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Gastrointestinal Eosinophilic Diseases Program - Research


 

The Gastrointestinal Eosinophil Research Program (GERP) performs novel research focusing on eosinophils’ impact on the gastrointestinal tract. Studies center on the mechanisms that eosinophils relate to resident cells of the intestinal tract and how these relationships contribute to host health and disease.

The GERP is a part of the Mucosal Inflammation Program (MIP) in the Gastroenterology Division at the University of Colorado School of Medicine (CU SOM) that is directed by Dr. Sean Colgan. The MIP carries an overall theme of determining mechanisms of inflammation at a variety of mucosal surfaces including the GI tract and the lung.  Taken together, the Gastrointestinal Eosinophilic Diseases Program and Mucosal Inflammation Program unite a unique blend of basic and clinical investigators. This integration of basic and clinical sciences and multidisciplinary approach fosters collaboration between key personnel from different divisions of CU SOM to provide outstanding patient care and novel research outcomes.

 

Related Web sites and Additional Information


Visit the NASPGHAN First International Gastrointestinal Eosinophil Research Symposium Web site, which includes links to many online presentations, including Dr. Furuta's narrated slideshow.

The GERP consists of two investigators and two postdoctoral fellows. Dr. Glenn Furuta, is a physician-scientist whose work examines the role of eosinophil's GI function. Dr. Sophie Fillon is an Instructor of Pediatrics with an expertise in microbiology, host pathogen interaction, and innate defense mechanisms. Dr. Fillon’s research goal is identify the role of bacteria in the pathogenesis of eosinophilic gastrointestinal diseases. Dr. Joanne Masterson is an Instructor of Pediatrics with a research focus on eosinophils and intestinal remodeling. The goal of her studies is to identify novel therapeutic targets and strategies to prevent, treat, and cure intestinal diseases. Dr. Kelly Capocelli is an Assistant Professor of Pathology whose research interests include the pathophysiology of eosinophilic gastrointestinal diseases, transplant pathology, and hemovigilance in transfusion medicine. Lindsay Hosford, BS, is a professional research assistant. Wendy Moore, MPH, is the translational research coordinator who manages the clinical research protocols and handles recruitment of study subjects. She acts as liaison with the Colorado Multiple Institutional Review Board to ensure all research meets the highest scientific and ethical standards. The laboratory is currently located in the Research Complex II at the Anschutz Medical Campus in Aurora, Colorado.