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Amanda J. Law, PhD

Professor, Dr. Nancy L. Gary Endowed Chair


Contact Info:
Email: Dr. Law
 
Clinical/Research Interests:
Dr. Law’s translational research program focuses on the developmental mechanisms underlying genetic and environmental risk for schizophrenia with the aim of identifying novel biological pathways for treatment development.


University of Sheffield, UK, Bsc. (Hons) - Anatomy and Cell Biology, 1993-1996

University of Sheffield Hallam, UK, MSc. - Human Neurobiology, 1996-1997

University of Manchester, UK, Ph.D. - Neuroscience, 1997-2000

  • Member. Society for Biological Psychiatry, 2006-present
  • Member. Society for Neuroscience, 2006-present
  • Member. American College of Neuropsychopharmacology, 2012-2017
  • American College of Neuropsychopharmacology, Program Committee, 2013-2016
  • Scientific Council Member. Brain and Behavior Research Foundation, 2015-present
  • Society of Biological Psychiatry. Senior Women’s Leadership Group, 2015-present
  • ICOSR, program committee and Young Investigator Selection Committee, 2016
  • Society of Biological Psychiatry. Nominating Committee, 2017-2020
  • American College of Neuropsychopharmacology, Membership Committee, 2017-2020
  • Fellow, American College of Neuropsychopharmacology, 2017-present
Law AJ*; Barbara K. Lipska; Cynthia Shannon Weickert; Thomas M. Hyde; Richard E. Straub; Ryota Hashimoto; Paul J. Harrison; Joel E. Kleinman; Daniel R. Weinberger: Neuregulin 1 (NRG1) Transcripts are differentially expressed in schizophrenia and regulated by 5’ snps associated with the disease . Proc Nat Acad Sci. 2006; 103(17):6747-52. PMCID: PMC1458952

Harrison PJ and Law AJ*: Neuregulin 1 (NRG1) and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry. 2006 Jul 15;60(2):132-40

Law AJ*; Joel E. Kleinman; Daniel R. Weinberger; Cynthia Shannon Weickert: Disease associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice variant expression in the brain in schizophrenia Hum Mol Genet. 2007 Jan 15;16(2):129-41

Mathew SV, Law AJ, Lipska BK, Davila-Garcia MI, Zamora ED, Mitkus SN, Vakkalanka R, Straub RE, Weinberger DR, Kleinman JE, Hyde TM. {alpha}7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in Neuregulin 1. Hum Mol Genet. 2007; 16(23):2921-32.
 
Tan W, Wang Y, Gold B; Chen, J ; Dean M; Harrison PJ; Weinberger DRW and Law AJ*. Molecular cloning of a brain-specific, developmentally regulated Neuregulin 1 isoform and identification of a functional promoter variant associated with schizophrenia.  J Biol Chem. 2007; 282(33):24343-51; 

Nicodemus KK, Law AJ, Luna A, Vakkalanka R, Straub RE, Kleinman JE, Weinberger DR. A 5’ promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression. Mol Psychiatry 2009; 14, 741–743. PMCID: PMC3271936 

Deakin IH, Law AJ, Oliver PL, Schwab MH, Nave KA, Harrison PJ et al. Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice. Neuroreport 2009; 20:1523–1528. PMCID: PMC2880453

W Tan, M Dean and AJ Law*. Molecular cloning and characterization of the human ErbB4 gene: Identification of novel splice isoforms in the developing and adult brain. PLoS One. 2010; 5 (9) e12924. PMCID: PMC2944867

JE Kleinman, AJ. Law, BK. Lipska, TM. Hyde, JK. Ellis, PJ. Harrison and DR. Weinberger. Genetic Neuropathology of Schizophrenia: New Approaches to an Old Question, and New Uses for Post Mortem Human Brains. Biol Psychiatry. 2010; 69(2):140-5. PMCID: PMC4351748

WT Kao; Y Wang; JE. Kleinman; BK. Lipska; TM. Hyde; DR. Weinberger and AJ Law*. Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain. Proc Nat Acad Sci. 2010; Aug 31;107(35):15619-24. PMCID: PMC2932571

T Hyde, B Lipska, T Ali, S Mathew, AJ Law, O Metitiri, R Straub, T Ye, C Colantuoni, M Herman, L Bigelow, D Weinberger, and J Kleinman. Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci. 2011; Jul 27;31(30):11088-95. PMCID: PMC3758549

Marenco S; Geramita M; Willem van der Veen J; Barnett  AS; Kolachana B; Shen J; Weinberger DR and AJ Law.* Genetic association of ErbB4 and Human Cortical GABA levels in-vivo.  J Neurosci. 2011; Aug 10;31(32):11628-32. PMCID: PMC3159177

Deakin IH, Law AJ, Nissen W, Schwab M, Nave K-A, Lamsa K, Paulsen O, Bannerman DM, Harrison PJ.  Transgenic over-expression of the type I isoform of neuregulin 1 (NRG1) affects working memory and hippocampal oscillations but not long term potentiation. Cereb Cortex. 2011 Aug 30. PMCID: PMC3377963

AJ Law*; Y Wang Y; Y Sei; KK Nicodemus; O’Donnell P, Piantadosi P, Papaleo F; Strauba,RE, Huang, W; Thomas CJ, Vakkalankaa R,. Besterman A; Lipska BK, Hyde TM Harrison PF, Kleinman JE, and DR Weinberger. NRG1-ErbB4-p110δ signaling in schizophrenia and evidence of p110δ inhibition as a potential therapeutic strategy. 2012 Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12165-70. PMCID: PMC3409795

