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        Christian J. Hopfer, MD


Email:  Dr. Hopfer


Recent Publications


 

Christian J. Hopfer, MD

Professor


ACADEMIC APPOINTMENTS, PROFESSIONAL POSITIONS, AND HONORS

Positions and Employment:

2015 - Present  Professor of Psychiatry, University of Colorado School of Medicine

2006 -  2015  Associate Professor of Psychiatry, University of Colorado School of Medicine

1999 - 2006 Assistant Professor of Psychiatry, University of Colorado School of Medicine

1997 - 1999 Instructor of Psychiatry, University of Colorado School of Medicine

Honors:

2006 -  Present  Elected to College on Problems of Drug Dependence

2002 - 2003 President, Colorado Child and Adolescent Psychiatric Society

2012  Distinguished Fellow, American Psychiatric Association

Other Research and Professional Experience:

1998 - 2015  Director, Adult Psychiatric Services, Addiction Research and Treatment Services (ARTS)

2000 - 2003 American Academy of Child and Adolescent Psychiatry (AACAP) Substance Abuse

2006 - 2010 American Academy of Child and Adolescent Psychiatry (AACAP) Substance Abuse, Committee

2009 - 2012 AACAP Program Committee

2010 - 2013 Developmental Psychobiology Research Group Executive Director

2013 - Present  Attending Psychiatrist, Center for Dependency Addiction and Recovery (CeDAR)

Medical license - Colorado, 1993 - Present

Board Certification: American Board of Psychiatry and Neurology (Psychiatry; 2001, recertified 2011); American Board of Addiction Medicine (2016)

Memberships:

  • American Psychiatric Association, 1994 - Present
  • Colorado Psychiatric Society, 1994 - Present
  • American Academy of Child and Adolescent Psychiatry, 1995 - Present
  • Colorado Child and Adolescent Psychiatric Society, 1995 - Present
  • Developmental Psychobiology Research Group, 1997 - Present
  • Behavior Genetics Association, 1999 - Present
  • College on Problems of Drug Dependence, 2006 - Present
  • Adolescent Brain Cognitive Development (ABCD) Research Consortium, Medical Ethics & Oversight Committee, 2016 - Present
 

TEACHING ACTIVITIES 

Co-Director, “Adolescent Substance Use Disorders and Comorbidity,” subspeciality clinic and clinical course of PGYIV child psychiatry residents, University of Colorado School of Medicine, 1999 –This course trains PGY-IV child psychiatry residents in the etiology, diagnosis, and management of adolescent substance use Disorders.

Presenter, “The Big Six Substance Problems in Primary Care Medicine,” 8001 elective course for medical students, University of Colorado School of Medicine, 1999 – Present. Lecture to 1-2, 4th year medical students on “Motivational Interviewing” approximately every 4 weeks.

Presenter, “Substance Dependence for Psychiatric Residents”, PGYII course for psychiatric residents, 1999 - Present. This course trains PGYII residents in the etiology, diagnosis, and management of substance abuse disorders. Annually present one or two lectures of “Motivational Interviewing.”

Presenter:  “Psychotherapy Curriculum,” PGYIII course for psychiatry residents, 1999 - 2008. Annually present lectures on psychotherapy techniques to engage treatment-resistant clients. 

Presenter:  “Pharmacology for 4th Year Medical Students.”  Annual presentation on the pharmacology of Substance Dependence, 1999-2004.

Presenter:  NRSC 7614 - “Molecular Basis of Neuropsychiatric Disorders.” 2003-Present. Presents an overview of genetic epidemiology as it relates to conduct disorder.

Presenter/Group Leader:  Ethics in Research (PHCL 7605). 2011 – Present. Lead a group of 20-30 graduate students, post-doctoral fellows, and residents in discussions of ethical issues.

Clinical Attending 2007 - Present. Weekly supervision of PGY III integrated track child/adult resident during their rotation at the Addiction Research and Treatment Services. 

 

CLINICAL ACTIVITIES

Adult Psychiatric Director – Addiction Research and Treatment Services since 1997. Provides direct patient care to patients with comorbid drug dependence and other mental health disorders.

