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Lorna Moore, PhD


Professor, Division of Reproductive Sciences

Education:

PhD in Biomedical Anthropology (1973), University of Michigan, Ann Arbor, MI

Contact:

Mail Stop 8613, RC2, Room 3004
Phone: (303) 724 7474
Fax:   (303) 724 3512
Lorna.Moore@ucdenver.edu

Moore Lab

Research interests:
My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia.  I use the chronic hypoxia of residence at high altitude (>2500m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia.

Publications:
  1. Skeffington KL, Higgins JS, Sferruzzi-perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG.  Uterine artery (UtA) reactivity to AMP-activated protein kinase in control and hypoxic pregnancy.  J Physiol.  2015 Jun 25.  PMID: 26110512
  2. Bigham AW*, Julian CG*, Wilson MJ, Vargas E, Browne VA, Shriver MD, Moore LG.  Maternal genetic variation in EDNRA and PRKAA1 is associated with infant birth weight.  Physiol Genomics.  2014 Sep 15;46(18):687-97.  PMID: 25225183; PMCID: PMC4166715 (*These authors contributed equally to this work).
  3. Bigham AW, Mao X, Akey JM, Bauchet M, Brutsaert T, Mei R, Pinto D, Scherer S, Parra EJ, Julian CG Wilson MJ, Moore LG, Shriver MD.  Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.  Plos Genetics, Sept 2010; 6(9): 1-14.
  4. Julian CG, Wilson MJ, Lopez M, Yamashiro H, Tellez W, Rodriguez A, Bigham A, Shriver M, Rodriguez C, Vargas E, Moore LG.  Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth.  Am J Physiol.  May; 296(5): R1564-75, 2009.  PMID: 19244584; PMCID: PMC2689835.
  5. Julian CG, Galan HL, Wilson M, Desilva W, Cioffi-Ragan D, Schwartz J, Moore LG.  Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.  Am J Physiol Regul Integr Comp Physiol.  2008; Sep 295(3): R906-15.
  6. Mateev S, Sillau AH, Mouser R, McCullough RE, White MM, Young DY, Moore LG.  Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow.  AM J Physiol 2003; 284:H820-H829.
  7. Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young DY, Moore LG. Intrauterine growth restriction, preeclampsia and intrauterine mortality at high altitude in Bolivia. Pediatr Res. 2003; Jul 54(1): 20-25.
  8. Moore LG, Young D, McCullough RE, Droma T, Zamudio S.  Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude. Am J Hum Biol 2001; 13(5): 635-644.
  9. White MM, McCullough RE, Dyckes R, Robertson AD, Moore LG.  Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries. Am J Physiol 2000; 278(6): H2069-H2075. 
  10. Jensen GM, Moore LG.  The effect of high altitude and other risk factors on birth weight: independent or interactive? Am J Public Health 1997; 87(6): 1003-1007.
  11. Niermeyer S, Yang P, Shanmina, Drolkar, Zhuang J, Moore LG. Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet.  N Engl J Med 1995; 333(19): 1248-1252.
  12. Palmer SK, Zamudio S, Coffin C, Parker S, Stamm E, Moore LG. Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy. Obstet Gynecol 1992; 80(6): 1000-1006.