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Project Description
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Chronic pelvic pain (CPP) is a common symptom of many urologic and gastrointestinal disorders including interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS). Our group was at the forefront of the research efforts aimed at understanding the mechanisms underlying co-morbid CPP disorders and provided initial evidence that cross-sensitization via neural pathways triggers the development of neurogenic inflammation in the pelvis and chronic pelvic pain of unknown etiology. We determined that transient colonic inflammation causes neurogenic bladder dysfunction evaluated by cystometry, triggers hyperexcitability of bladder sensory and spinal neurons, increases pro-inflammatory neuropeptides in the bladder, and alters detrusor contractility.
Neuroscience, Brain and Behavior - Adult, Pharmacology and Physiology, SurgeryAdultsNo
  
My lab studies the microbiome in humans and animal models and in a variety of disease contexts.  
Child-Maternal Health and Reproductive Sciences, Health Care and Public Health Research, Immunology and Autoimmune Diseases, Metabolism and Endocrinology, Microbiology and Infectious DiseasesAdults, Hispanic-Latino(a), Infants, Pregnant WomenNo
  
Project 1. Our preliminary studies have shown that inflammation, oxidative stress, and endothelial dysfunction are evident in patients with chronic kidney dysfunction (CKD). At the current time, there is an immediate need for specific and sensitive biomarkers that can predict disease progression and stratify patients to those at risk to progress faster. With no approved treatment, control of hypertension and management of secondary features of chronic renal insufficiency are present clinical measures to slow the progression of disease.  Project 2: Calcineurin inhibitors are highly effective immunosuppressants used in patients with immune diseases and after transplantation. However, their use is limited by their toxic effects on the kidney and the induction of vascular endothelial dysfunction. Current clinical diagnostic markers are known to be insensitive and to only rise after significant damage has already occurred. The proposed study seeks to establish that the negative effects of the calcineurin inhibitor tacrolimus on kidney and vascular endothelial cells in adult and pediatric patients with nephrotic syndrome and after kidney transplantation are reflected by changes in plasma and urine metabolite and protein pattern changes and that these changes have better sensitivity and specificity compared to markers currently established in the clinic such as creatinine in serum.
Cardiovascular, Metabolism and Endocrinology, Pharmacology and PhysiologyAdults, School Age Children, Young AdultsNo
  
This project is to explore development of and potential treatment of autoimmune diseases. We focus on type 1 diabetes and MS predominantly, but are beginning to study the role of autoimmunity in atherosclerosis and cardio-vascular disease. We do translational and reverse translational work. That is, we study how immune cells work in mice and identify the counterparts in human subjects, including autoimmune subjects. We also explore human disease states and determine if we can reverse translate to create appropriate mouse models for further study. The lab has generated a unique drug to control autoimmune inflammation and we are exploring how this drug may translate to T1D, MS and CVD.
Cardiovascular, Immunology and Autoimmune DiseasesNo
  
Hematology and OncologyNo
  
Olfactory disturbances are early symptoms of many neurodegenerative diseases. Our lab examines the circuitry underlying cholinergic modulation of olfactory discrimination. We examine the cross-talk between dopaminergic, GABAergic, and cholinergic neurons in the bulb and basal forebrain.
Neuroscience, Brain and Behavior - Adult, Pharmacology and PhysiologyNo
  
A small number of studies have suggested that, like adults, youth with anxiety disorders experience strikingly elevated rates of sleep problems, particularly insomnia. However, little is known about how insomnia impacts the clinical expression of anxiety disorders or the underlying neural abnormalities implicated in anxiety. This is a critical issue, because if insomnia is found to be a causal or maintaining factor in anxiety, it becomes an important target for the treatment of anxiety. Currently, no studies have examined whether the neural abnormalities exhibited by adults or youth with anxiety are associated with sleep loss. The current study seeks to identify the neural system abnormalities at the core of generalized anxiety disorder (GAD), and examine their relationships with sleep. It employs samples of adolescents with and without GAD, and pairs naturalistic, objective measurement of sleep with functional neuroimaging assessment of the neural circuitry involved in threat reactivity and attentional control.
Developmental Neuroscience, Brain and Behavior - childAdolescentsNo
  
