Assistant Professor, Division of Reproductive Sciences
Secondary Appointment, Division of Reproductive Endocrinology and Infertility
PhD in Biology (2002), Arizona State University, Tempe, AZ.
Postdoctoral Fellowship, Vincent Center for Reproductive Biology, Harvard Medical School, Boston, MA.
Mail Stop 8613, RC2, Room 3450D
Dr. Johnson's research program focuses on the control of oocyte number inside the ovary, primarily in mammals, but also in the fruit fly model organism. We are currently focused on mechanisms that support oocyte quality--the ability to give rise to a healthy offspring--and those that lead to oocyte loss, due to 'normal' aging and in the context of human premature ovarian failure (POF). To maximize his clinical/ translation acumen, Dr. Johnson was trained and worked part-time as an embryologist in the Yale IVF Center. Now, our primary mission is to better understand the function of the ovary so we can first identify women whose ovaries are at risk of failing or who will have trouble conceiving, and one day intervene to protect fertility and organ function.
Kurus, M., Karakaya, C., Karalok, M.H., To, G., Johnson, J. (2013) The Control of Oocyte Survival by Intrinsic and Extrinsic Factors, in “Oocyte Biology in Fertility Preservation,” S. Kim, ed. Springer Science. Advances in Experimental Medicine and Biology, 761:7-18.
Thomson, T.C., Johnson, J. (2010) Inducible Somatic Oocyte Destruction in response to Rapamycin requires wild-type regulation of follicle cell epithelial polarity. Cell Death and Diﬀerentiation. 17, 1717- 27
Yaba, A., Bianchi, V., Borini, A., Johnson, J. (2008) A putative mitotic checkpoint dependent on mTOR function controls cell proliferation and survival in ovarian granulosa cells, Reproductive Sciences. 15,128-38.
Johnson, J., Bagley, J., Skaznik-Wikiel, M., Lee, H.-J., Adams, G.B., Niikura, Y., Tschudy, K.S., Canning Tilly, J., Cortes, M. L., Forkert, R., Spitzer, T., Iacomini, J., Scadden, D.T., Tilly, J.L. (2005) Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood. Cell. 122, 303-315.
Johnson, J., Canning, J., Kaneko, T., Pru, J.K., Tilly, J.L. (2004) Germline stem cells and follicular repopulation in the postnatal mammalian ovary. Nature. 428, 145-150.