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Title

Etiology and Pathogenesis of Systemic Lupus Erythematosus

Status

Open

Project Description

 

Lupus is an autoimmune disease that affects primarily women during their childbearing years and can be devastating.  The cause is not known although both genetic and environmental factors are believed to be important.  One project in my lab is directed at understanding the cause of lupus by examining genes that are likely involved in its development.  One gene that we are particularly interested in is complement receptor 2, which is decreased in patients with lupus and which contains several polymorphisms that are associated with disease.  We are aiming to understand the functional effect of these polymorphisms at the molecular, cellular and system level, using both animal models and human samples.  Another project involves the identification of biomarkers that either predict the development of lupus in predisposed individuals or that predict flares of disease in patients with already diagnosed lupus.  A third project involves the development of therapies that will tolerize autoreactive B cells and prevent the development or progression of lupus using animal models.  We believe that better understanding of the mechanisms that underpin the development of lupus with lead to more effective and less toxic therapies. 

 

Mentor Name

Boackle, Susan

Mentor Location

1775 Aurora Court, Room 3102B

Mentor Contact Number

303-724-7611

Mentor Contact Email

susan.boackle@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Rheumatology Grant

Area of Study

Immunology and Autoimmune Diseases

Populations

Adults

Method(s)

Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Arthritis; Heart Disease; Lung Disease; Neurological Illness

Faculty/Lab Website

http://www.cudoctors.com/find-a-doctor/?keywords=boackle

Display on public listings?

Yes

Attachments

Created at 7/3/2012 12:24 PM by Watts, Katie
Last modified at 8/23/2012 11:31 AM by Watts, Katie