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Moore Lab


​High altitude (>2500 m or 8000 ft) exerts one of the most powerful effects on fetal growth, making it a natural laboratory for understanding maternal physiologic responses contributing to fetal growth restriction. Our past work showed that multigenerational populations (Andeans, Tibetans) are relatively protected from hypoxia-associated fetal growth restriction compared with shorter–term groups (Europeans, Han “Chinese”) due primarily to genetic factors enabling a normal pregnancy rise in uterine artery blood flow. Current studies are aimed at determining the physiological pathways involved and, in particular, the roles of AMPKα activation and epigenetic changes due to DNA methylation. (top left to right, clockwise) Alexandrea Doyle, HeaMi Yi, Dr. Ramon Lorca, Elise Bales, Dr. Lorna Moore, Sydney Coates and Hisham Nsier)




 


 




Lorna Moore, PhD, Professor of Obstetrics and Gynecology

     Office: Research Complex II, Room 3004

     Phone: 303-724-7474

 

Sydney Coates, PhD student, Integrated Physiology

     Office: Research Complex II, Room 3410D

     Phone: 303-724-1125

 

Colleen G. Julian, PhD, Assistant Professor of Medicine

     Office: Research Complex II, Room 3123

     Phone: 303-724-6446

 

Ramón Lorca, PhD, Instructor of Obstetrics and Gynecology

     Office: Research Complex II, Room 3100D

     Phone: 303-724-1126


Elise Bales, BS, Professional Research Assistant

     Office: Research Complex II, Room 3410D

     Phone: 303-724-3504


  1. Julian CG, Galan HL, Wilson M, Desilva W, Cioffi-Ragan D, Schwartz J, Moore LG. Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. Am J Physiol 2008 Sep; 295(3): R906-15. PMCID: PMC2536855.
  2. Julian CG, Wilson MJ, Lopez M, Yamashiro H, Tellez W, Rodriguez A, Bigham A, Shriver M, Rodriguez C, Vargas E, Moore LG. Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth. Am J Physiol. May; 296(5): R1564-75, 2009. PMID: 19244584; PMCID: PMC2689835
  3. Bigham AW, Mao X, Akey JM, Bauchet M, Brutsaert T, Mei R, Pinto D, Scherer S, Parra EJ, Julian CG, Wilson MJ, Moore LG, Shriver MD. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. Plos Genetics, Sept 2010; 6(9): 1-14. PMID: 20838600; PMCID: PMC2936536.
  4. Bigham AW*, Julian CG*, Wilson MJ, Vargas E, Browne VA, Shriver MD, Moore LG. Maternal genetic variation in EDNRA and PRKAA1 is associated with infant birth weight. Physiol Genomics. 2014 Sep 15;46(18):687-97. PMID: 25225183; PMCID: PMC4166715 (* These authors contributed equally to this work).
  5. Skeffington KL, Higgins JS, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG. Uterine artery (UtA) reactivity to AMP-activated protein kinase in control and hypoxic pregnancy. J Physiol. 2015 Jun 25. [Epub ahead of print] pubmed/26110512
  6. Julian CG, Gonzalez M, Rodriguez A, Bellido D, Salinas C, Ladenburger A, Reardon L, Van-Houten SJ, Vargas E, Moore LG.  Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H565-73. PMCID: PMC4537943
  7. Moore LG. Human genetic adaptation to high altitude: current status and future prospects. Quaternary International (2016), http://dx.doi.org/10.1016/j.quaint.2016.09.045
  8. Tashi T, Reading NS, Shestakova A, Burjanivova T, Uran T, Lorenzo F, Hu H, Huff C, Moore L, Koul P,Wittwer C, Gordeuk VR, Ge RL,  Prchal JT.  Tibetan gain-of-function variant of prolyl hydroxylase 2 (EGLN1) and selected SNPs of HIF-2-alpha (EPAS1) are associated with lower hemoglobin values in Tibetans. Blood 2015 126:3332.
  9. Wolfson G, Browne VA, Vargas E, Moore LG, Julian CG. Erythropoietin and soluble erythropoietin receptor: a role for maternal vascular adaptation to high altitude pregnancy. J Clin Endo Metabolism (in press).​
NICHD, RO1 HD0088590, LG Moore PI and CG Julian Co-I, Chronic hypoxia, AMPK activation and uterine artery blood flow​

Center for Women’s Health Research Junior Faculty Development Award to AG Euser
, The effect of high-altitude residence on myometrial vasoreactivity in term pregnancy

American Heart Association, Beginning Grant-In-Aid to CG Julian, Epigenomic regulation of hypoxia-induced vascular disorders of pregnancy

NIH Building Interdisciplinary Research Careers in Womenʼs Health (BIRCWH) to CG Julian, Hypoxia-associated impairment of fetal growth: epigenomic perspectives

2009-15:  Listings #2, 4, and 7 in the publications tab were featured publications for the American Physiological Society's APSselect program

2010:  LG Moore, recipient of the Franz Boas Distinguished Achievement Award from the Human Biology Association

2013:  LG Moore, recipient of the Grover Prize from the American Thoracic Society

2015:  AG Euser, recipient of Society for Reproductive Investigation President's Presenter Award

Other: LG Moore, co-founder of the Center for Women's Health Research, Univ. Colorado School of Medicine

            LG Moore, Dean of the Graduate School of Arts & Sciences, Wake Forest University (2007-2012)

                            President, North Carolina Council of Graduate Schools (2012)