Gliomas are the most aggressive brain tumors, with glioblastoma multiforme (GBM) being the deadliest among them (the average of 6 months survival after diagnosis). These fast growing tumors usually cannot be cured. Magnetic resonance imaging (MRI) is the standard-of-care method to diagnose these tumors. Prior to treatment MRI provides superior detection, localization, and tumor visualization. Immediately after treatment - consisting of surgical resection, radiation treatment (RT) and chemotherapy - MRI cannot be used to assess the residual glioma because the treatment alone induce "abnormal" scans due to inflammation and surgical intervention. This radiological occurrence is called “pseudo-progression” (PsP). PsP causes MRI abnormaities (mimicking tumor progression) up to 12 weeks after completion of treatment. To achieve the best possible prognosis for glioma patients there is urgent need for noninvasive radiological discrimination of PsP vs true progression within these 12 weeks. We have shown, with both in vitro and animal studies, that glioma tumor cells have high amino acid up-take, while inflammatory cells have high iron up-take. The goal of this study is to evaluate noninvasive imaging in mouse glioma models utilizing (i) radioactive amino acids by positron emission tomography (PET) to detect early onset of tumor progression; and (ii) iron-based contrast by MRI to selectively image sites of inflammation due to treatment. This PET/MRI approach should reveal the molecular differences of progression and PsP which can be readily translated to humans. Swift detection of recurrence will allow for time critical decisions regarding additional therapeutic interventions in cases of progression potentially improving overall survival.
Hematology and Oncology, Neuroscience, Brain and Behavior - AdultAnimal Models, ImagingCancer, Neurological IllnessAnesthesiology12631 East 17th Ave AO1, L15-2015 Aurora, CO 80045303 724 1086Natalie.Serkova@UCDenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/centers/cancercenter/Research/sharedresources/AnimalImaging/Pages/AnimalImaging.aspxSerkova, NatalieAnesthesiology, Cancer CenterCurrentNo7/30/2015 9:30 PM
  
The mission of our NIH funded laboratory (The Translational PharmacoNutrition Pharmacology Laboratory (TPN Lab) is to discover and develop the use of new therapeutic agents to improve outcomes from acute illness, injury, and surgery. This research spans the entire range of translational pharmacology (from basic mechanistic pathway determination in cellular/animal systems to large multi-center randomized controlled clinical trials).   Currently, we have a major research focus on the use of nutrition, including specific nutrients  (glutamine and other sports and performance-enhancing nutrients) and probiotics/microbiome interventions as therapeutic agents in improving outcomes from surgery, critical illness, trauma, burn, organ injury, and peri-operative stress. Other areas of interest for our research group include development of coordinated peri-operative interventions (exercise, nutrition, etc.) to improve surgical and burn outcomes.  A student in our fast paced and diverse lab group would be encouraged to develop an independent sub-project within our areas of interest, work on a sub-project of our ongoing clinical trials or select a personalized basic (cellular/animal) science project that would become their own project. The project would be chosen with the intent to lead to publication of abstracts, manuscripts, and presentation at national and international meetings. The student could expect to not only acquire fundamental research skills, but also extensive training in literature research, abstract/paper writing, and oral presentation skills.
SurgeryClinical Trials, NutritionBasic Human Processes, StressAnesthesiologyUniversity of Colorado School of Medicine 12700 E. 19th Ave. Box 8602, RC2 P15-7120 | Aurora, CO 80045303-724-4747Paul.Wischmeyer@ucdenver.eduWischmeyer, PaulCancer CenterCurrentYes8/4/2015 9:02 AM
  
50-80% of our body immune cells reside at our mucosal tissues. In particular our intestines are in a constant state of immune activation as they regulate the food and bacterial contents of our guts while maintaining physiologic function. This immune tolerance; is broken during the development of the autoimmune diseases such as Inflammatory Bowel Disease (IBD; namely, Crohn's disease and Ulcerative Colitis). We principally focus on dissecting the roles that cytokine, chemokine and miRNA networks play in regulating intestinal tolerance versus the progression to IBD. A central theme is to identify innovative approaches to target the break in mucosal immune tolerance, which drives pathogenic CD4+ Helper T cell subsets. Our ultimate goal is to translate our preclinical research into new therapeutic modalities for patients with IBD.
Immunology and Autoimmune DiseasesAnimal Models, Cell Biology, Molecular Biology, and Genetics, Imaging, Light MicroscopyGastrointestinal Disease, Immune Related DiseaseAnesthesiologyOffice # 7118, Research Center 2, Anschutz Medical Campus3037241762eoin.mcnamee@ucdenver.eduhttp://profiles.ucdenver.edu/display/226064McNamee, Eoin (*Owen)AnesthesiologyCurrentNo8/21/2015 12:32 PM
  
