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Thomas J. Crowley, MD

Professor Emeritus


Contact Info:
Recent Publications
 
Clinical/Research Interests:

Dr. Crowley’s group has established a program, unique in the nation, to simultaneously treat and study adolescents with substance dependence (SD) and conduct disorder (CD).​

Education:

University of Minnesota, BA 1960
University of Minnesota Medical School, MD 1962

Selected from more than 150 peer-reviewed publications

Dalwani, M., Sakai, J. T., Mikulich-Gilbertson, S. K., Tanabe, J., Raymond, K., McWilliams, S. K., Thompson, L., Banich, M. T., Crowley, T. J. (2011, in press). Reduced cortical gray matter volume in male adolescents with substance and conduct problems. Drug and Alcohol Dependence.

Sakai, J. T., Crowley, T. J., Stallings, M. C., McQueen, M., Hewitt, J. K., Hopfer, C., Hoft, N. R., Ehringer, M. A. (2010, submitted). Test of association between 10 SNPs in the oxytocin receptor gene and conduct disorder. Psychiatric Genetics.

Sakai, J. T., Dalwani, M., Gelhorn, H. L., Mikulich-Gilbertson, S. K., Crowley, T. J. (2010, submitted). Assessing self-oriented vs. other-oriented behavior among adolescents with conduct and substance problems. Journal of Clinical Child and Adolescent Psychology.

Boardman, J. D., Blalock, C. L., Corley, R. P., Stallings, M. C., Domingue, B. W., McQueen, M. B., Crowley, T. J., Hewitt, J. K., Lu, Y., Field, S. H. (2010). Ethnicity, Body Mass, and Genome-Wide Data. Biodemography and Social Biology56, 123-136.

Crowley, T. J., Dalwani, M. S., Mikulich-Gilbertson, S. K., Du, Y. P., Lejuez, C. W., Raymond, K. M., Banich, M. T. (2010). Risky Decisions and Their Consequences: Neural Processing by Boys with Antisocial Substance Disorder. PLoS ONE5(9), e12835

Crowley, T. J., Gelhorn, H. (2010). Antisocial Substance Dependence. In G. Koob, R. F. Thompson and M. Le Moal (Eds.), Encyclopedia of Behavioral Neuroscience. (pp. 101-108). Oxford: Elsevier Science.

Sakai, J. T., Stallings, M. C., Crowley, T.J., Gelhorn, J. L., McQueen, M. B., Ehringer, M. A. (2010). Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. Drug and Alcohol Dependence106, 199-203.

Gelhorn, H., Hartman, C., Sakai, J., Mikulich-Gilbertson, S., Stallings, M., Young, S., Rhee, S. H., Corley, R., Hewitt, J., Hopfer, C., Crowley, T. (2009). An Item Response Theory analysis of DSM-IV Conduct Disorder. Journal of the American Academy of Child and Adolescent Psychiatry48, 42-50.

Hartman, C. A., Hopfer, C. J., Haberstick, B., Rhee, S. H., Crowley, T. J., Corley, R. P., Hewitt, J. K., Ehringer, M. A. (2009). The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. Drug and Alcohol Dependence104, 11-16.

Palmer, R. H., Young, S. E., Hopfer, C. J., Corley, R. P., Stallings, M. C., Crowley, T. J., Hewitt, J. K. (2009). Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk. Drug and Alcohol Dependence102, 78-87.

Sakai, J. T., Crowley, T. J. (2009). Inhalant Related Disorders. In B. J. Sadock, V. A. Sadock, & P. Ruiz (Eds.), The Comprehensive Textbook of Psychiatry, 9th ed. (pp. 1341-1352). Baltimore, MD: Williams & Wilkins.

Tanabe, J., Tregellas, J., Dalwani, M., Thompson, L., Owens, E., Crowley, T., Banich, M. (2009). Medial orbitofrontal cortex gray matter is reduced in abstinent substance dependent individuals. Biological Psychiatry65, 160-164.

Coors, M. E., Mikulich-Gilbertson, S. K., Raymond, K. M., Stover, S. K., Tapert, S. F., Brown, S. A., Crowley, T.J. (2008). Directives for retained DNA: preferences of adolescent patients with substance and conduct problems and their siblings. American Journal of Bioethics8, 77-79.

Corley, R. P., Zeiger, J. S., Crowley, T.J., Ehringer, M.A., Hewitt, J.K., Hopfer, C.J., Lessem, J., McQueen, M. B., Rhee, S. H., Smolen, A., Stallings, M. C., Young, S. E., Krauter, K. (2008). Association of candidate genes with antisocial drug dependence in adolescents. Drug and Alcohol Dependence96, 90-98.

Gelhorn, H., Hartman, C., Sakai, J., Stallings, M., Young, S., Rhee, S., Corley, R., Hewitt, J., Hopfer, C., Crowley, T. (2008). Toward DSM-V: An Item Response Theory analysis of DSM-IV alcohol abuse and dependence criteria in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry47, 1329-1339.

Hartman, C. A., Gelhorn, H., Crowley, T. J., Sakai, J., Stallings, M. C., Young, S. E., Corley, R., Hewitt, J. K., Hopfer, C.J. (2008). An Item Response Theory analysis of DSM-IV marijuana abuse and dependence criteria in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry47, 165-173.

Schulz-Heik, R. J., Maentz, S. K., Rhee, S. H., Gelhorn, H. L., Young, S. E., Stallings, M. C., Timberlake, D., Smolen, A., Stetler, G. L., Sakai, J. T., Crowley, T. J. (2008). Case-control and within-family tests for an association between conduct disorder and DAT1. Psychiatric Genetics18, 17-24.