 

SCHOLARSHIP AND PUBLICATIONS

Current Grants and Contracts:

NIH/NIDA 1K24DA032555, Hopfer (PI), 04/01/13-03/31/18
Project Annual Direct Costs: $178,807

Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research

This award seeks support for the PI's research career and mentoring activities. Funds from the award allow the PI to expand his mentoring activities, develop additional skill sets in longitudinal data analysis and expand his program of research that involves understanding the etiology and longitudinal course of adolescent-onset substance use disorders. The PI will expand his research program by expanding his current research projects to gather more information about adolescent perceptions and patterns of marijuana use in the light of the recent “medical marijuana” explosion as well as conduct a longitudinal study that will follow a sample of both clinical and community adolescents every 6 months for 3 years to examine the development of marijuana use patterns and associated HIV-risk behaviors.


NIH/NIDA 1 R01 DA035804-01A1, Multiple PI (Hopfer, Stallings, Wall), 04/01/14-03/31/19 , Project Annual Direct Costs: $812,657

Genetics and Progression of Early-Onset Substance Dependence and HIV Risk

Dr. Hopfer is the Contact PI of this Multiple-PI project.  This proposal continues a multi-site collaboration, initiated under DA012845, to conduct a prospective study to address critical issues in the genetic epidemiology of adolescent onset antisocial drug dependence. We will complete 10-year follow-up assessments, examine drug use, HIV risk behavior, and antisocial behavior trajectories and their predictors, and we will conduct pathway-based genome wide association analyses of persistent drug dependence.


NIH/NIDA 1 R25 DA033219-01, Multiple PI (Hopfer/Sakai), 04/01/12-03/31/17, Project Annual Direct Costs: $35,475

Substance Use Disorder Research Training for Medical Students

This program recruits and trains medical students for careers as leaders in substance use research. Selected students work closely with faculty mentors who are actively engaged in substance use disorders research and participate in research training.    
Role: PI


1U01 DA041120-01, Iacono (PI), Hopfer (Co-I), 09/30/2015-05/31/2020

Adolescent Brain Cognitive Development (ABCD) - USA Consortium: Twin Research Project

This Twin Hub of the ABCD-USA Consortium, in response to RFA-DA-15-015, includes the University of Minnesota (hub leader), Virginia Commonwealth University, Washington University St. Louis, and the University of Colorado. We will prospectively determine neurodevelopmental and behavioral predictors and consequences of substance use for children and adolescents. A representative community sample of 800 twin pairs, ages 9-10 years, 200 from each of the four sites, will be tested, together with 700 singletons, contributing to the sample of 11,111 to be collected across the ABCD-USA Consortium. Dr. Hopfer is Co-I and also serves on the Medical Oversight and Bioethics Committee.


Colorado Department of Public Health and Environment, Edward Hoffenberg (PI), Hopfer (Co-I), 10/01/15- 10/01/18

The Cannabis AND Inflammatory Bowel Disease (CANDID) Study:  Do Adolescents and Young Adults with IBD Benefit from Marijuana?

The CANDID study is a longitudinal, observational study of adolescents and young adults with inflammatory bowel disease (IBD) who are followed by the IBD Center at Children's Hospital Colorado. This three-year study will enroll 200 participants ages 13-23 years who are users and non-users of cannabis to learn more about the effect of cannabis on inflammation and IBD severity. Dr. Hopfer is a Co- I on the project.


NIH/NIAAA 5T32AA007464, Hoffman (PI), 07/01/07- 06/30/18

NIAAA Institutional Postdoctoral Training Grant: Behavioral Pharmacokinetics of Drug and Alcohol Abuse

The major goal of this project is to produce well-trained independent researchers in the area of alcohol effects, alcoholism, and drug abuse. Dr. Hopfer acts a preceptor for post-doctoral trainees and program co-director.
Role: Preceptor


 Recent Peer-Reviewed Publications (* first authored by a mentee; out of +80 publications)

 *Salomonsen-Sautel S, Min SJ, Sakai JT, Thurstone C, Hopfer C. Trends in fatal motor vehicle crashes before and after marijuana commercialization in Colorado. Drug Alcohol Depend. 2014 Jul 1;140:137-44.

