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The Keating Lab

Abnormal signaling through receptor tyrosine kinases (RTKs) is a well described mechanism of malignancy.  Our laboratory studies the TAM family of RTKs and their role in malignant astrocytoma and glioblastoma multiforme.  We have demonstrated that inhibition of TAM RTK activation leads to significantly decreased cell growth and migration and increased chemosensitivity, through both increased apoptosis and autophagy.  Our goal is to further understand the pathways and mechanisms altered by the inhibition of TAM RTKs and eventually translate these findings to a novel therapeutic approach for these difficult to treat tumors.