The inhibitors of the mammalian target of rapamycin (mTOR) pathway are proliferation inhibitors and as such used as immunosuppressants in transplantation, as anticancer agents and on drug-eluting coronary stents. Clinically used mTOR inhibotors are Sirolimus, Everolimus and Zotarolimus. These have a very complex drug metabolism with many of these metabolites raching significant concentrations in blood. Interestingly, the anti-proliferative and other biological activities of these metabolites are mostly unknown. This project will isolate the major metabolites. Their structures will be identified and their biological activities will be tested.
Cardiovascular, Immunology and Autoimmune Diseases, Pharmacology and PhysiologyBiomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and GeneticsCancer, Heart DiseaseAnesthesiologyBioscience 2, Suite 200 12705 East Montview Boulevard Aurora, CO 80045-7109303-7245-665uwe.christians@ucdenver.eduhttp://www.bioanalytics.usChristians, UweAnesthesiologyCurrentNo8/21/2015 6:17 PM
  
Inflammatory bowel disease (IBD) affects approximately 1.6 million people in the USA. These chronic illnesses are characterized by loss of intestinal epithelial cell integrity and pathogenic CD4T cell accumulation in the inflamed intestine. This project seeks to investigate how proteins produced at the epithelial cell surface regulate intestinal epithelial barrier function and the recruitment of pathogenic CD4T cells to the intestine. In vitro cell culture models and mouse models of intestinal inflammation will be used to study these processes.
Immunology and Autoimmune DiseasesAdultsAnimal Models, Cell Biology, Molecular Biology, and GeneticsGastrointestinal Disease, Immune Related DiseaseAnesthesiology12700 E 19th Avenue RC-2303-724-6245carol.aherne@ucdenver.eduhttps://profiles.ucdenver.edu/display/226074Aherne, CarolAnesthesiologyCurrentNo8/24/2015 11:15 AM
  
Project 1. Our preliminary studies have shown that inflammation, oxidative stress, and endothelial dysfunction are evident in patients with chronic kidney dysfunction (CKD). At the current time, there is an immediate need for specific and sensitive biomarkers that can predict disease progression and stratify patients to those at risk to progress faster. With no approved treatment, control of hypertension and management of secondary features of chronic renal insufficiency are present clinical measures to slow the progression of disease.  Project 2: Calcineurin inhibitors are highly effective immunosuppressants used in patients with immune diseases and after transplantation. However, their use is limited by their toxic effects on the kidney and the induction of vascular endothelial dysfunction. Current clinical diagnostic markers are known to be insensitive and to only rise after significant damage has already occurred. The proposed study seeks to establish that the negative effects of the calcineurin inhibitor tacrolimus on kidney and vascular endothelial cells in adult and pediatric patients with nephrotic syndrome and after kidney transplantation are reflected by changes in plasma and urine metabolite and protein pattern changes and that these changes have better sensitivity and specificity compared to markers currently established in the clinic such as creatinine in serum.
Cardiovascular, Metabolism and Endocrinology, Pharmacology and PhysiologyAdults, School Age Children, Young AdultsBiomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and Genetics, Clinical TrialsKidney, Bladder, and Urethral Disease, Liver DiseaseAnesthesiologyBioscience II Building 12705 E Montview Blvd, Suite 200, Room 2304 Aurora, CO, 80045303-724-5669Jelena.Klawitter@ucdenver.eduKlawitter, JalenaAnesthesiologyCurrentNo8/26/2015 1:03 PM
  
