is an immediate need for specific and sensitive biomarkers that can predict disease progression and stratify patients to those at risk to progress faster. With no approved treatment, control of hypertension and management of secondary features of chronic renal insufficiency are present clinical measures to slow the progression of disease.  Project 2: Calcineurin inhibitors are highly effective immunosuppressants used in patients with immune diseases and after transplantation. However, their use is limited by their toxic effects on the kidney and the induction of vascular endothelial dysfunction. Current clinical diagnostic markers are known to be insensitive and to only rise after significant damage has already occurred. The proposed study seeks to establish that the negative effects of the calcineurin inhibitor tacrolimus on kidney and vascular endothelial cells in adult and pediatric patients with nephrotic syndrome and after kidney transplantation are reflected by changes in plasma and urine metabolite and protein pattern changes and that these changes have better sensitivity and specificity compared to markers currently established in the clinic such as creatinine in serum.

Area of Study

Cardiovascular; Metabolism and Endocrinology; Pharmacology and Physiology

Populations

Adults; School Age Children; Young Adults

Method

Biomolecular Structure and Biochemistry; Cell Biology, Molecular Biology, and Genetics; Clinical Trials

Disease or Symptom

Kidney, Bladder, and Urethral Disease; Liver Disease

Department

Anesthesiology

Mentor Location

Bioscience II Building 12705 E Montview Blvd, Suite 200, Room 2304 Aurora, CO, 80045

Mentor Contact Number

303-724-5669

Mentor Email

Jelena.Klawitter@ucdenver.edu

Website

 

Mentor Name

Klawitter, Jalena

Funding Department/Program

Anesthesiology

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/26/2015 4:12 PM by Ross, Randy
Last modified at 8/14/2019 12:49 PM by Zoghby, Caitlin