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Department of Psychiatry

Department of Psychology

 Susan K. Mikulich-Gilbertson, PhD

Susan K. Mikulich-Gilbertson, PhD

Recent Publications


Susan Mikulich-Gilbertson, PhD

Associate Professor



Positions and Employment:

1990-1993     Professional  Research Assistant, (ARTS), Director of Data Management & Analysis, (ARTS)     

1994-1997     Senior Professional Research Asst, (ARTS), Director of Data Management & Analysis, (ARTS)

1997-2000     Instructor, University of Colorado School of Medicine, Department of Psychiatry

Director of Biometrics and Informatics for Clinical Research, ARTS

2001-2008     Assistant Professor, University of Colorado Health Sciences Center, Department of Psychiatry, Primary Appointment,  Director of Biostatistics, Division of Substance Dependence Department of Preventive Medicine and Biometrics, Secondary Appointment

2008-present     Associate Professor, University of Colorado Denver, Department of Psychiatry, Primary Appointment, Director of Biostatistics, Division of Substance Dependence Department of Preventive Medicine and Biometrics, Secondary Appointment


2009     Drug and Alcohol Dependence Award for Top 10 Cited Paper during 2006-2008

2004     National Institute on Drug Abuse (NIDA) Women and Gender Junior Investigator Travel Award for the CPDD meeting in San Juan Puerto Rico

2002     7th Annual University of Colorado Health Sciences Center Department of Psychiatry Junior Faculty Poster Session:  1st Place in Basic Science Research

2001     College on Problems of Drug Dependence Early Investigator Award

2000     Outstanding Doctoral Biometrics Graduate Student: Strother S. Walker Award

1997     University of Colorado Health Sciences Center Graduate School Doctoral Fellowship

1997     International Biometric Society Western North American Region Student Paper Competition:  1st Place in Oral Presentation

1996     Outstanding Master’s Biometrics Graduate Student: Maurice Davies Award

1989     Graduated Summa Cum Laude: Neuropsychology and Psychology

1989     Graduated with Distinction and Honors in Liberal Arts:  Bachelor’s degree





Course Title

Course Description

Winter Qtr


Biometrics 6632

Statistical Theory II

The second in a three-quarter sequence in mathematical statistics for M.S. students in Biometrics

Winter Qtr


Biometrics 6612

Computer Oriented Statistical Methods II

Part of an accelerated three-quarter applied statistics sequence designed to familiarize graduate students with the quantitative

Winter Qtr


Biometrics 6612

Computer Oriented Statistical Methods II

methods most frequently used in medical research

Fall Qtr


Biometrics 6611

Computer Oriented Statistical Methods I

Part of an accelerated applied statistics sequence for graduate students emphasizing methods for medical research

Fall Sem


Biometrics 6621

Statistical Consulting,

Guest Lecture

Gave lecture on 9/25/2007 on the paper submission and journal review process as part of the Statistical Consulting class

Selected Lectures, Seminars, and Grand Rounds for Students, Residents, Fellows, Peers:

May 2003     Analyzing Data from Multi-Center Trials: The Clinical Trials Network.  Seminar for the Division of Substance Dependence, Department of Psychiatry, UCHSC, Denver Colorado

January 2004     Gender Differences in the Course of Antisocial Behavior Among Injection Drug Users. Presented as part of the “Festschrift in Substance Use” Grand Rounds, Department of Psychiatry, UCHSC, Denver Colorado

March 2004     Handling "Site" in the Statistical Analyses of Multi-site Clinical Trials. SeminarSeries: Methods and Applications in Health Outcomes Research.  Sponsored by Colorado Health Outcomes Program (COHO)/UCHSC and the Clinical Research Unit/Kaiser Permanente of Colorado, Aurora Colorado

December 2004     Multisite Clinical Trials:  Design and Analyses Make a Difference. Grand Rounds, Department of Psychiatry, UCHSC, Denver Colorado

April 2006     “Site” specification in a Multisite Clinical Trial of Motivational Incentives for Stimulant Users: Fixed or Random?  Biostatistics Seminar Series Spring 2006, Department of Preventive Medicine and Biometrics, UCHSC, Denver Colorado

October 2007     HIV and HCV Risk Reduction Interventions in Drug Detoxification and Treatment Settings:  Results from CTN-0017.  Seminar for the Division of Substance Dependence, Department of Psychiatry, UCHSC, Denver Colorado (Co-presenter with Robert Booth, Ph.D.)