Tanabe, J., Crowley, T., Hutchison, K., Miller, D., Johnson, G., Du, Y. P., Zerbe, G., Freedman, R. (2008). Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotine. Neuropsychopharmacology33, 627-633.

Zeiger, J. S., Haberstick, B. C., Schlaepfer, I., Collins, A. C., Corley, R. P., Crowley, T. J., Hewitt, J. K., Hopfer, C. J., Lessem, J., McQueen, M. B., Rhee, S. H., Ehringer, M. A. (2008). The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco. Human Molecular Genetics17, 724-734.

Anderson, K. G., Tapert, S. F., Moadab, I., Crowley, T. J., Brown, S. A. (2007). Personality risk profile for conduct disorder and substance use disorders in youth. Addictive Behaviors32, 2377-2382.

Banich, M. T., Crowley, T. J., Thompson, L. L., Jacobson, B. J., Liu, X., Raymond, K. M., Claus, E. D. (2007). Brain activation during the Stroop task in adolescents with severe substance and conduct problems: A pilot study. Drug and Alcohol Dependence90, 175-182.

Crowley, T. J. (2007). Adolescents and substance related disorders: Research agenda to guide decisions in DSM-V. In J. B. Saunders, M. A. Schuckit, P. J. Sirovatka, & D. A. Regier (Eds.), Diagnostic Issues in Substance Use Disorders: Refining the Research Agenda for DSM-V(pp 203-220). Arlington, VA: American Psychiatric Association.

Ehringer, M., Clegg, H., Collins, A., Corley, R., Crowley, T., Hewitt, J., Hopfer, C., Krauter, K., Lessem, J., Rhee, S., Schlaepfer, I., Smolen, A., Stallings, M. C., Young, S. E., Zeiger, J. S. (2007). Association of the neuronal nicotinic receptor b2 subunit gene (CHRNB2) w/subjective responses to alcohol & nicotine. Neuropsychiatric Genetics144B, 596-604.

Gelhorn, H. L., Sakai, J. T., Price, R. K., Crowley, T. J. (2007). DSM-IV Conduct disorder criteria as predictors of antisocial personality disorder. Comprehensive Psychiatry48, 529-538.

Hopfer, C. J., Lessem, J. M., Hartman, C. A., Stallings, M. C., Cherny, S. S., Corley, R. P., Hewitt, J. K., Krauter, K. S., Mikulich-Gilbertson, S. K., Rhee, S. H., Smolen, A., Young, S. E., Crowley, T. J. (2007). A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9. Drug and Alcohol Dependence89, 34-41.

Sakai, J., Hopfer, C., Hartman, C., Haberstick, B., Smolen, A., Corley, R., Stallings, M., Young, S., Timberlake, D., Hewitt, J., Crowley, T. (2007). Test of association between TaqIA A1 allele & alcohol use disorder phenotypes in a sample of adolescent patients with serious substance & behavioral problems. Drug and Alcohol Dependence88, 130-137.

Schlaepfer, I., Clegg, H. V., Corley, R. P., Crowley, T., Hewitt, J. K., Hopfer, C. J., Krauter, K., Lessem, J., Rhee, S. H., Stallings, M. C., Wehner, J. M., Young, S. E., Ehringer, M. A. (2007). The human protein kinase C-gamma gene (PRKCG) as a susceptibility locus for hyperactive/impulsive behaviors. Addiction Biology12, 200-209.

Crowley, T. J. (2006). Adolescents and substance related disorders: Research agenda to guide decisions in DSM-V. Addictions101(S1), 115-124.​

GRANTS AND CONTRACTS 

2P60 DA 011015-12 (Hewitt)         08/01/1997-02/28/2014

NIH/NIDA

Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors- Crowley, Co-Director

      Core A: Administrative, Educational, and Ethics Core- Crowley, Co-PI,

      Comp. 3: A Neurogenetic Basis for Risky Hiv-Related Decisions- Crowley, PI,

Center representing the University of Colorado’s Institute for Behavioral Genetics, Division of Substance Dependence and Molecular, Cellular, and Developmental Biology.  This center conducts research in antisocial drug dependence, human behavioral genetics and HIV Risk Behaviors.

 

5R01 DA009842-15 (Crowley)           09/05/2006-04/30/2011                       (MERIT Award in yrs 6-10)   

NIH/NIDA                                           

Substance Dependent Adolescents: Imaging Risk-Taking

The objective of this research is to better understand whether substances diminish the capacity to inhibit behavior by altering brain processing of risky decisions, or do pre-existing, anatomically-based variations of brain processing produce risk-taking propensities, or both.

 

1R01 DA027748-01 (Tanabe)                09/01/2009-08/31/2014          

NIH/NIDA                                            

Neural Correlates of Avoidance Learning in Substance Abuse

This project, which is based on a negative reinforcement model of drug addiction, will investigate neural correlates of negative reinforcement learning and its relationship to negative affective states in substance dependence.

 

5 T32 AA 007464-33 (Hoffman)         07/1/2007-06/30/2012 Preceptor

NIH/NIAAA

NIAAA Institutional Postdoctoral Training Grant: Behavioral Pharmacogenetics of Drug and Alcohol Abuse

The major goal of this project is to produce well-trained independent researchers in the area of alcohol effects, alcoholism, and drug abuse.