This project is to explore development of and potential treatment of autoimmune diseases. We focus on type 1 diabetes and MS predominantly, but are beginning to study the role of autoimmunity in atherosclerosis and cardio-vascular disease. We do translational and reverse translational work. That is, we study how immune cells work in mice and identify the counterparts in human subjects, including autoimmune subjects. We also explore human disease states and determine if we can reverse translate to create appropriate mouse models for further study. The lab has generated a unique drug to control autoimmune inflammation and we are exploring how this drug may translate to T1D, MS and CVD.