Developmental Lung Biology Laboratory
Director: Kurt R. Stenmark, MD
The Developmental Lung Biology Laboratory is located in Research 2 on the new UCSOM Anschutz Medical Campus. There is approximately 7,000 sq. ft. of research space, including core cell culture and imaging labs. Presently, the group consists of three physicians and three full-time PhD researchers, as well as doctoral and postdoctoral research fellows, including pediatric critical care fellows. Current areas of investigation include both normal and pathologic mechanisms involved in lung cell growth and development, factors controlling vascular tone and structure in the pulmonary circulation, and responses of the vasculature to injury. A current emphasis is on the role of inflammation and progenitor cells in pulmonary vascular remodeling.
Pediatric Critical Care Clinical Research Program
Director: Peter Mourani, MD
The Pediatric Critical Care Clinical Research Program supports clinical and translational research projects within the Children’s Hospital Colorado Pediatric Intensive Care Unit. With the contribution of many of the Critical Care faculty as well as investigators from outside the Section, the program provides the infrastructure to execute investigator initiated and multi-center studies, including feasibility analysis, research management, and mentorship and research training. The program participates in the Virtual PICU System (VPS), a clinical database dedicated to standardized data sharing and benchmarking among pediatric ICUs. Present local studies include: the role of the airway microbiome in ventilator-associated pneumonia, the impact of Vitamin D in respiratory disease among preterm infants, hyponatremia in critical illness, acute lung injury, immune tolerance in sepsis, and Provider - Family Communication During Family Meetings . The program also participates in several multicenter studies including the Genetic Epidemiology of Influenza in Children, Heart and Lung Injury – Pediatric Insulin Titration Trial, Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT), Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care, and Age of Blood in Children in Pediatric Intensive Care Units.
Children’s Clinical Research Organization:
Director: Lalit Bajaj, MD; Associate Directors: Peter Mourani, MD and Tim Bernard, MD
The Children’s Clinical Research Organization (CCRO) at the Children's Hospital Colorado (CHCO) provides comprehensive research services, facilities and personnel to support the facilitation and conduct of research, including research start-up, execution and close-out. The CCRO sits within the CHCO Research Institute and is the primary centralized implementation and coordination organization for execution of clinical research at CHCO. https://research.childrenscolorado.org/content/childrens-clinical-research-organization-ccro-overview
Cardiovascular Pulmonary Laboratory (CVP)
Director: Kurt R. Stenmark, MD
Also located in Research 2 at the UCSOM Anschutz Medical Campus, the Cardiovascular Pulmonary Research (CVP) Laboratory comprises over 10,000 sq. ft. of laboratory space. It offers research opportunities in cardiovascular-pulmonary physiology and cell biology. Topics of research include the pulmonary circulation, acute lung injury, endothelial cell damage, as well as high altitude physiology. Drs. Dwight Klemm, Sonia Flores, Jack Dempsey, Dave Irwin, and Raphael Nemenoff offer an outstanding research experience for fellows in a collaborative relationship with the UCSOM Department of Medicine.
The Department of Bioengineering’s mission is to improve human health through the application of engineering principles, ideas, methods, and inventions in order to solve important clinical problems. Staffed with 8 core PhD’s, over 35 affiliated MD and PhD faculty, and more than two dozen graduate students, this department has active projects in cardiovascular biomechanics and hemodynamics, diabetes, imaging and biophotonics, neuroscience engineering, ophthalmology, orthopedic biomechanics, and surgery and urological sciences.
Pediatric Heart Lung Center
Director: Steve Abman, MD
Research in the Pediatric Heart Lung Center includes both clinical and laboratory based studies that employ diverse approaches to heart and lung problems. General topics include studies on acute lung injury, neonatal pulmonary hypertension, respiratory distress syndrome in premature newborns, chronic lung disease after premature birth (bronchopulmonary dysplasia; BPD); postoperative cardiac care, long-term management of pulmonary hypertension, and others. Current studies include: basic science laboratory investigations, single-center physiologic and outcome studies, and multicenter randomized clinical trials.
National Jewish Health (NJH)
On a separate campus near Children's Colorado and UCSOM, NJH has major investigative programs in basic immunology as well as physiological disturbances in pulmonary disease, with emphasis on airway smooth muscle function, exercise-induced bronchospasm, respiratory muscle strength and lung mechanics.