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Title

Neural mechanisms of cross-sensistization in the pelvis and chronic pelvic pain

Project Description

Chronic pelvic pain (CPP) is a common symptom of many urologic and gastrointestinal disorders including interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS). Our group was at the forefront of the research efforts aimed at understanding the mechanisms underlying co-morbid CPP disorders and provided initial evidence that cross-sensitization via neural pathways triggers the development of neurogenic inflammation in the pelvis and chronic pelvic pain of unknown etiology. We determined that transient colonic inflammation causes neurogenic bladder dysfunction evaluated by cystometry, triggers hyperexcitability of bladder sensory and spinal neurons, increases pro-inflammatory neuropeptides in the bladder, and alters detrusor contractility.

Area of Study

Neuroscience, Brain and Behavior - Adult; Pharmacology and Physiology; Surgery

Populations

Adults

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Display on public listing?

No

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Attachments

Created at 8/26/2015 3:59 PM by Ross, Randy
Last modified at 5/18/2016 7:58 AM by Ross, Randy