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TCH Clinical & Translational Research Center - Research


 

The TCH Clinical & Translational Research Center supports between 125-150 active protocols at any one time. Currently, there are 49 investigators with active protocols.

Frank J. Accurso, MD

  • A Double-Blind, Multicenter, Multinational, Randomized, Placebo-Controlled Trial Evaluating Aztreonam Lysine for Inhalation in Patients with Cystic Fibrosis, Mild Lung Disease, and Pseudomonas aeruginos
  • A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Crossover Study to Evaluate the Effectiveness and Safety of PANCRECARB MS-16 (Pancrelipase) in Reducing Steatorrhea in Children and Adults with Cystic Fibrosis
  • A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Study Evaluating the Efficacy and Safety of ALTU-135 Treatment in Patients with Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency
  • A Phase I/II Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Dose Escalation Study of KB001 in Cystic Fibrosis Patients Infected with Pseudomonas aeruginos

Susan Apkon, MD

  • Estimation of the Energy Savings Attributed to Control of Spasticity in Children with Cerebral Palsy Using an Intrathecal Baclofen Pump

Jennifer M. Barker, MD

  • Oral Insulin for the Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus

Frederick C. Battaglia, MD

  • Transplacental Gradients,Transport, and Production of Polyols and Manose in Normal and IUGR Pregnancies

Melissa A. Cadnapaphornchai, MD

  • Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus

James Carollo, PhD, PE

  • Rhythmic Auditory Stimulation as a Gait Intervention for Children with Cerebral Palsy

Emily L. Dobyns, MD

  • Evaluation of Adrenal Reserve and Response to Low-Dose ACTH (Corticotrophin) Stimulation in Critically Ill Children

Rosanna V. Fiallo-Scharer, MD

  • The Effect of Using Terbutaline or a Reduction in Basal Insulin Infusion as a Therapeutic Agent to Prevent Delayed Nocturnal Hypoglycemia in Children and Adolescents with Type 1 Diabetes
  • Reversal of Hypoglycemia Unawareness Using Continuous Glucose Monitoring

Robert Friesen, MD

  • Depth of Anesthesia and the Incidence of Emergence Agitation and Post-Operative Behavioral Changes in a Population of Pediatric Dental Patients

Robin L. Gabriels, PsyD

  • Evaluating the Effects of a Visual Pedagogy and Structure on the Successful Completion of the Medical Office Visit and Physical Examination with Pre-Pubescent Children with Autism

Peter A. Gottlieb, MD

  • Effects of CTLA4-log (Abatacept) on the Progression of Type 1 Diabetes in New Onset Subjects

D. Dunbar Ivy, MD, and David Badesch, MD

  • Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy

John P. Kinsella, MD

  • Pilot Trial of rhSOD in Term Newborns with PPHN

Ulrich Klein, DDS

  • Immunological Marker Assays in Children Receiving Dental Rehabilitation Under General Anesthesia Before and After Extraction: A Pilot Study

Nancy F. Krebs, MD

  • Meeting Zinc (Zn) and Iron (Fe) Requirements for Older Breastfed Infants: Comparison of Complementary Feeding Strategies

Myron J. Levin, MD

  • IMPAACT P1065: Phase I/II Study of Safety and Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine in HIV-Infected Youth

David M. Maahs, MD

  • Trial of Zocor and Vytorin in Adolescents with Type 1 Diabetes

Elizabeth McFarland, MD

  • Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women (SMARTT Study)
  • IMPAACT P1066: Phase I/II Multicenter, Open-Label, Noncomparative Study of the International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Group to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiretroviral Activity of Raltegravir (MK-0518) in HIV-1 Infected Children and Adolescents

James McManaman, MD

  • March of Dimes UCD Preterm Birth Biomarker Study

Lisa Miller, MD

  • National CADDRE Study: Child Development and Autism

Elaine H. Morrato, DrPH

  • Periodontal Health Status of Adolescents with Type 1 Diabetes

Michael R. Narkewicz, MD

  • Fecal Behenic Acid: A New Marker for Fat Malabsorption

Rachelle Nuss, MD

  • Effectiveness of Hydroxyurea and Magnesium Pidolate Alone and in Combination in Hemoglobin SC Disease A Phase II Trial

David Partrick, MD, and Robert McIntyre, MD

  • The Effect of Blunt Trauma and Burn Injury on the Inflammatory Response in Pediatric Patients

David Polaner, MD

  • Does Total Intravenous Anesthesia with Propofol for Greater than 4 Hours Produce Occult Biochemical Evidence of the Propofol Infusion Syndrome?

Melanie S. Reece, PhD, and Linda A. Barbour, MD, MSPH

  • Regulation of Maternal Fuel Supply and Neonatal Adiposity

Tonia M. Sabo-Graham, MD

  • Pilot Study to Define Nutritional Interrelationships of CoQ10, Riboflavin, and Magnesium in the Evaluation and Treatment of Childhood Migraine Headaches

Scott D. Sagel, MD

  • Longitudinal Study of Primary Ciliary Dyskinesia: Participants 5-18 Years of Age
  • A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study of VX-770 to Evaluate Safety, Pharmacokinetics, and Biomarkers of CFTR Activity in Cystic Fibrosis (CF) Subjects with Genotype G551D
  • Safety and Efficacy of a Novel Antioxidant-Rich Multivitamin Supplement for Persons with Cystic Fibrosis
  • Multicenter Trial to Validate Protein Biomarkers of a Pulmonary Exacerbation in Cystic Fibrosis

Teresa A. Sharp, PhD

  • Endothelial Function and its Relationship to Cardiovascular Disease Risk Factors in Lean and Overweight Pre- and Early-Pubertal Children

Ronald J. Sokol, MD

  • Randomized, Double-Blind, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants with Biliary Atresia
  • Biliary Atresia Study in Infants and Children (BASIC)
  • Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis

Marci Sontag, PhD

  • Gene Modifiers of Early CF Pulmonary Disease

Shikha S. Sundaram, MD, MSCI

  • Isoprostanes: A Marker of Oxidative Injury in Fatty Liver Disease

Joanne Valvano, PhD

  • Measurement of Voluntary Motor Control in the Affected Upper Extremity of the Child with Hemiplegic Cerebral Palsy

R. Paul Wadwa, MD

  • Determinants of Macrovascular Disease Risk in Adolescents with Type 1 Diabetes

Lisa Willis, MD

  • Assessment of Feeding Tolerance in Neonates with Ductal Dependent Cardiac Defects While Receiving Prostaglandin Therapy

Edith Zemanick, MD

  • Early Staphylococcal and Polymicrobial Bacterial Infection in CF