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Theresa Powell, PhD


Professor, Department of Pediatrics, Division of Neonatology

Education:
BS (1981) Morehead State University, PhD in Biology (1989) University of Kentucky. Postdoctoral fellowships at Department of Reproductive Sciences University of California San Diego (1989-1991) and Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco (1991-1994).
Contact:

Mail Stop 8613, RC2, Room 3100A
Phone: (303) 724 2016
Fax:   (303) 724 3512
Theresa.Powell@ucdenver.edu

Jansson-Powell Lab

Research interests:
Dr Powell is internationally recognized for her work in determining the molecular mechanisms regulating ion and macronutrient transport in the human placenta and characterizing changes in placental function in association to important pregnancy complications.  Currently, the primary focus of Dr. Powell’s research is to better understand how the abnormal metabolic environment of obesity or gestational diabetes in pregnant women affects placental function and the long-term health of her baby. Specifically, Dr. Powell is interested in identifying endocrine signals linking maternal adipose tissue to placental function and fetal growth and developing novel intervention paradigms for improving the maternal metabolic environment and pregnancy outcomes in obese women.


Recent Publications:

1: Ferchaud-Roucher V, Barner K, Jansson T, Powell TL. Maternal obesity results

in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with

anti-inflammatory and insulin-sensitizing properties. FASEB J. 2019

May;33(5):6643-6654. doi: 10.1096/fj.201802444R. Epub 2019 Feb 27. PubMed PMID:

30811959; PubMed Central PMCID: PMC6463919.

 

2: Ferchaud-Roucher V, Kramer A, Silva E, Pantham P, Weintraub ST, Jansson T,

Powell TL. A potential role for lysophosphatidylcholine in the delivery of long

chain polyunsaturated fatty acids to the fetal circulation. Biochim Biophys Acta

Mol Cell Biol Lipids. 2019 Mar;1864(3):394-402. doi:

10.1016/j.bbalip.2018.12.007. Epub 2018 Dec 18. PubMed PMID: 30572119.

 

3: Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC,

Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA. Placental lipoprotein

lipase activity is positively associated with newborn adiposity. Placenta. 2018

Apr;64:53-60. doi: 10.1016/j.placenta.2018.03.001. Epub 2018 Mar 5. PubMed PMID:

29626981.

 

4: Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in

placental long chain polyunsaturated fatty acid metabolism in human intrauterine

growth restriction. Clin Sci (Lond). 2018 Mar 15;132(5):595-607. doi:

10.1042/CS20171340. Print 2018 Mar 15. PubMed PMID: 29463583.

 

5: Castillo-Castrejon M, Powell TL. Placental Nutrient Transport in Gestational

Diabetic Pregnancies. Front Endocrinol (Lausanne). 2017 Nov 7;8:306. doi:

10.3389/fendo.2017.00306. eCollection 2017. Review. Erratum in: Front Endocrinol

(Lausanne). 2019 Jan 28;10:5. PubMed PMID: 29163373; PubMed Central PMCID:

PMC5682011.

 

6: Lager S, Ramirez VI, Acosta O, Meireles C, Miller E, Gaccioli F, Rosario FJ,

Gelfond JAL, Hakala K, Weintraub ST, Krummel DA, Powell TL. Docosahexaenoic Acid

Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient

Transport Capacity in Obese Women. J Clin Endocrinol Metab. 2017 Dec

1;102(12):4557-4567. doi: 10.1210/jc.2017-01384. PubMed PMID: 29053802; PubMed

Central PMCID: PMC5718695.

 

7: Díaz P, Dimasuay KG, Koele-Schmidt L, Jang B, Barbour LA, Jansson T, Powell

TL. Glyburide treatment in gestational diabetes is associated with increased

placental glucose transporter 1 expression and higher birth weight. Placenta.

2017 Sep;57:52-59. doi: 10.1016/j.placenta.2017.05.016. Epub 2017 May 31. PubMed

PMID: 28864019.

 

8: Ferchaud-Roucher V, Rudolph MC, Jansson T, Powell TL. Fatty acid and lipid

profiles in primary human trophoblast over 90h in culture. Prostaglandins Leukot

Essent Fatty Acids. 2017 Jun;121:14-20. doi: 10.1016/j.plefa.2017.06.001. Epub

2017 Jun 5. PubMed PMID: 28651693.

 

9: Howell KR, Powell TL. Effects of maternal obesity on placental function and

fetal development. Reproduction. 2017 Mar;153(3):R97-R108. doi:

10.1530/REP-16-0495. Epub 2016 Nov 18. Review. PubMed PMID: 27864335; PubMed

Central PMCID: PMC5432127.

 

10: Lager S, Ramirez VI, Gaccioli F, Jang B, Jansson T, Powell TL. Protein

expression of fatty acid transporter 2 is polarized to the trophoblast basal

plasma membrane and increased in placentas from overweight/obese women. Placenta.

2016 Apr;40:60-6. doi: 10.1016/j.placenta.2016.02.010. Epub 2016 Feb 21. PubMed

PMID: 27016784; PubMed Central PMCID: PMC4809740.

 

11: Cleaton MA, Dent CL, Howard M, Corish JA, Gutteridge I, Sovio U, Gaccioli F,

Takahashi N, Bauer SR, Charnock-Jones DS, Powell TL, Smith GC, Ferguson-Smith AC,

Charalambous M. Fetus-derived DLK1 is required for maternal metabolic adaptations

to pregnancy and is associated with fetal growth restriction. Nat Genet. 2016

Dec;48(12):1473-1480. doi: 10.1038/ng.3699. Epub 2016 Oct 24. PubMed PMID:

27776119; PubMed Central PMCID: PMC5373434.

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