January 2010     Achieving Career Success as a Biostatistician with an Outside Primary Appointment. Department of Biometrics/Informatics, University of Colorado School of Public Health, Denver Colorado

Selected Mentorship:

            2000-2001     Carolyn Swenson, M.P.H student, committee member, graduated

            2001-2002     Colleen Ross, M.S. Biometrics, committee member, graduated

            2004-2005     Angi Wold, M.I.S.., Health & Behavioral Sciences, committee member, graduated

            2006–2008     Ann Lazar, Ph.D. Analytic Health Sciences, dissertation chair, graduated

            2006–2008     Elisa Upwood, M.I.S., Health and Behavioral Sciences, thesis mentor, graduated



Active (Selected from 9 grants): 

5R01 DA009842-14     (Crowley)

09/01/95-04/30/11        NIH/NIDA

Substance Dependent Adolescents: Imaging Risk-Taking

The research seeks to understand if substances diminish the capacity to inhibit behavior by altering brain processing of risky decisions, or if pre-existing variations of brain processing produce risk-taking or both.

Role: Co-Investigator and Statistician


5R01 DA018679-03     (Davies)                                                

05/01/06-04/30/10      NIH/NIDA                                               

Martial Arts As Early Intervention for Teen Drug Abuse              

This Stage 1A/1B behavioral therapies development grant seeks to develop a manualized early intervention for adolescent substance abuse (based on traditional martial arts) and then conduct a pilot study.

Role: Co-Investigator, Statistician 


7R01 DA020575-03     (Miech)                                                  

07/20/07-06/30/10      NIH/NIDA                                                       

The Increasing Disparity in Illegal Drug Use Across Socioeconomic Strata

This project uses secondary data analysis to examine why the prevalence of illegal drug use has increased at a significantly faster rate in the lower as compared to the upper social strata in recent decades.

Role: Co-Investigator, Statistician


5R01 CA126971-02     (Laudenslager)



Psychoeducation for BMT Caregivers: Biobehavioral Markers and Outcome

This randomized controlled trial will test the efficacy of a psychoeducational intervention for caregivers of patients undergoing bone marrow transplant.  Outcomes will include psychosocial and biological measures

Role:  Co-Investigator, Statistician


1R01 DA022284-02     (Riggs)                                                  

08/15/08-06/30/13      2.40 Calendar Months   NIH/NIDA                                                                                                                     $452,004

Bupropion for ADHD in Adolescents with Substance Use Disorders

This project will assess the safety and efficacy of bupropion in treating ADHD and in reducing nicotine use in adolescents with ADHD and SUD and will evaluate bupropion’s effect on other drug use and depression.

Role: Co-Investigator, Statistician


2P60 DA011015-11A1     (Hewitt)                                              

05/01/09-02/28/14          NIH/NIDA                                                                                            

Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors

      Core B: Data Management, Informatics, and Biostatistics Core- Mikulich-Gilbertson, Co-PI

      Comp. 3: A Neurogenetic Basis for Risky HIV-Related Decisions- Crowley, PI

This center conducts research in: antisocial drug dependence, human behavioral genetics, HIV Risk Behaviors


Pending (Selected from 6 Pending Grants):

1R01 DA029258-01     (Coors)                                                  

04/01/10-03/31/13                        NIH/NIDA                                                                                

Ethical Issues in Broad Data Sharing for Addiction Research: Best Practices

The proposed research will: (1) identify risks to participants in biobanks; (2) attain insight about how persons with addictions process information and make decisions about enrolling in risky research; (3) make recommendations for informed consent and Institutional Review Boards

Role: Co-Investigator


1R01 DA029579-01     (Mikulich Gilbertson)     

07/01/10-06/30/14      NIH/NIDA                                                                                

Improving the Analyses of Discounting Behavior and Its Relationship to Drug Use

This project aims to demonstrate theoretically and empirically when the two-stage and nonlinear mixed model analytical approaches are similar and when they differ, particularly in the discounting context. 

