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Department of Physiology and Biophysics

University of Colorado Department of Physiology and Biophysics
 

Abigail Person, PhD

Assistant Professor









Department of Physiology and Biophysics
University of Colorado School of Medicine

RC1 North Tower, P18-7119​
Mail Stop 8307
Aurora, CO 80045​
Tel: (303) 724-4514
Fax: (303) 724-4501​

E-mail: Abigail.Person@ucdenver.edu

  • Neuroscience Graduate Program
  • Bioengineering
  • MSTP
  • BSP
​​


Abigail Person's laboratory studies the contribution of the cerebellum to motor control, focusing on circuit mechanisms that support smooth, precise movement. A central idea in cerebellar physiology is that the position of the body is monitored via copies of motor commands conveyed by "corollary discharge pathways". By combining physiology, optogenetics, anatomical methods, and behavior we address how cerebellar circuitry makes movements precise. These topics are at the heart of the role of the cerebellum as a sensorimotor integrator. Disorders of this circuitry are hypothesized to contribute to some aspects of disorders such as autism and schizophrenia as well as broad motor disturbances seen in cerebellar ataxias.

 

Sawako Fukushima, PhD

Postdoctoral Fellow

Sawako.Fukushima@ucdenver.edu

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Christy Beitzel

Graduate Student

Christy.Beitzel@ucdenver.edu



​Ted Doykos

Graduate Student

Theodore.Doykos@ucdenver.edu

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Coming Soon

Matt Becker

MSTP Student

 

 

 

Person AL, Khodakhah K (2016) Recurrent Feedback Loops in Associative Learning. Neuron. Feb 3;89(3):427-30

Houck BD, Person AL (2015) Cerebellar Premotor Output Neurons Collateralize to Innervate the Cerebellar Cortex. J Comp Neurol. Oct 15;523(15):2254-71

Houck BD, Person AL (2014) Cerebellar loops: a review of the nucleocortical pathway. Cerebelum. 13:378-85

Heck DH, De Zeeuw CI, Jaeger D, Khodakhah K, Person AL (2013) The neuronal code(s) of the cerebellum. J Neurosci. 2013 33:17603-9

Person AL, Raman IM. (2012) Synchrony and neural coding in cerebellar circuits. Front Neural Circuits. 6:97

Person AL, Raman IM (2011) Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature 481: 502-5

Person AL, Raman IM (2010) Deactivation of L-type calcium current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei. Neuron 66: 550-559

Person AL*, Gale SD*, Farries MA, Perkel DJ. (2008) Organization of songbird basal ganglia, including area X. J Comp Neurol 508: 840:66
*equal contribution

Gale SD*, Person AL*, Perkel DJ. (2008) A novel basal ganglia pathway forms a loop linking a vocal learning circuit with its dopaminergic input. J Comp Neurol 508: 824-39
*equal contribution

Person AL, Perkel DJ (2007) Pallidal neuron activity increases during sensory relay through thalamus in a songbird circuit essential for learning. J Neurosci 27: 8687-98.

Person AL, Perkel DJ (2005) Unitary IPSPs drive precise thalamic spiking in a circuit required for learning. Neuron 46: 129-40.

Honors and Awards:

  • Alfred P. Sloan Research Fellow
  • Esther A and Joseph Klingenstein Fund Award in the Neurosciences
  • Boettcher Investigator: Webb-Waring Biomedical Research Award