Melroy WE, Stephens SH, Sakai JT, Kamens HM, McQueen MB, Corley RP, Stallings MC, Hopfer CJ, Krauter KS, Brown SA, Hewitt JK, Ehringer MA. Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. Behav Genet. 2014 Jul;44(4):356-67. Epub 2014 Apr 1.

Hopfer C. Community, siblings, heritability and the risk for drug abuse. Am J Psychiatry. 2014 Feb;171(2):140-1.

Hopfer C. Implications of marijuana legalization for adolescent substance use. Subst Abus. 2014;35(4):331-5.

Derringer J, Corley RP, Haberstick BC, Young SE, Demmitt BA, Howrigan DP, Kirkpatrick RM, Iacono WG, McGue M, Keller MC, Brown S, Tapert S, Hopfer CJ, Stallings MC, Crowley TJ, Rhee SH, Krauter K, Hewitt JK, McQueen MB. Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample.Behav Genet. 2015 Jan 31.

Coors ME, Raymond KM, McWilliams SK, Hopfer CJ, Mikulich-Gilbertson SK. What adolescents enrolled in genomic addiction research want to know about conflicts of interest. Drug Alcohol Depend. 2015 Feb 1;147:272-5. Epub 2014 Dec 15.

Coors ME, Raymond KM, McWilliams SK, Hopfer CJ, Mikulich-Gilbertson SK. Adolescent perspectives on the return of individual results in genomic addiction research. Psychiatr Genet. 2015 Mar 5. [Epub ahead of print] PMID: 25748091.

Melroy-Greif WE, Vadasz C, Kamens HM, McQueen MB, Corley RP, Stallings MC, Hopfer CJ, Krauter KS, Brown SA, Hewitt JK, Ehringer MA. Test for association of common variants in GRM7 with alcohol consumption. Alcohol. 2016 Sep;55:43-50. doi: 10.1016/j.alcohol.2015.10.005. PMID: 27788777.

Luk JW, Worley MJ, Winiger E, Trim RS, Hopfer CJ, Hewitt JK, Brown SA, Wall TL. Risky driving and sexual behaviors as developmental outcomes of co-occurring substance use and antisocial behavior. Drug Alcohol Depend. 2016 Dec 1;169:19-25. doi: 10.1016/j.drugalcdep.2016.10.006. PMID: 27750183.

Hopfer C. Declining Rates of Adolescent Marijuana Use Disorders During the Past Decade May Be Due to Declining Conduct Problems. J Am Acad Child Adolesc Psychiatry. 2016 Jun;55(6):439-40. doi: 10.1016/j.jaac.2016.03.013. PMID: 27238061.

Choi TK, Worley MJ, Trim RS, Howard D, Brown SA, Hopfer CJ, Hewitt JK, Wall TL. Effect of adolescent substance use and antisocial behavior on the development of early adulthood depression. Psychiatry Res. 2016 Apr 30;238:143-9. doi: 10.1016/j.psychres.2016.02.036. PMID: 27086224.

Kamens HM, Corley RP, Richmond PA, Darlington TM, Dowell R, Hopfer CJ, Stallings MC, Hewitt JK, Brown SA, Ehringer MA. Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence. Behav Genet. 2016 Sep;46(5):693-704. doi: 10.1007/s10519-016-9792-4. PMID: 27085880.

Stringer S, Minică CC, Verweij KJ, Mbarek H, Bernard M, Derringer J, van Eijk KR, Isen JD, Loukola A, Maciejewski DF, Mihailov E, van der Most PJ, Sánchez-Mora C, Roos L, Sherva R, Walters R, Ware JJ, Abdellaoui A, Bigdeli TB, Branje SJ, Brown SA, Bruinenberg M, Casas M, Esko T, Garcia-Martinez I, Gordon SD, Harris JM, Hartman CA, Henders AK, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Huizink AC, Irons DE, Kahn RS, Korhonen T, Kranzler HR, Krauter K, van Lier PA, Lubke GH, Madden PA, Mägi R, McGue MK, Medland SE, Meeus WH, Miller MB, Montgomery GW, Nivard MG, Nolte IM, Oldehinkel AJ, Pausova Z, Qaiser B, Quaye L, Ramos-Quiroga JA, Richarte V, Rose RJ, Shin J, Stallings MC, Stiby AI, Wall TL, Wright MJ, Koot HM, Paus T, Hewitt JK, Ribasés M, Kaprio J, Boks MP, Snieder H, Spector T, Munafò MR, Metspalu A, Gelernter J, Boomsma DI, Iacono WG, Martin NG, Gillespie NA, Derks EM, Vink JM. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Transl Psychiatry. 2016 Mar 29;6:e769. doi: 10.1038/tp.2016.36. PMID: 27023175

