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Thomas Jansson, MD, PhD


Florence Crozier Cobb Endowed Professor, Chief Division of Reproductive Sciences
Vice Chair of Research at the Department of Obstetrics & Gynecology

Education:

MD, Gothenburg University, Sweden (1985); PhD in Physiology, Gothenburg University, Sweden (1990)

Contact:
Mail Stop 8613, RC2, Room 3100C
Phone: (303) 724 8622
Fax:   (303) 724 3512
Thomas.Jansson@ucdenver.edu


Research Interests:
Dr. Jansson has national and international recognition for his translational research exploring the cellular and molecular mechanisms of regulation of placental nutrient transporters and investigating the role of placental function in determining fetal growth and long-term health. Dr. Jansson has a distinguished publication record, serves regularly on NIH and international study sections and is the Principal Investigator on numerous NIH grants.


Recent Publications:
 

1. Rosario F, Kanai, Y, Powell TL, Jansson T. 2015. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity, 23(8):1663-70. 

2. Chen YY, Rosario F, Powell TL, Han VKM, Gupta MB, Jansson T. 2015. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human. Clin Science, 129(12):1131-41. 

3. Aye ILMH, Rosario F, Powell TL, Jansson T 2015. Adiponectin Supplementation in Pregnant Mice Prevents the Adverse Effects of Maternal Obesity on Placental Function and Fetal Growth. Proc Natl Acad Sci, 112:12858-63. 

4. Hu M, Richard, J, Maliqueo M, Kokosar, M, Fornes, R, Benrick, A, Jansson T, Ohlson C, Wu, X, Skibicka, K, Stener-Victorin E. 2015. Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring. Proc Natl Acad Sci112:14348-53. 

5. Rosario F, Powell TL, Jansson T. 2016. Regulation of Trophoblast Amino Acid Transporter Trafficking by mTOR Complex 1 is Mediated by the Ubiquitin Ligase Nedd4-2. Clin Science, 130(7):499-512. 

6. Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. 2016 Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 130:499-512. 

7. Rosario FJ, Powell TL and Jansson T 2016 Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC. Sci Rep. 6:31705. 

8. Rosario FJ, Powell TL and Jansson T 2017 mTOR folate sensing links folate availability to trophoblast cell function. J Physiol, 595(13):4189-4206

9. Dimasuay KG, Aitken EH, Rosario FJ, Njie M, Glazier JD, Rogerson, SJ, Fowkes FJI, Beeson JG, Powell TL, Jansson, T*, Boeuf P* 2017 Inhibition of placental mTOR signaling provides a link between placental malaria and low birthweight. BMC Medicine: 15(1):1​ (*Co-senior author)