Role: Principal Investigator

Publications (Selected from 43 peer-reviewed publications)

Dalwani, M., Sakai, J. T., Mikulich-Gilbertson, S. K., Tanabe, J., Raymond, K., McWilliams, S. K., Thompson, L., Banich, M. T., Crowley, T. J. (2011, in press). Reduced cortical gray matter volume in male adolescents with substance and conduct problems. Drug and Alcohol Dependence.

Sakai, J. T., Dalwani, M., Gelhorn, H. L., Mikulich-Gilbertson, S. K., Crowley, T. J. (2010, submitted). Assessing self-oriented vs. other-oriented behavior among adolescents with conduct and substance problems. Journal of Clinical Child and Adolescent Psychology.

Crowley, T. J., Dalwani, M. S., Mikulich-Gilbertson, S. K., Du, Y. P., Lejuez, C. W., Raymond, K. M., Banich, M. T. (2010). Risky Decisions and Their Consequences: Neural Processing by Boys with Antisocial Substance Disorder. PLoS ONE, 5(9), e12835

Laudenslager, M. L., Natvig, C., Mikulich-Gilbertson, S. K., Blevins, M., Corcoran, C., Pierre, P., Bennett, A. J. (2010). Challenges to bonnet monkey (Macaca radiata) social groups: Effects on the mother-infant dyad and infant social interactions. Developmental Psychobiology, 52(5), 465-474.

Thurstone, C., Riggs, P. D., Salomonsen-Sautel, S., Mikulich-Gilbertson, S. K. (2010). Randomized, Controlled Trial of Atomoxetine for Attention-Deficit/Hyperactivity Disorder in Adolescents With Substance Use Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 573-582.

Gelhorn, H., Hartman, C., Sakai, J., Mikulich-Gilbertson, S., Stallings, M., Young, S., Rhee, S. H., Corley, R., Hewitt, J., Hopfer, C., Crowley, T. (2009). An Item Response Theory analysis of DSM-IV Conduct Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 42-50.

Coors, M. E., Mikulich-Gilbertson, S. K., Raymond, K. M., Stover, S. K., Crowley, T. J., Brown, S. A., Tapert, S. F. (2008). Directives for retained DNA: preferences of adolescent patients with substance and conduct problems and their siblings. American Journal of Bioethics, 8, 77-79.

Mikulich-Gilbertson, S. K., Salomonsen-Sautel, S., Sakai, J. T., Booth, R. E. (2007). Gender similarities and differences in antisocial behavioral syndromes among injection drug users. American Journal on Addictions, 16, 372-382.

Riggs, P. D., Mikulich-Gilbertson, S. K., Davies, R. D., Lohman, M., Klein, C., Stover, S. K. (2007). A randomized controlled trial of fluoxetine and cognitive behavioral therapy in adolescents with major depression, behavior problems, and substance use disorders. Archives of Pediatric and Adolescent Medicine, 161(11), 1-9.

Hopfer, C. J., Lessem, J. M., Hartman, C. A., Stallings, M. C., Cherny, S. S., Corley, R. P., Hewitt, J. K., Krauter, K. S., Mikulich-Gilbertson, S. K., Rhee, S. H., Smolen, A., Young, S. E., Crowley, T. J. (2007). A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9. Drug and Alcohol Dependence, 89, 34-41.

Carroll, K. M., Ball, S. A., Nich, C., Martino, S., Frankforter, T. L., Farentinos, C., Kunkel, L. E., Mikulich-Gilbertson, S. K., Morgenstern, J., Obert, J. L., Polcin, D., Snead, N., Woody, G. E. (2006). Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: A multisite effectiveness study. Drug and Alcohol Dependence, 81, 301-312.

