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Title

Immune dysregulation in Inflammatory Bowel Disease

Project Description

50-80% of our body immune cells reside at our mucosal tissues. In particular our intestines are in a constant state of immune activation as they regulate the food and bacterial contents of our guts while maintaining physiologic function. This immune tolerance; is broken during the development of the autoimmune diseases such as Inflammatory Bowel Disease (IBD; namely, Crohn's disease and Ulcerative Colitis). We principally focus on dissecting the roles that cytokine, chemokine and miRNA networks play in regulating intestinal tolerance versus the progression to IBD. A central theme is to identify innovative approaches to target the break in mucosal immune tolerance, which drives pathogenic CD4+ Helper T cell subsets. Our ultimate goal is to translate our preclinical research into new therapeutic modalities for patients with IBD.

Area of Study

Immunology and Autoimmune Diseases

Populations

 

Method

Animal Models; Cell Biology, Molecular Biology, and Genetics; Imaging; Light Microscopy

Disease or Symptom

Gastrointestinal Disease; Immune Related Disease

Department

Anesthesiology

Mentor Location

Office # 7118, Research Center 2, Anschutz Medical Campus

Mentor Contact Number

3037241762

Mentor Email

eoin.mcnamee@ucdenver.edu

Website

http://profiles.ucdenver.edu/display/226064

Mentor Name

McNamee, Eoin (*Owen)

Funding Department/Program

Anesthesiology

Status

Closed

Display on public listing?

No

Upload Date

8/21/2015 12:32 PM

Attachments

Created at 8/21/2015 3:21 PM by Ross, Randy
Last modified at 8/14/2019 12:57 PM by Zoghby, Caitlin