overarching goal of the Verneris laboratory is to create new targeted immune
therapies to treat cancer in children and adults.
Our laboratory is focused on using stem cells
to create "off the shelf" living drugs to treat cancer and other diseases. To do
this we use hematopoietic stem cells and induced pluripotent stem cells to
understand how these cells give rise to natural killer (NK) cells and T
cells. Thus, our research is in two
1. Stem Cell
seek to understand how stem cells can be expanded and manipulated to
differentiate into lymphocytes. We work
with established embryonic and induced pluripotent stem cells, as well as
hematopoietic stem cells derived from cord blood and bone marrow. Our studies are focused on stem cell biology
and differentiation into the lymphocyte lineage (including NK cells, T cells,
and innate lymphoid cells).
2. Lymphocyte Biology
We have focused on redirecting the immune
system to cancer. Studies include the
use and development of bi- and trispecific immune killer engagers (BiKes and
TriKes) and chimeric antigen receptors (CARs). We have also discovered a how to differentiate stem cells to innate
lymphoid cells and natural killer cells. We are using drugs and genetic screens to enhance this process and
genetic manipulation to increase their activity and homing into solid tumors
(sarcoma and brain tumors). The long
term goal is to have an "off the shelf" living drug that can be used to
mitigate graft vs. host disease, inflammatory bowel disease and cancer.
View our videos on:
or Fellow Positions
The lab is
currently accepting applications for post-doctoral fellows. A PhD, MD, or equivalent is required. The successful applicant will also have a
strong record of productivity in fields such as the study of gene expression in
various systems, immunology, hematology/oncology or related topics. Interested applicants should send a CV, cover
letter expressing interests and long-term career goals, and contact information
for three references.
seeks highly motivated students for rotations and ultimately for graduate
training from the umbrella BSP, Pharmacology, Cancer Biology, Molecular
Biology, Cell and Developmental Biology and MSTP programs.
Phone: (720) 777-5168
of Colorado/Anschutz Medical Campus
of Pediatrics, Hematology/Oncology/BMT
19th Ave. Mail Stop #8302
(UPS, Fedex Ground)
of Colorado, Anschutz Medical Campus