This 10 week interdisciplinary course in the Fall semester integrates clinical and basic science topics related to the normal function and diseases of the gastrointestinal and endocrine systems. The biochemistry and physiology of nutrient metabolism in health and disease will also be covered.
John Tentler, PhD
Virginia Sarapura, MD
Daniel Bessesen, MD
Ellen Valentine (303-724-2069)
- Describe the normal gross structure, histology and physiology of the digestive organs (salivary glands, esophagus,
stomach, small bowel, colon, gall bladder, exocrine pancreas, and liver) and endocrine organs (endocrine pancreas,
hypothalamus, pituitary, adrenal, thyroid and parathyroid glands).
- Discuss the key biochemical regulatory steps in the metabolism of carbohydrates, fats and amino acids, and their role in
maintaining the body’s energy balance.
- Discuss the normal nutritional requirements of the body and how energy imbalance can result in common diseases and
clinical conditions such as obesity, diabetes, hyperlipidemia and osteoporosis.
- Describe the causes (genetic, developmental, microbiologic, autoimmune, metabolic, toxic and traumatic) of digestive,
metabolic and endocrine dysfunction.
- Describe the altered structure (pathology) and function (pathophysiology) of digestive and endocrine organs as seen in
common diseases and clinical conditions.
- Apply the principles of pharmacology, therapeutics and therapeutic decision‐making to digestive, endocrine and
- Discuss how the principles of genomics, proteomics and bioinformatics can be used to better understand health and
dysfunction of the digestive, metabolic and endocrine systems.
- Discuss the scientific principles and limitations of laboratory and radiologic diagnostic methods in the diagnosis of
digestive, metabolic and endocrine dysfunction.