Skip to main content
Sign In
 

Dr. Michael Verneris Lab


Our Goal

The overarching goal of the Verneris laboratory is to create new targeted immune therapies to treat cancer in children and adults. 
 

Our Focus

Our laboratory is focused on using stem cells to create "off the shelf" living drugs to treat cancer and other diseases. To do this we use hematopoietic stem cells and induced pluripotent stem cells to understand how these cells give rise to natural killer (NK) cells and T cells. Thus, our research is in two broad areas: 
 
1. Stem Cell Biology
We seek to understand how stem cells can be expanded and manipulated to differentiate into lymphocytes.  We work with established embryonic and induced pluripotent stem cells, as well as hematopoietic stem cells derived from cord blood and bone marrow. Our studies are focused on stem cell biology and differentiation into the lymphocyte lineage (including NK cells, T cells, and innate lymphoid cells).
 
2. Lymphocyte Biology
We have focused on redirecting the immune system to cancer. Studies include the use and development of bi- and trispecific immune killer engagers (BiKes and TriKes) and chimeric antigen receptors (CARs). We have also discovered a how to differentiate stem cells to innate lymphoid cells and natural killer cells. We are using drugs and genetic screens to enhance this process and genetic manipulation to increase their activity and homing into solid tumors (sarcoma and brain tumors). The long term goal is to have an "off the shelf" living drug that can be used to mitigate graft vs. host disease, inflammatory bowel disease and cancer.

View our videos on:


Publications


Joining the Lab

Post-Doctoral or Fellow Positions

The lab is currently accepting applications for post-doctoral fellows. A PhD, MD, or equivalent is required.  The successful applicant will also have a strong record of productivity in fields such as the study of gene expression in various systems, immunology, hematology/oncology or related topics. Interested applicants should send a CV, cover letter expressing interests and long-term career goals, and contact information for three references.

Graduate Student Positions

Our lab seeks highly motivated students for rotations and ultimately for graduate training from the umbrella BSP, Pharmacology, Cancer Biology, Molecular Biology, Cell and Developmental Biology and MSTP programs.  


Contact Us

Email: Michael.verneris@ucdenver.edu
Office Phone: (720) 777-5168
Lab Phone: (303) 724-4006
Fax: (303) 724-4015

US Mail
University of Colorado/Anschutz Medical Campus
Department of Pediatrics, Hematology/Oncology/BMT
12800 E. 19th Ave. Mail Stop #8302
Room P18-4108
Aurora, CO 80045

Shipping (UPS, Fedex Ground)
Verneris Lab
University of Colorado, Anschutz Medical Campus
12800 E. 19th Avenue
Aurora, CO 80045