Our studies investigate how modulation of T-type calcium channels in peripheral sensory and CNS neurons affects their function and how different anesthetic and analgesic agents selectively target particular classes of voltage-gated ion channels. In particular, we are interested in testing new selective T-type channel blockers such as neuroactive steroids using functional studies of nociception and anesthetic end points in vivo. In these studies we will use mice lacking particular isoforms of T-type calcium channels, namely CaV3.1, Cav3.2 and Cav3.3 and our established animal models of painful diabetic neuropathy.
Neuroscience, Brain and Behavior - Adult, Pharmacology and PhysiologyAnimal Models, BehavioralDiabetes, PainAnesthesiologyroom L18-4100 RC1 south303-724-9122slobodan.todorovic@ucdenver.eduTodorovic, SlobodanAnesthesiologyCurrentNo5/25/2016 9:45
  
Countless basic science studies have shown that animals exposed to anesthesia during early development exhibit long-term changes in both behavior and cognition, a process known as anesthesia-induced developmental neurotoxicity.  In addition to clinical research investigating the effects of anesthesia on children, basic research focused on identifying the mechanisms behind anesthesia-induced neurotoxicity are necessary for patient safety.  Microglia are the immune cells of the brain, but during early development they are also important for promoting and supporting neurons to ensure normal brain development.  No prior studies have directly investigated the effect of anesthesia on microglia.  Therefore, we utilize sevoflurane, a common anesthetic used in children, and study its effect on microglial development in a neonatal animal model.  Utilizing advanced techniques in immunology and microscopy, we characterize microglial morphology and function after anesthesia and evaluate for microglial-dependent mechanisms of anesthesia-induced developmental neurotoxicity.
Developmental Neuroscience, Brain and Behavior - childAnimal Models, Behavioral, Cell Biology, Molecular Biology, and Genetics, Light Microscopy, NeuroimagingMental Illness and Developmental Disabilities, Neurological IllnessAnesthesiologyRC 1 South, Rm 4101303-724-9053christine.zanghi@ucdenver.eduZanghi, ChristineAnesthesiologyCurrentNo5/25/2016 14:18
  
Patients who receive femoral nerve catheter with single injection sciatic nerve block will have lower post-operative pain scores at 24, 48 and 72 hours than patients who receive femoral nerve catheter alone. Background and Significance: The proposed project will seek to determine a gold-standard method of pain management after anterior cruciate ligament (ACL) reconstruction in the pediatric population. ACL ruptures are a common injury among young patients. Approximately 17.97 ACL reconstruction procedures per 100,000 person-years are performed in patients younger than 20 in the United States each year. Despite advancements in minimally invasive arthroscopic surgical approaches, postoperative pain following ACL reconstruction remains a concern. Regional anesthesia is increasingly employed as an adjunct to general anesthesia during outpatient orthopaedic procedures. A recent systematic review of 75 Randomized Controlled Trials (RCTs) found that regional anesthesia blocks generally decreased postoperative pain following ACL reconstruction. However, only 1 of these 75 studies considered the effects of regional anesthesia on the pediatric population. Moreover, it has been found that pediatric patients report greater pain and anxiety than adults 24 hours after ACL surgery. Thus, the efficacy of regional anesthesia on the pediatric population remains unclear. This study will seek to establish FNC or FNC+SNB as the gold-standard for perioperative pain management of pediatric patients undergoing ACL reconstruction. Methods: Study design - A prospective RCT will be used to determine the efficacy of regional anesthesia on postoperative pain management in the pediatric population following ACL reconstruction. The RCT will be comprised of two arms: FNC or FNC+SNB The primary aim of the study is to determine if patients who receive femoral nerve catheter with single injection sciatic nerve block will have lower pain scores than patients who receive femoral nerve catheter alone. Secondary aims include comparing total rescue pain medication administered and patient satisfaction between the two groups. The procedure will be performed by a sports medicine surgeon and an anesthesiologist at Children’s Hospital Colorado. Data will be collected for pediatric patients (ages 8-18) undergoing ACL reconstruction.
Bone or SkeletalAdolescents, School Age ChildrenClinical Trials, Surveys, Questionnaires, and Psychological TestingBone or SkeletalAnesthesiology13123 E. 16th Ave. 720-777-4587tessa.mandler@childrenscolorado.orgMandler, TessaAnesthesiologyCurrentNo11/11/2016 16:29
  
Developmental Neuroscience, Brain and Behavior - child, Neuroscience, Brain and Behavior - AdultAdults, School Age ChildrenAnimal Models, Behavioral, Cell Biology, Molecular Biology, and GeneticsAgingAnesthesiologyMailstop: 8321; 12800 E. 19th Ave., Aurora CO 80045303-724-6628paco.herson@ucdenver.eduHerson, PacoAnesthesiology, PharmacologyCurrentNo
  