Bartels K, Binswanger IA, Hopfer CJ. Sources of Prescription Opioids for Nonmedical Use. J Addict Med. 2016 Mar-Apr;10(2):134. doi: 10.1097/ADM.0000000000000192. PMID: 26985647.

Haberstick BC, Boardman JD, Wagner B, Smolen A, Hewitt JK, Killeya-Jones LA, Tabor J, Halpern CT, Brummett BH, Williams RB, Siegler IC, Hopfer CJ, Mullan Harris K. Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). PLoS One. 2016 Mar 3;11(3):e0148373. doi10.1371/journal.pone.0148373. PMID: 26938215.

Trim RS, Worley MJ, Wall TL, Hopfer CJ, Crowley TJ, Hewitt JK, Brown SA. Bivariate Trajectories of Substance Use and Antisocial Behavior: Associations with Emerging Adult Outcomes in a High-Risk Sample. Emerg Adulthood. 2015 Aug 1;3(4):265-276. PMID: 26889401.

Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid Use and Storage Patterns by Patients after Hospital Discharge following Surgery. PLoS One. 2016 Jan 29;11(1):e0147972. doi: 10.1371/journal.pone.0147972. PMID: 26824844.

Coors ME, Raymond KM, Hopfer CJ, Sakai J, McWilliams SK, Young S, Mikulich-Gilbertson SK. Adolescents with substance use disorder and assent/consent: Empirical data on understanding biobank risks in genomic research.Drug Alcohol Depend. 2016 Feb 1;159:267-71. doi: 10.1016/j.drugalcdep.2015.12.006. PMID: 26774949.

El Omari F, Salomonsen-Sautel S, Hoffenberg A, Anderson T, Hopfer C, Toufiq J. Prevalence of substance use among moroccan adolescents and association with academic achievement. World J Psychiatry. 2015 Dec 22;5(4):425-31. doi: 10.5498/wjp.v5.i4.425. PMID: 26740934.

Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL. Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet. 2016 Mar;46(2):151-69. doi: 10.1007/s10519-015-9737-3. PMID: 26392368.

Coors ME, Raymond KM, McWilliams SK, Hopfer CJ, Mikulich-Gilbertson SK. Adolescent perspectives on the return of individual results in genomic addiction research. Psychiatr Genet. 2015 Jun;25(3):127-30. doi: 10.1097/YPG.0000000000000083. PMID: 25748091

Derringer J, Corley RP, Haberstick BC, Young SE, Demmitt BA, Howrigan DP, Kirkpatrick RM, Iacono WG, McGue M, Keller MC, Brown S, Tapert S, Hopfer CJ, Stallings MC, Crowley TJ, Rhee SH, Krauter K, Hewitt JK, McQueen MB. Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. Behav Genet. 2015 Jul;45(4):375-81. doi: 10.1007/s10519-015-9705-y. PMID: 25637581.

Coors ME, Raymond KM, McWilliams SK, Hopfer CJ, Mikulich-Gilbertson SK. What adolescents enrolled in genomic addiction research want to know about conflicts of interest. Drug Alcohol Depend. 2015 Feb 1;147:272-5. doi:10.1016/j.drugalcdep.2014.12.004. PMID:  25577477.

Hopfer C. Implications of Marijuana Legalization for Adolescent Substance Use. Subst Abus. 2014;35(4):331-5. doi: 10.1080/08897077.2014.943386. PMID: 25127003.

*Wills AG, Evans LM, Hopfer C. Phenotypic and Genetic Relationship Between BMI and Drinking in a Sample of UK Adults. Behav Genet. 2017 Feb 25. doi: 10.1007/s10519-017-9838-2. [Epub ahead of print] PMID: 28238197.

 
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