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Title

Etiology of gastrointestinal disease in children

Status

Open

Project Description

Acute gastrointestinal disease is one of the leading causes of mortality in children worldwide.  Recently, several new viruses have been discovered that have been associated with gastroenteritis in children.  In particular, several new human coronaviruses (HCoV-NL63 and HCoV-HKU1) have been found in children with diarrhea.  Other emerging viruses that have been linked with childhood gastrointestinal disease include noroviruses, astroviruses, bocaviruses, and novel enteroviruses.  My laboratory is looking at the prevalence and disease association of these viruses in pediatric patients with gastroenteritis admitted to The Children’s Hospital, Aurora, CO.   Stool specimens will be screened by qRT-PCR to look for the presence of CoV RNA and other viral pathogens and medical charts of positive samples will be reviewed.  Overall, we plan to collect and test approximately 500-1,000 stool specimens submitted for testing and found to be negative for other known viral causes of pediatric gastroenteritis.  Additionally, using next generation sequencing technology we are looking for novel pathogens associated with gastroenteritis in children.

Mentor Name

Dominguez, Samuel

Mentor Location

TCH B055, 13123 E 16th Ave, Aurora CO 80045

Mentor Contact Number

303-724-4236

Mentor Contact Email

Samuel.dominguez@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Pediatrics

Funding Department/Program

Pediatrics

Area of Study

Microbiology and Infectious Diseases

Populations

Adolescents; Infants; School-age Children

Method(s)

Cell Biology, Molecular Biology, and Genetics; Chart Review

Disease or Symptom

Gastrointestinal Disease; Infection

Faculty/Lab Website

 

Display on public listings?

Yes

Attachments

Created at 10/28/2010 8:26 AM by Vetter, Stephanie
Last modified at 7/9/2013 2:02 PM by Watts, Katie