Law AJ, Gothelf D, Frisch A, Chen J, Zarchi O, Michaelovsky E, Ren-Patterson R, Lipska BK, Carmel M, Kolachana B, Weizman A, Weinberger DR. Biological Effects of COMT Haplotypes and Psychosis Risk in 22q11.2 Deletion Syndrome. Biol Psychiatry.2014 Mar 1;75(5):406-13. PMCID: PMC3872263

Tost, H, Callicott, JH, Rasetti, R, Vakkalanka, R , Mattay, VS, Weinberger, DR, Law AJ* 2014. Effects of Neuregulin 3 (NRG3) genotype on human prefrontal cortex physiology. J Neurosci, 34(3):1051-1056. PMCID: PMC3891948

A Jenkins, JA. Apud, F Zhang, H Decot, DR Weinberger, AJ. Law* Common genetic Variation in NRXN1 modulates Treatment Response in Patients with Schizophrenia. Nature Neuropsychopharmacology. 2014 Aug;39(9):2170-8. PMCID: PMC4104334

Morita Y, Callicott JH, Testa LR, Mighdoll MI, Dickinson D, Chen Q, Tao R, Lipska BK, Kolachana B, Law AJ, Ye T, Straub RE, Weinberger DR, Kleinman JE, Hyde TM. J Neurosci. 2014 Apr 2;34(14):4929-40. PMID: 24695712. Characteristics of the Cation Cotransporter NKCC1 in Human Brain: Alternate Transcripts, Expression in Development, and Potential Relationships to Brain Function and Schizophrenia. PMCID: PMC3972720

C Paterson, Y Wang, JE. Kleinman and AJ Law*. Effects of Schizophrenia Risk Variation in the NRG1 Gene on NRG1-IV Splicing During Fetal and Early Postnatal Human Neocortical Development. 2014. Am J Psychiatry. 2014. Sep;171(9):979-89. PMCID: PMC4330971

AJ Law*. Genetic mouse models of neuregulin 1: gene dosage effects, isoform-specific functions, and relevance to schizophrenia. Biol Psychiatry. 2014 Jul 15;76(2):89-90.
 
C Paterson and AJ Law* Transient overexposure of Neuregulin 3 during early postnatal development impacts selective behavior. PLOS one 2014. 014 Aug 5;9(8):e104172. doi: PMCID: PMC4122441

Jenkins AK, Paterson C, Wang Y, Hyde TM, Kleinman JE, Law AJ*. Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging. Mol Psychiatry. 2016 May;21 (5):701-6. doi: 10.1038/mp.2015.107. Epub 2015 Jul 28. PMCID: PMC4731316

Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal phosphatidylcholine supplementation and offspring early childhood behavior problems: Evidence for CHRNA7 moderation. Am J Psychiatry. 2016 May 1;173(5):509-16. doi: 10.1176/appi.ajp.2015.15091188.
 
Papaleo F, Yang F, Paterson C, Palumbo S, Carr GV, Wang Y, Floyd K, Huang W, Thomas CJ, Chen J, Weinberger DR, Law AJ*. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model. J Neurosci. 2016 Apr 27;36(17):4859-75. PubMed Central PMCID: PMC4846677.

Paterson C, Wang Y, Hyde TM, Weinberger DR, Kleinman JE, Law AJ*.Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders. Am J Psychiatry. Am J Psychiatry. 2017 Mar 1;174(3):256-265

Howell KR, Floyd K, Law AJ*. PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. PLoS One. 2017 May 3;12(5):e0175993.​
​​(09/16/14-09/15/19) NIH, NIMH (Law PI). 5R01MH103716. Targets for Treating Schizophrenia: AKT in Neurodevelopment and Cognition. 

The Colorado Clinical and Translational Sciences Institute (CCTSI). (Law PI; Restrepo Co-PI) CNS-Pilot Translational Team Science Award. 2/2/17-1/31/18. Assessment of cognitive deficits and phase amplitude coupling in the hippocampus and prefrontal cortex in a Neuregulin 1 (NRG1-IVtg) genetic model of schizophrenia.
 
The Colorado Clinical and Translational Sciences Institute (CCTSI). CO-Pilot Mentored Faculty Award for Dr. Kristy Howell. 2016-2017. Gene-Environment interactions underlying neurodevelopmental disorders: Examining the impact of obstetric complications on the placenta, AKT1, brain development and function.

University of Colorado, RNA Biosciences Initiative, Transformational Research Funding. Graduate Fellowship. (Fregoso; Law Mentor). 2016-18

(2012-2015) NIH, NIMH, Conte Centre Grant. P50MH086383. (Project PI) Basic to Clinical Molecular Neurobiology of Nicotinic Receptors in Schizophrenia

(2012) Sidney R. Baer, Jr. Research Award, Brain and Behavior Research Foundation

(2006-2008) NARSAD Young Investigator Award (PI): Molecular and Functional Characterization of Type IV Neuregulin 1, a novel isoform associated with genetic risk for schizophrenia

(2005-2009) Medical Research Council, UK. Career Development Award (PI): Neuregulin-1: Dissecting the Molecular Mechanisms of Genetic Susceptibility for Schizophrenia.

(2003-2005) Wellcome Trust Project Grant (Leading Research Scientist): Investigating the Cellular and Molecular Neurobiology of a Non-Human Primate Model of Early Life Stress (University of Oxford, Prof. Paul Harrison (PI)).

(1997-2000) Medical Research Council, UK. PhD Scholarship.