 
 ​Please see Kieft Lab Website for descriptions of the many projects going on in the lab. http://www.medschool.ucdenver.edu/KieftLab
Microbiology and Infectious DiseasesBiomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and GeneticsBiochemistry and Molecular Genetics12801 East 17th Ave, Research 1 South303-724-3257jeffrey.kieft@ucdenver.eduhttp://www.medschool.ucdenver.edu/KieftLabKieft, JeffreyBiochemistry and Molecular GeneticsClosedNo
  
Deletion or mutations of the survival motor neuron (SMN) gene 1 leads to pathogenesis of spinal muscular atrophy (SMA), the leading genetic cause for infant death. Studies have shown that SMA is caused by low protein levels of SMN, but the disease pathogenesis is unknown. My group is interested in the study of biological functions of SMN.
Neuroscience, Brain and Behavior - AdultBiomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and GeneticsNeurological IllnessBiochemistry and Molecular GeneticsL18-9101303-724-3208Changwei.liu@ucdenver.eduLiu, ChangweiBiochemistry and Molecular GeneticsCurrentNo8/18/2015 10:13 AM
  
The momentous discovery of the interleukin(IL)-1 family that induce inflammation revolutionized our understanding of cancer over three decades ago, yet a relatively new IL-1 family member, called IL-37, actually downregulates inflammation and represents an exciting new frontier under investigation here. IL-37 both blocks the pro-inflammatory activity of IL-18 by competing for the IL-18Rα receptor, but IL-37 is also proposed to signal through a co-receptor, TIR8, via the IL-37/IL-18Rα/TIR8 ternary complex.  This dual mechanism of IL-37 activities makes IL-37 a potent anti-inflammatory molecule and, considering the clinical success of IL-1 family thus far, IL-37 itself be an idea candidate for a newly developed therapeutic that blocks multiple inflammatory disorders, including cancer.  Our novel approach combines biochemical, biophysical, and biological studies to address the particular active forms of IL-37 (Aim 1) and then reveal how IL-37 interacts with its receptors (Aim 2).   In Aim 1, we will determine the minimum IL-37 sequence responsible for its anti-inflammatory activities as well as compare the activities of the biologically found forms. To this end, we have developed a novel recombinant expression system that allows for the production of milligram quantities of IL-37 and will be used to produce a series of IL-37 constructs. The structural integrities of these proposed IL-37 constructs will be assessed by Nuclear Magnetic Resonance and their anti-inflammatory activities will be quantified using cell-based assays that monitor both downstream signaling and phenotypical changes.  In Aim 2, we will characterize the binding of IL-37 to both IL-18Rα and TIR8. Both biochemical and biophysical experiments will be used to define the interactions of IL-37 constructs and its receptors, thereby determining their respective affinities and the sequence of binding events. Already, mammalian and bacterial expression systems are in place for both IL-18Rα and TIR8, respectively, along with preliminary results that confirm our recombinant proteins interact tightly.
Hematology and Oncology, Immunology and Autoimmune DiseasesBiomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and GeneticsCancer, Immune Related DiseaseBiochemistry and Molecular GeneticsRC-1 South 9-117917-572-2649Elan.Eisenmesser@ucdenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/departments/biochemistry/Faculty/PrimaryFaculty/Pages/Eisenmesser.aspxEisenmesser, ElanCancer CenterCurrentYes8/18/2015 10:16 AM
  
We are a highly collaborative group that has a range of projects to use or advance diagnostic technologies for patient stratification and to understand molecular mechanisms involved in disease progression.  We are currently working to understand metabolic and tissue microenviroment alterations in cancer, bleeding disorders in trauma and shock, and scaffold requirements for tissue engineering.
Cardiovascular, Hematology and Oncology, Metabolism and Endocrinology, Pharmacology and Physiology, SurgeryAdolescents, AdultsAnimal Models, Biomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and Genetics, Clinical TrialsBiochemistry and Molecular GeneticsRC1-S room 9120303-724-5544kirk.hansen@ucdenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/departments/biochemistry/Research/researchlabs/HansenLab/Pages/HansenLab.aspxHansen, KirkBiochemistry and Molecular GeneticsCurrentNo8/18/2015 11:29 AM
  
