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Title

Investigating epithelial cell derived factors that regulate intestinal immune responses.

Project Description

Inflammatory bowel disease (IBD) affects approximately 1.6 million people in the USA. These chronic illnesses are characterized by loss of intestinal epithelial cell integrity and pathogenic CD4T cell accumulation in the inflamed intestine. This project seeks to investigate how proteins produced at the epithelial cell surface regulate intestinal epithelial barrier function and the recruitment of pathogenic CD4T cells to the intestine. In vitro cell culture models and mouse models of intestinal inflammation will be used to study these processes.

Area of Study

Immunology and Autoimmune Diseases

Populations

Adults

Method

Animal Models; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Gastrointestinal Disease; Immune Related Disease

Department

Anesthesiology

Mentor Location

12700 E 19th Avenue RC-2

Mentor Contact Number

303-724-6245

Mentor Email

carol.aherne@ucdenver.edu

Website

https://profiles.ucdenver.edu/display/226074

Mentor Name

Aherne, Carol

Funding Department/Program

Anesthesiology

Status

Current

Display on public listing?

No

Upload Date

8/24/2015 11:15 AM

Attachments

Created at 8/24/2015 12:25 PM by Ross, Randy
Last modified at 8/14/2019 12:31 PM by Zoghby, Caitlin