Crowley, T. J., Raymond, K. M., Mikulich-Gilbertson, S. K., Thompson, L. L., Lejuez, C. W. (2006). A risk-taking “set” in a novel task among adolescents with serious conduct and substance problems. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 175-183.

Sakai, J. T., Mikulich-Gilbertson, S. K., Long, R. J., Crowley, T. J. (2006). Validity of transdermal alcohol monitoring: Fixed and self-regulated dosing. Alcoholism: Clinical and Experimental Research, 30, 26-33.

Stallings, M. C., Corley, R. P., Dennehey, B., Hewitt, J. K., Krauter, K. S., Lessem, J. M., Mikulich-Gilbertson, S. K., Rhee, S. H., Smolen, A., Young, S. E., Crowley, T. J. (2005). A genome-wide search for quantitative trait loci influencing antisocial drug dependence in adolescence. Archives of General Psychiatry¬, 62, 1042-1051.

Swenson, C. J., Marshall, J. A., Mikulich-Gilbertson, S. K., Baxter, J., Morgenstern, N. (2005). Physical activity in older, rural, Hispanic, and non-Hispanic while adults. Medicine & Science in Sports & Exercise, 37, 995-1002.

Booth, R. E., Mikulich-Gilbertson, S. K., Brewster, J. T., Salomonsen-Sautel, S., Semerik, O. (2004). Predictors of Self-Reported HIV Infection Among Drug Injectors in Ukraine. Journal of Acquired Immune Deficiency Syndrome, 35, 82-88.

Riggs, P. D., Hall, S. K., Mikulich-Gilbertson, S. K., Lohman, M., Kayser, A. (2004). A randomized controlled trial of pemoline for attention deficit hyperactivity disorder in substance abusing adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 43(4), 420-429.

Crowley, T. J., Mikulich, S. K., Ehlers, K., Hall, S., Whitmore, E. A. (2003). Discriminative validity and clinical utility of an abuse-neglect interview for adolescents with conduct and substance use problems. The American Journal of Psychiatry, 160, 1461-1469.

Mikulich, S. K., Zerbe, G. O., Jones, R. H., Crowley, T. J. (2003). Comparing linear and nonlinear mixed model approaches to cosinor analysis. Statistics in Medicine, 22(20), 3195-3211.

Ross, R. G., Olincy, A., Mikulich, S. K., Radant, A. D., Harris, J. G., Waldo, M., Compagnon, N., Heinlein, S., Leonard, S., Zerbe, G. O., Adler, L., Freedman, R. (2002). Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes. Psychophysiology, 39(6), 809-819.

Crowley, T. J., Mikulich, S. K., Ehlers, K. M., Whitmore, E. A., Macdonald, M. J. (2001). Validity of structured clinical evaluations in adolescents with conduct and substance problems. Journal of the American Academy of Child and Adolescent Psychiatry, 40(3), 265-273.

Mikulich, S. K., Hall, S. K., Whitmore, E. A., Crowley, T. J. (2001). Concordance between DSM-III-R and DSM-IV diagnosis of substance use disorders in adolescents. Drug and Alcohol Dependence, 61, 237-248.

Mikulich, S. K., Zerbe, G. O., Jones, R. H., Crowley, T. J. (1999). Relating the classical covariance adjustment techniques of multivariate growth curve models to modern univariate mixed effects models. Biometrics, 55, 957-964.

Crowley, T. J., Mikulich, S. K., Macdonald, M., Young, S. E., Zerbe, G. O. (1998). Substance-dependent, conduct-disordered adolescent males: severity of diagnosis predicts two-year outcome. Drug and Alcohol Dependence, 49, 225-237.

Crowley, T. J., Mikulich, S. K., Williams, E. A., Zerbe, G. O., Ingersoll, N. C. (1992). Cocaine, social behavior, and alcohol-solution drinking in monkeys. Drug and Alcohol Dependence, 29, 205-223.