Projects in the lab will focus on developing new molecular methods for studying DNA damage and repair, and will have a large computational component. Note that a computational background is not necessary; several MSTP students have already taken on such projects, most with minimal coding experience.
Basic ProcessesCell Biology, Molecular Biology, and GeneticsBasic Human ProcessesBiochemistry and Molecular GeneticsRC1 South 10104303-724-5384jay.hesselberth@gmail.comhttp://hesselberthlab.github.ioHesselberth, JayBiochemistry and Molecular GeneticsCurrentYes5/8/2016 14:11
  
The project will involve using cutting edge genome technologies to address questions related to human cognitive disease and brain evolution. The project will focus on the role of DUF1220, a protein domain which shows the greatest human specific copy number increase of any coding regions in the genome. The work will build upon previous studies from our lab that have linked DUF1220 to brain evolution, schizophrenia and autism.
Developmental Neuroscience, Brain and Behavior - child, Neuroscience, Brain and Behavior - AdultBiomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and GeneticsMental Illness and Developmental DisabilitiesBiochemistry and Molecular GeneticsRC1 South, Room 10125303-724-3385james.sikela@ucdenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/departments/biochemistry/Research/researchlabs/sikelalab/Pages/default.aspxSikela, JamesBiochemistry and Molecular GeneticsCurrentNo5/11/2016 10:11
  
Dr. Britt studies photoreceptor cell-fate determination and the regulation of visual pigment gene expression in Drosophila.  The compound of eye of Drosophila is highly patterned and has been used extensively as a model system in developmental biology. His laboratory has found that the cell fate and visual pigment expression pattern of adjacent photoreceptor cells is tightly coordinated. It appears that one retinal cell type in the eye adopts one of two different cell fates in a stochastic (random) manner, and then communicates this decision (inductively) to the adjacent photoreceptor cell. These events coordinate the expression of the visual pigments in these two cells, and produce two types of optical units within the eye that have distinct color sensitivities. To examine this process at a genetic and molecular level, his laboratory has identified a collection of mutants that have a variety of defects in eye development. These mutants define genes that are required for the normal patterning of the eye. One group of mutants shows defects in the stochastic determination event, and another group has defects in the inductive signal between adjacent cells. They are currently characterizing these mutations and beginning the molecular analysis of the affected genes.
 The Britt lab is also examining how the structures of different visual pigments regulate their color sensitivity. They have identified specific amino acid residues that are responsible for regulating UV vs. visible and blue vs. green sensitivity. Interestingly, these same amino acid sites in human and other vertebrate visual pigments are also responsible for tuning color sensitivity. Mutations at these sites may also lead to inherited forms of blindness. In addition, these same amino acid sites in human neurotransmitter receptors regulate the binding of transmitters and drugs as well as receptor activation.
 
Vision SciencesAnimal Models, Biomolecular Structure and Biochemistry, Cell Biology, Molecular Biology, and GeneticsEye DiseaseCell and Developmental BiologyResearch Complex I South, Room 12100303-724-3441Steve.Britt@UCDenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/departments/CellDevelopmentalBiology/facultyresearch/Pages/SteveBritt.aspxBritt, Steven G.Cell and Developmental BiologyCurrentNo1/1/2015
  
Developing a drug delivery system of packaging drugs inside pefluorocarbon microbubbles for intrapulmonary delivery to treat high altitude induced pulmonary vasoconstriction  
Cardiovascular, Immunology and Autoimmune Diseases, Pharmacology and Physiology, Pulmonary and Critical CareAdults, Infants, Men, Women, Young AdultsAnimal Models, Cell Biology, Molecular Biology, and GeneticsKidney, Bladder, and Urethral Disease, Lung Disease, StressCell and Developmental Biology12, 700 E 19th Ave Research building 2 Aurora CO 80045303 724-3684David.irwin@ucdenver.eduIrwin, DavidCancer CenterCurrentYes8/14/2015 2:27 PM
  
