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Drugs Development Using Animal Models of Schizophrenia: Physiology and Pharmacology     



Project Description

This project will attempt to gain a better understanding of the underlying mechanisms of sensory inhibition deficits
Sensory inhibition deficits are commonly observed in schizophrenia and are thought to be related to certain cognitive problems and to hallucinations. Similar deficits have been found to occur spontaneously, or can be created via certain manipulations, in rodents. Using rodent models, we are attempting to identify the mechanism(s) underlying the deficit. We are also involved in the development of new drugs to treat the deficit. The primary method employed is electrophysiological recording of auditory evoked potentials, both acutely in anesthetized mice and in chronically implanted, awake and behaving rats. Current projects include investigation of new drugs, permanent correction of the deficit through gestational interventions, and studies of neurotransmitter receptor involvement through alteration of receptor levels via mRNA manipulations.

Mentor Name

Stevens, Karen

Mentor Location

Research Complex I

Mentor Contact Number


Mentor Contact Email   


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Preceptor Name






Funding Department/Program

Psychiatry and Developmental Neuroscience

Area of Study

Developmental Neuroscience, Brain and Behavior - Child; Neuroscience, Brain and Behavior - Adult; Pharmacology and Physiology




Animal Models

Disease or Symptom

Mental Illness and Developmental Disabilities

Faculty/Lab Website


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Created at 9/3/2010 9:52 AM by Vetter, Stephanie
Last modified at 7/31/2013 1:04 PM by Watts, Katie