There are different projects in the laboratory raging from basic studies of brain function in mice to studies in human brain and human olfactory epithelium. We also develop novel devices to image the brain in animal and human applications. Which of the projects are available depends on which individual in the lab is available for mentoring the medical student.
Neuroscience, Brain and Behavior - AdultAnimal Models, Behavioral, Cell Biology, Molecular Biology, and Genetics, Electrophysiology, Imaging, Light Microscopy, NeuroimagingMental Illness and Developmental Disabilities, Multiple Sclerosis, Neurological IllnessCell and Developmental BiologyUniversity of Colorado Anschutz Medical Campus Department of Cell and Developmental Biology MS 8108 Bldg RC1 South, Room L18-11119 12801 E 17th Ave Aurora, CO 80045303-724-3405diego.restrepo@ucdenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/centers/tastesmell/Pages/DRestrepoLab.aspxRestrepo, DiegoCell and Developmental Biology, OtolaryngologyCurrentNo8/20/2015 2:52 PM
  
Hematology and OncologyAnimal Models, Behavioral, Biomolecular Structure and Biochemistry, Electrophysiology, Imaging, Talking and Behavior TherapiesCancer, Neurological IllnessCell and Developmental BiologyRm 11121 RC1 South AMC303-724-3438linda.barlow@ucdenver.eduBarlow, LindaCancer CenterCurrentNo8/24/2015 10:46 AM
  
Melanoma is a heterogeneous disease with a wide variety of clinical presentations, including superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, acral lentiginous melanoma, and ocular melanoma, among others. About 6.5% of new melanomas appear in the third decade of life, with numbers of new cases peaking after 50 years of age. Similarly, melanoma may appear in any location on the skin’s surface, in chronically sun exposed sites, and in sites that see very little sun. While the majority of melanomas are detected as early stage disease, almost 10,000 people die from metastatic disease every year in the USA. At present there is very little understanding of the factors that may contribute to regulate the clinical presentation of melanoma. Melanoma is known to result from exposure to ultraviolet (UV) light that induces mutations in key oncogenes and tumor suppressor genes. Genetic risk factors also play a role in predisposing individuals to melanoma. At present there are many genetic loci that have been implicated in melanoma risk.  We hypothesize that UV exposure history interacts with inherited genetic risk factors and with the somatic mutations within each cancer to impact the clinical presentation of melanoma.  This student project will set up the methods to collect clinical data on melanoma patients, together with samples for genetic analysis and a UV camera assessment of skin sun damage will be performed. A subset of the collected data will be analyzed to determine the interaction between sun damage, melanoma risk genotype and age of onset of melanoma.
Hematology and OncologyCell Biology, Molecular Biology, and Genetics, Chart ReviewCancerDermatologyDepartment of Dermatology/Stem Cell Biology RC1-N, P18-8132 12800 E. 19th Avenue Aurora, CO, 800453037240160Neil.Box@ucdenver.eduhttp://www.ucdenver.edu/academics/colleges/medicalschool/centers/StemCell/Faculty/Pages/Box,%20Neil.aspxBox, NeilCancer CenterCurrentYes8/20/2014
  
Aim 1: To determine feasibility of administering the three opioid risk screening tools in the emergency department (ED): Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R), Drug Abuse Screening Test (DAST) and Opioid Risk Tool (ORT). Hypothesis 1: Patients will be able to complete the screening tools without difficulty, but with various levels of time required for completion. Aim 2: To determine if the screening tools are predictive of Aberrant Drug-Related Behavior (ADB), defined as opioid prescriptions from 4 or more clinicians during the preceding 6 months in the statewide prescription drug monitoring program. Hypothesis 2: All three tools will be predictive of ADB, but with varying levels of sensitivity and specificity. We believe that one of the tools will emerge as performing the best in the ED environment.
Health Care and Public Health Research, Neuroscience, Brain and Behavior - AdultSurveys, Questionnaires, and Psychological TestingDrug AbuseEmergency MedicineB215720-848-6769jason.hoppe@ucdenver.eduHoppe, JasonSubstance Use Disorders GrantCurrentNo1/18/2016
  
 
 ​Ongoing work through a variety of projects to improve the delivery of evidence based care within community and rural primary care practices.
Health Care and Public Health ResearchAdolescents, AdultsSurveys, Questionnaires, and Psychological TestingCancer, Skin DiseaseFamily Medicine12631 East 17th Avenue, Room 3512303-724-1839donald.nease@ucdenver.eduNease, DonaldFamily MedicineCurrentNo6/20/2013 7:31 PM
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